This paper was published in 2024 and has 47 citations in Litlas.
Detection of the TFAM-mtDNA complex from damaged intestinal epithelium by myeloid STING exacerbates colitis through IL-12 cytokines, providing new evidence to support the development of STING as a therapeutic target for UC and CAC.
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Interleukin 12 is expressed and actively… Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells Constitutive p40 promoter activation and… Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells Anti–Interleukin-12 Antibody for Active… Anti–Interleukin-12 Antibody for Active Crohn's Disease A Genome-Wide Association Study… A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene Interleukin-23 drives innate and T… Interleukin-23 drives innate and T cell–mediated intestinal inflammation Crohn’s disease: Th1, Th17 or both? The chang… Crohn’s disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn’s disease Innate and adaptive immunity in inflammator… Innate and adaptive immunity in inflammatory bowel disease STING-Dependent Signaling Underlies… STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis Stimulator of interferon genes (STING) activatio… Stimulator of interferon genes (STING) activation exacerbates experimental colitis in mice Extracellular vesicles package dsDNA to… Extracellular vesicles package dsDNA to aggravate Crohn’s disease by activating the STING pathway Dysbiosis exacerbates colitis by promoting… Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells Intrinsic STING Switches off Pathogenetic… Intrinsic STING Switches off Pathogenetic Programs of Th1 Cells to Inhibit Colitis Potential therapeutic strategies for colitis… Potential therapeutic strategies for colitis and colon cancer: bidirectional targeting STING pathway Mitochondrial DNA-activated cGAS-STIN… Mitochondrial DNA-activated cGAS-STING pathway in cancer: Mechanisms and therapeutic implications Inflammatory Bowel Disease (IBD)-Associate… Inflammatory Bowel Disease (IBD)-Associated Colorectal Cancer (CRC): Is cGAS-STING Pathway Targeting the Key to Chemoprevention? cGAS-STING pathway as a promising target for… cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products The role of cGAS-STING signaling in the liver… The role of cGAS-STING signaling in the liver and gastrointestinal system: from signaling networks to target intervention cGAS–STING signaling pathway as a therapeuti… cGAS–STING signaling pathway as a therapeutic target in human diseases Role of cGAS-STING pathway in fibrotic… Role of cGAS-STING pathway in fibrotic disease Disturbance of cytoskeleton induced by… Disturbance of cytoskeleton induced by ligustilide promotes hepatic stellate cell senescence and ameliorates liver fibrosis Manganese dioxide-based in situ vaccine boosts… Manganese dioxide-based in situ vaccine boosts antitumor immunity via simultaneous activation of immunogenic cell death and the STING pathway Organoids for tissue repair and regeneration Organoids for tissue repair and regeneration Inflammatory Bowel Disease Induces… Inflammatory Bowel Disease Induces Colorectal Cancer: Risk Factors, Triggering Mechanisms, and Treatment With Phyto‐Derivatives Cell-free mitochondrial DNA as a… Cell-free mitochondrial DNA as a pro-inflammatory agent in blood circulation: mechanisms, therapeutic implications, and clinical challenges in immune dysregulation Intestinal epithelial damage-derived mtDNA… Intestinal epithelial damage-derived mtDNA activates STING-IL12 axis in dendritic cells to promote colitis Earlier references Focus paper Citing papers Older Newer Click a node to pin it, click the empty canvas to go back to this paper, or hover to preview. Open a node’s page from its title.
