litlas
Log inCreate account

Akin Akinc

Active 2002–2024

41
Papers
23,887
Citations
39
h-index
40
i10-index

Citations

Citations per year for Akin Akinc1989: 1 citations1994: 4 citations2002: 2 citations2003: 3 citations2004: 17 citations2005: 68 citations2006: 132 citations2007: 173 citations2008: 188 citations2009: 220 citations2010: 219 citations2011: 268 citations2012: 337 citations2013: 267 citations2014: 310 citations2015: 342 citations2016: 353 citations2017: 293 citations2018: 391 citations2019: 879 citations2020: 1,038 citations2021: 1,190 citations2022: 1,121 citations2023: 1,095 citations2024: 1,475 citations2025: 908 citations2026: 28 citations1990–1993: no citations, so these years are not shown1995–2001: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 2,803 citing papers, 28.9% of this breakdownChina: 1,405 citing papers, 14.5% of this breakdownGermany: 506 citing papers, 5.2% of this breakdownUnited Kingdom: 441 citing papers, 4.6% of this breakdownCanada: 425 citing papers, 4.4% of this breakdownJapan: 326 citing papers, 3.4% of this breakdownFrance: 244 citing papers, 2.5% of this breakdownAustralia: 240 citing papers, 2.5% of this breakdownSouth Korea: 237 citing papers, 2.4% of this breakdownItaly: 235 citing papers, 2.4% of this breakdownNetherlands: 232 citing papers, 2.4% of this breakdownIndia: 227 citing papers, 2.3% of this breakdown
0%28.9%Other 24.5%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology69%
  • Medicine15.7%
  • Materials Science6.2%
  • Immunology and Microbiology3.8%
  • Engineering2.2%
  • Pharmacology, Toxicology and Pharmaceutics0.8%
  • Other2.3%

Topics

  • RNA Interference and Gene Delivery20.5%
  • Advanced biosensing and bioanalysis techniques12.2%
  • MicroRNA in disease regulation4.8%
  • Nanoparticle-Based Drug Delivery4.1%
  • Virus-based gene therapy research3.7%
  • Immunotherapy and Immune Responses2.7%
  • Other52%

Coauthors

All papers

Open in search
  1. The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

    Authors: Akin Akinc, Martin A. Maier, Muthiah Manoharan, Kevin Fitzgerald, Muthusamy Jayaraman, Scott Barros, Steven M. Ansell, Xinyao Du, Michael J. Hope, Thomas D. Madden, Barbara L. Mui, Sean C. Semple, Ying K. Tam, Marco A. Ciufolini, Dominik Witzigmann, Jayesh A. Kulkarni, Roy van der Meel, Pieter R. Cullis - Nature Nanotechnology 2019 cited by 1,569

  2. Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

    Authors: Jérôme Gilleron, William Querbes, Anja Zeigerer, Anna Borodovsky, Giovanni Marsico, Undine Schubert, K. Manygoats, Sarah Seifert, Cordula Andree, Martin Stöter, Hila Epstein-Barash, Ligang Zhang, Victor Koteliansky, Kevin Fitzgerald, Eugenio Fava, Marc Bickle, Yannis Kalaidzidis, Akin Akinc, Martin A. Maier, Marino Zerial - Nature Biotechnology 2013 cited by 1,576

  3. Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

    Authors: Muthusamy Jayaraman, Steven M. Ansell, Barbara L. Mui, Ying K. Tam, Jianxin Chen, Xinyao Du, David Butler, Laxman Eltepu, Shigeo Matsuda, Jayaprakash K. Narayanannair, Kallanthottathil G. Rajeev, Ismail M. Hafez, Akin Akinc, Martin A. Maier, Mark A. Tracy, Pieter R. Cullis, Thomas D. Madden, Muthiah Manoharan, Michael J. Hope - Angewandte Chemie 2012 cited by 1,221

  4. Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

    Authors: Akin Akinc, William Querbes, Soma De, June Qin, Maria Frank-Kamenetsky, K. N. Jayaprakash, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, William Cantley, J. Robert Dorkin, James S. Butler, LiuLiang Qin, Timothy Racie, Andrew Sprague, Eugenio Fava, Anja Zeigerer, Michael J. Hope, Marino Zerial, Dinah W.Y. Sah, Kevin Fitzgerald, Mark A. Tracy, Muthiah Manoharan, Victor Koteliansky, Antonin de Fougerolles, Martin A. Maier - Molecular Therapy 2010 cited by 1,215

  5. Rational design of cationic lipids for siRNA delivery

    Authors: Sean C. Semple, Akin Akinc, Jianxin Chen, Ammen P. Sandhu, Barbara L. Mui, Connie K Cho, Dinah W.Y. Sah, Derrick Stebbing, Erin Crosley, Ed Yaworski, Ismail M. Hafez, J. Robert Dorkin, June Qin, Kieu Lam, Kallanthottathil G. Rajeev, Kim F. Wong, Lloyd B. Jeffs, Lubomir V. Nechev, Merete L. Eisenhardt, Muthusamy Jayaraman, Mikameh Kazem, Martin A. Maier, Masuna Srinivasulu, Michael J Weinstein, Qingmin Chen, Rene Alvarez, Scott Barros, Soma De, Sandra K. Klimuk, Todd Borland, Verbena Kosovrasti, William Cantley, Ying K. Tam, Muthiah Manoharan, Marco A. Ciufolini, Mark A. Tracy, Antonin de Fougerolles, Ian MacLachlan, Pieter R. Cullis, Thomas D. Madden, Michael J. Hope - Nature Biotechnology 2010 cited by 1,779

  6. Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

    Authors: Martin A. Maier, Muthusamy Jayaraman, Shigeo Matsuda, Ju Liu, Scott Barros, William Querbes, Ying K. Tam, Steven M. Ansell, Varun Kumar, June Qin, Xuemei Zhang, Qianfan Wang, Sue Panesar, Renta Hutabarat, Mary Carioto, Julia Hettinger, Kandasamy Pachamuthu, David Butler, Kallanthottathil G. Rajeev, Bo Pang, Klaus Charissé, Kevin Fitzgerald, Barbara L. Mui, Xinyao Du, Pieter R. Cullis, Thomas D. Madden, Michael J. Hope, Muthiah Manoharan, Akin Akinc - Molecular Therapy 2013 cited by 619

  7. Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

    Authors: Barbara L. Mui, Ying K. Tam, Muthusamy Jayaraman, Steven M. Ansell, Xinyao Du, Yuen Yi C. Tam, Paulo J.C. Lin, Sam Chen, Jayaprakash K. Narayanannair, Kallanthottathil G. Rajeev, Muthiah Manoharan, Akin Akinc, Martin A. Maier, Pieter R. Cullis, Thomas D. Madden, Michael J. Hope - Molecular Therapy — Nucleic Acids 2013 cited by 482

  8. Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

    Authors: Jayaprakash K. Nair, Jennifer L. S. Willoughby, Amy Chan, Klaus Charissé, Md. Rowshon Alam, Qianfan Wang, Menno Hoekstra, Kandasamy Pachamuthu, Alexander V. Kel’in, Stuart Milstein, Nate Taneja, Jonathan O′Shea, Sarfraz Shaikh, Ligang Zhang, Ronald J. van der Sluis, Michael E. Jung, Akin Akinc, Renta Hutabarat, Satya Kuchimanchi, Kevin Fitzgerald, Tracy Zimmermann, Theo J.C. van Berkel, Martin A. Maier, Kallanthottathil G. Rajeev, Muthiah Manoharan - Journal of the American Chemical Society 2014 cited by 1,078

  9. Lipid-like materials for low-dose, in vivo gene silencing

    Authors: Kevin T. Love, Kerry P. Mahon, Christopher G. Levins, Kathryn A. Whitehead, William Querbes, J. Robert Dorkin, June Qin, William Cantley, Liu Liang Qin, Timothy Racie, Maria Frank-Kamenetsky, Ka Ning Yip, Rene Alvarez, Dinah W.Y. Sah, Antonin de Fougerolles, Kevin Fitzgerald, Victor Koteliansky, Akin Akinc, Róbert Langer, Daniel G. Anderson - National Academy of Sciences, Proceedings of the National Academy of Sciences 2010 cited by 965

  10. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

    Authors: Akin Akinc, Andreas Zumbuehl, Michael S. Goldberg, Elizaveta S. Leshchiner, Valentina Busini, Naushad Hossain, Sergio Bacallado, David N. Nguyen, Jason Fuller, Rene Alvarez, Anna Borodovsky, Todd Borland, Rainer Constien, Antonin de Fougerolles, J. Robert Dorkin, K. N. Jayaprakash, Muthusamy Jayaraman, Matthias John, Victor Koteliansky, Muthiah Manoharan, Lubomir V. Nechev, June Qin, Timothy Racie, Denitza Raitcheva, Kallanthottathil G. Rajeev, Dinah W.Y. Sah, Jürgen Soutschek, Ivanka Toudjarska, Hans‐Peter Vornlocher, Tracy Zimmermann, Róbert Langer, Daniel G. Anderson - Nature Biotechnology 2008 cited by 1,220

  11. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

    Authors: Yizhou Dong, Kevin T. Love, J. Robert Dorkin, Sasilada Sirirungruang, Yunlong Zhang, Delai Chen, Roman L. Bogorad, Hao Yin, Yi Chen, Arturo J. Vegas, Christopher A. Alabi, Gaurav Sahay, Karsten Olejnik, Weiheng Wang, Avi Schroeder, Abigail K. R. Lytton‐Jean, Daniel J. Siegwart, Akin Akinc, Carmen Barnes, Scott Barros, Mary Carioto, Kevin Fitzgerald, Julia Hettinger, Varun Kumar, Tatiana I. Novobrantseva, June Qin, William Querbes, Victor Koteliansky, Róbert Langer, Daniel G. Anderson - National Academy of Sciences, Proceedings of the National Academy of Sciences 2014 cited by 481

  12. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight

    Authors: James E. Dahlman, Carmen Barnes, Omar F. Khan, Aude Thiriot, Siddharth Jhunjunwala, Taylor E. Shaw, Yiping Xing, Hendrik B. Sager, Gaurav Sahay, Lauren Speciner, Andrew Bader, Roman L. Bogorad, Hao Yin, Tim Racie, Yizhou Dong, Shan Jiang, Danielle Seedorf, Apeksha Dave, Kamaljeet Singh Sandhu, Matthew J. Webber, Tatiana I. Novobrantseva, Vera M. Ruda, Abigail K. R. Lytton‐Jean, Christopher G. Levins, Brian T. Kalish, Dayna K. Mudge, Mario Pérez, Ludmila Abezgauz, Partha Dutta, Lynelle P. Smith, Klaus Charissé, Mark W. Kieran, Kevin Fitzgerald, Matthias Nahrendorf, Dganit Danino, Rubin M. Tuder, Ulrich H. von Andrian, Akin Akinc, Dipak Panigrahy, Avi Schroeder, Victor Koteliansky, Róbert Langer, Daniel G. Anderson - Nature Nanotechnology 2014 cited by 573

  13. Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates

    Authors: Jayaprakash K. Nair, Husain Attarwala, Alfica Sehgal, Qianfan Wang, Krishna Aluri, Xuemei Zhang, Minggeng Gao, Ju Liu, Ramesh Indrakanti, Sally Schofield, Philip Kretschmer, Christopher R. Brown, Swati Gupta, Jennifer L. S. Willoughby, Julie A. Boshar, Vasant Jadhav, Klaus Charissé, Tracy Zimmermann, Kevin Fitzgerald, Muthiah Manoharan, Kallanthottathil G. Rajeev, Akin Akinc, Renta Hutabarat, Martin A. Maier - Nucleic Acids Research 2017 cited by 270

  14. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

    Authors: Jürgen Soutschek, Akin Akinc, Birgit Bramlage, Klaus Charissé, Rainer Constien, Mary Donoghue, Sayda M. Elbashir, Anke Geick, Philipp Hadwiger, Jens Harborth, Matthias John, Venkitasamy Kesavan, Gary Lavine, Rajendra K. Pandey, Timothy Racie, Kallanthottathil G. Rajeev, Ingo Röhl, Ivanka Toudjarska, Gang Wang, Silvio Wuschko, David Bumcrot, Victor Koteliansky, Stefan Limmer, Muthiah Manoharan, Hans‐Peter Vornlocher - Nature 2004 cited by 2,187

  15. MicroRNAs 103 and 107 regulate insulin sensitivity

    Authors: Mirko Trajkovski, Jean Hausser, Jürgen Soutschek, Bal Bhat, Akin Akinc, Mihaela Zavolan, Markus H. Heim, Markus Stoffel - Nature 2011 cited by 993

  16. Shielding of Lipid Nanoparticles for siRNA Delivery: Impact on Physicochemical Properties, Cytokine Induction, and Efficacy

    Authors: Varun Kumar, June Qin, Yongfeng Jiang, Richard G. Duncan, Benjamin Brigham, Shannon Fishman, Jayaprakash K. Nair, Akin Akinc, Scott Barros, Pia V. Kasperkovitz - Molecular Therapy — Nucleic Acids 2014 cited by 217

  17. Exploring polyethylenimine‐mediated DNA transfection and the proton sponge hypothesis

    Authors: Akin Akinc, Mini Thomas, Alexander M. Klibanov, Róbert Langer - The Journal of Gene Medicine 2004 cited by 1,329

  18. RNAi-mediated gene silencing in non-human primates

    Authors: Tracy Zimmermann, Amy C. H. Lee, Akin Akinc, Birgit Bramlage, David Bumcrot, Matthew Fedoruk, Jens Harborth, James Heyes, Lloyd B. Jeffs, Matthias John, Adam D. Judge, Kieu Lam, Kevin McClintock, Lubomir V. Nechev, Lorne Palmer, Timothy Racie, Ingo Röhl, Stephan Seiffert, Sumi Shanmugam, Vandana Sood, Jürgen Soutschek, Ivanka Toudjarska, Amanda J. Wheat, Ed Yaworski, William Zedalis, Victor Koteliansky, Muthiah Manoharan, Hans‐Peter Vornlocher, Ian MacLachlan - Nature 2006 cited by 1,350

  19. Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver

    Authors: Akin Akinc, Michael S. Goldberg, June Qin, J. Robert Dorkin, Christina Gamba‐Vitalo, Martin A. Maier, K. N. Jayaprakash, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, Muthiah Manoharan, Victor Koteliansky, Ingo Röhl, Elizaveta S. Leshchiner, Róbert Langer, Daniel G. Anderson - Molecular Therapy 2009 cited by 349

  20. An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia

    Authors: Alfica Sehgal, Scott Barros, Lacramioara Ivanciu, Brian C. Cooley, June Qin, Tim Racie, Julia Hettinger, Mary Carioto, Yongfeng Jiang, Josh Brodsky, Harsha Prabhala, Xuemei Zhang, Husain Attarwala, Renta Hutabarat, Don Foster, Stuart Milstein, Klaus Charissé, Satya Kuchimanchi, Martin A. Maier, Lubo Nechev, Kandasamy Pachamuthu, Alexander V. Kel’in, Jayaprakash K. Nair, Kallanthottathil G. Rajeev, Muthiah Manoharan, Rachel Meyers, Benny Sørensen, Amy Simon, Yesim Dargaud, Claude Négrier, Rodney M. Camire, Akin Akinc - Nature Medicine 2015 cited by 297

  21. Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy

    Authors: John Pasi, Savita Rangarajan, Pencho Georgiev, Tim Mant, Michael Desmond Creagh, Toshko Lissitchkov, David Bevan, Steve Austin, C. R. M. Hay, Inga Hegemann, Rashid Kazmi, Pratima Chowdary, Liana Gercheva, Vasily Mamonov, Margarita Timofeeva, Chang-Heok Soh, Pushkal Garg, Akshay Vaishnaw, Akin Akinc, Benny Sørensen, Margaret V. Ragni - New England Journal of Medicine 2017 cited by 357

  22. 5′‐(E)‐Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA–GalNAc Conjugates

    Authors: Rubina Parmar, Jennifer L. S. Willoughby, Jingxuan Liu, Donald J. Foster, Benjamin Brigham, Christopher S. Theile, Klaus Charissé, Akin Akinc, Erin N. Guidry, Yi Pei, Walter Strapps, Mark T. Cancilla, Matthew G. Stanton, Kallanthottathil G. Rajeev, Laura Sepp‐Lorenzino, Muthiah Manoharan, Rachel Meyers, Martin A. Maier, Vasant Jadhav - ChemBioChem 2016 cited by 137

  23. Reversal of siRNA-mediated gene silencing in vivo

    Authors: Ivan Zlatev, Adam Castoreno, Christopher R. Brown, June Qin, Scott Waldron, Mark K. Schlegel, Rohan Degaonkar, Svetlana Shulga‐Morskaya, Huilei Xu, Swati Gupta, Shigeo Matsuda, Akin Akinc, Kallanthottathil G. Rajeev, Muthiah Manoharan, Martin A. Maier, Vasant Jadhav - Nature Biotechnology 2018 cited by 92

  24. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

    Authors: Maria Frank-Kamenetsky, Aldo Grefhorst, Norma N. Anderson, Timothy Racie, Birgit Bramlage, Akin Akinc, David Butler, Klaus Charissé, Robert Dorkin, Yupeng Fan, Christina Gamba‐Vitalo, Philipp Hadwiger, Muthusamy Jayaraman, Matthias John, K. N. Jayaprakash, Martin A. Maier, Lubomir V. Nechev, Kallanthottathil G. Rajeev, Timothy Read, Ingo Röhl, Jürgen Soutschek, Pamela Tan, Jamie Wong, Gang Wang, Tracy Zimmermann, Antonin de Fougerolles, Hans-Peter Vornlocher, Róbert Langer, Daniel G. Anderson, Muthiah Manoharan, Victor Koteliansky, Jay D. Horton, Kevin Fitzgerald - National Academy of Sciences, Proceedings of the National Academy of Sciences 2008 cited by 639