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Channing J. Der

Active 1982–2025

240
Papers
56,713
Citations
127
h-index
234
i10-index

Citations

Citations per year for Channing J. Der1951: 2 citations1979: 1 citations1982: 13 citations1983: 53 citations1984: 60 citations1985: 45 citations1986: 53 citations1987: 45 citations1988: 35 citations1989: 47 citations1990: 111 citations1991: 144 citations1992: 155 citations1993: 141 citations1994: 231 citations1995: 270 citations1996: 263 citations1997: 476 citations1998: 485 citations1999: 672 citations2000: 770 citations2001: 656 citations2002: 658 citations2003: 642 citations2004: 602 citations2005: 584 citations2006: 508 citations2007: 584 citations2008: 471 citations2009: 431 citations2010: 440 citations2011: 448 citations2012: 385 citations2013: 360 citations2014: 405 citations2015: 385 citations2016: 410 citations2017: 408 citations2018: 359 citations2019: 1,221 citations2020: 1,464 citations2021: 1,435 citations2022: 1,135 citations2023: 662 citations2024: 1,132 citations2025: 669 citations2026: 30 citations1952–1978: no citations, so these years are not shown1980–1981: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 7,874 citing papers, 40.1% of this breakdownChina: 1,764 citing papers, 9% of this breakdownUnited Kingdom: 1,134 citing papers, 5.8% of this breakdownGermany: 1,086 citing papers, 5.5% of this breakdownJapan: 847 citing papers, 4.3% of this breakdownCanada: 661 citing papers, 3.4% of this breakdownFrance: 609 citing papers, 3.1% of this breakdownItaly: 589 citing papers, 3% of this breakdownSpain: 423 citing papers, 2.2% of this breakdownNetherlands: 382 citing papers, 1.9% of this breakdownAustralia: 356 citing papers, 1.8% of this breakdownSouth Korea: 336 citing papers, 1.7% of this breakdown
0%40.1%Other 18.2%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology59.3%
  • Medicine29.5%
  • Immunology and Microbiology4.4%
  • Neuroscience2.5%
  • Computer Science0.9%
  • Chemistry0.7%
  • Other2.7%

Topics

  • Protein Kinase Regulation and GTPase Signaling6.7%
  • Melanoma and MAPK Pathways2.8%
  • PI3K/AKT/mTOR signaling in cancer2.5%
  • Cellular Mechanics and Interactions2.4%
  • Cellular transport and secretion2.2%
  • Cancer-related Molecular Pathways2.2%
  • Other81.2%

Coauthors

All papers

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  1. Drugging the undruggable RAS: Mission Possible?

    Authors: Adrienne D. Cox, Stephen W. Fesik, Alec C. Kimmelman, Ji Luo, Channing J. Der - Nature Reviews Drug Discovery 2014 cited by 2,003

  2. Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

    Authors: Matthew Holderfield, Bianca J. Lee, Jingjing Jiang, Aidan C.A. Tomlinson, Kyle J. Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart, Julien Dilly, Yevgeniy Gindin, Nuntana Dinglasan, Yingyun Wang, Lo Lai, Shurui Cai, Lingyan Jiang, Nicole Nasholm, Nataliya Tovbis Shifrin, Cristina Blaj, Harshit Shah, James Evans, Nilufar Montazer, Oliver Lai, Jade Shi, Ethan Ahler, Elsa Quintana, Stephanie Chang, Anthony Salvador, Abby Marquez, Jim Cregg, Yang Liu, Anthony N. Milin, Anqi Chen, Tamar Bar Ziv, Dylan Parsons, John E. Knox, Jennifer E. Klomp, Jennifer A. Roth, Matthew G. Rees, Melissa M. Ronan, Antonio Cuevas-Navarro, Feng Hu, Piro Lito, David Santamarı́a, Andrew J. Aguirre, Andrew M. Waters, Channing J. Der, Chiara Ambrogio, Zhengping Wang, Adrian L. Gill, Elena S. Koltun, Jacqueline A.M. Smith, David Wildes, Mallika Singh - Nature 2024 cited by 318

  3. KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer

    Authors: Andrew M. Waters, Channing J. Der - Cold Spring Harbor Perspectives in Medicine 2017 cited by 866

  4. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

    Authors: Patrick J. Roberts, Channing J. Der - Oncogene 2007 cited by 2,796

  5. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

    Authors: Yingxue Wang, Daniel Zeitouni, Clint A. Stalnecker, Haoqiang Ying, Erik S. Knudsen, Guofang Zhang, Pankaj K. Singh, Agnieszka K. Witkiewicz, Venugopal Gunda, Andrey P. Tikunov, Adrienne D. Cox, Garima Tomar, Sen Peng, Jennifer E. Klomp, Andrew M. Waters, Mariaelena Pierobon, J. Nathaniel Diehl, Tikvah K. Hayes, Yan Liang, G. Aaron Hobbs, Emanuel F. Petricoin, Channing J. Der, Jeffrey M. Macdonald, Costas A. Lyssiotis, Alec C. Kimmelman, Gennifer D. Goode, Samuel D. George, Nhan L. Tran, Kirsten L. Bryant, Bjoern Papke, Nina V. Chaika - Nature Medicine 2019 cited by 715

  6. RAS isoforms and mutations in cancer at a glance

    Authors: G. Aaron Hobbs, Channing J. Der, Kent L. Rossman - Journal of Cell Science 2016 cited by 991

  7. Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer

    Authors: Urszula N. Wasko, Jingjing Jiang, Tanner C. Dalton, Álvaro Curiel‐García, A. Cole Edwards, Yingyun Wang, Bianca J. Lee, Margo Orlen, Sha Tian, Clint A. Stalnecker, Kristina Drizyte‐Miller, Marie Ménard, Julien Dilly, Stephen A. Sastra, Carmine F. Palermo, Marie C. Hasselluhn, Amanda R. Decker-Farrell, Stephanie Chang, Lingyan Jiang, Xing Wei, Yu Chi Yang, Ciara Helland, Haley Courtney, Yevgeniy Gindin, Karl Muonio, Ruiping Zhao, Samantha B. Kemp, Cynthia Clendenin, Rina Sor, William P. Vostrejs, Priya S. Hibshman, Amber M. Amparo, Connor J. Hennessey, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Jens Brodbeck, Lorenzo Tomassoni, Basil Bakir, Nicholas D. Socci, Laura E. Herring, Natalie K. Barker, Junning Wang, James M. Cleary, Brian M. Wolpin, John A. Chabot, Michael D. Kluger, Gulam A. Manji, Kenneth Y. Tsai, Miroslav Sekulic, Stephen M. Lagana, Andrea Califano, Elsa Quintana, Zhengping Wang, Jacqueline A.M. Smith, Matthew Holderfield, David Wildes, Scott W. Lowe, Michael A. Badgley, Andrew J. Aguirre, Robert H. Vonderheide, Ben Z. Stanger, Timour Baslan, Channing J. Der, Mallika Singh, Kenneth P. Olive - Nature 2024 cited by 175

  8. KRAS: feeding pancreatic cancer proliferation

    Authors: Kirsten L. Bryant, Joseph D. Mancias, Alec C. Kimmelman, Channing J. Der - Trends in Biochemical Sciences 2014 cited by 684

  9. Combination Therapies with CDK4/6 Inhibitors to Treat KRAS- Mutant Pancreatic Cancer

    Authors: Craig M. Goodwin, Andrew M. Waters, Jennifer E. Klomp, Sehrish Javaid, Kirsten L. Bryant, Clint A. Stalnecker, Kristina Drizyte‐Miller, Bjoern Papke, Runying Yang, Amber M. Amparo, Irem Ozkan‐Dagliyan, Elisa Baldelli, Valerie Calvert, Mariaelena Pierobon, Jessica A. Sorrentino, Andrew P. Beelen, Natalie Bublitz, Mareen Lüthen, Kris C. Wood, Emanuel F. Petricoin, Christine Sers, Autumn J. McRee, Adrienne D. Cox, Channing J. Der - Cancer Research 2022 cited by 160

  10. The Ras superfamily at a glance

    Authors: Krister Wennerberg, Kent L. Rossman, Channing J. Der - Journal of Cell Science 2005 cited by 1,531

  11. Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer

    Authors: G. Aaron Hobbs, Nicole M. Baker, Anne M. Miermont, Ryan D. Thurman, Mariaelena Pierobon, Timothy H. Tran, Andrew O. Anderson, Andrew M. Waters, J. Nathaniel Diehl, Bjoern Papke, Richard G. Hodge, Jennifer E. Klomp, Craig M. Goodwin, Jonathan M. DeLiberty, Junning Wang, Raymond W.S. Ng, Prson Gautam, Kirsten L. Bryant, Dominic Esposito, Sharon L. Campbell, Emanuel F. Petricoin, Dhirendra K. Simanshu, Andrew J. Aguirre, Brian M. Wolpin, Krister Wennerberg, Udo Rudloff, Adrienne D. Cox, Channing J. Der - Cancer Discovery 2019 cited by 226

  12. Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

    Authors: Dominico Vigil, Jacqueline Cherfils, Kent L. Rossman, Channing J. Der - Nature reviews. Cancer 2010 cited by 816

  13. Ras history

    Authors: Adrienne D. Cox, Channing J. Der - Small GTPases 2010 cited by 713

  14. Drugging RAS: Know the enemy

    Authors: Bjoern Papke, Channing J. Der - Science 2017 cited by 395

  15. KRAS inhibitors: resistance drivers and combinatorial strategies

    Authors: Tamara Isermann, Christine Sers, Channing J. Der, Bjoern Papke - Trends in cancer 2024 cited by 157

  16. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

    Authors: Angelina V. Vaseva, Devon R. Blake, Thomas S.K. Gilbert, Serina Ng, Galen Hostetter, Salma H. Azam, Irem Ozkan‐Dagliyan, Prson Gautam, Kirsten L. Bryant, Kenneth H. Pearce, Laura E. Herring, Haiyong Han, Lee M. Graves, Agnieszka K. Witkiewicz, Erik S. Knudsen, Chad V. Pecot, Naim U. Rashid, Peter J. Houghton, Krister Wennerberg, Adrienne D. Cox, Channing J. Der - Cancer Cell 2018 cited by 192

  17. Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer

    Authors: Luisa F. Escobar‐Hoyos, Alex Penson, Ram Kannan, Hana Cho, Chun‐Hao Pan, Rohit K. Singh, Lisa Helene Apken, G. Aaron Hobbs, Renhe Luo, Nicolas Lecomte, Sruthi Babu, Fong Cheng Pan, Direna Alonso‐Curbelo, John P. Morris, Gökçe Aşkan, Olivera Grbovic-Huezo, Paul Ogrodowski, Jonathan Bermeo, Joseph A. Saglimbeni, Cristian D. Cruz, Yu-Jui Ho, Sharon Lawrence, Jerry P. Melchor, Grant A. Goda, Karen Bai, Alessandro Pastore, Simon J. Hogg, Srivatsan Raghavan, Peter J. Bailey, David K. Chang, Andrew V. Biankin, Kenneth R. Shroyer, Brian M. Wolpin, Andrew J. Aguirre, Andrea Ventura, Barry S. Taylor, Channing J. Der, Daniel Domínguez, Daniel Kümmel, Andrea Oeckinghaus, Scott W. Lowe, Robert K. Bradley, Omar Abdel‐Wahab, Steven D. Leach - Cancer Cell 2020 cited by 158

  18. TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors

    Authors: A. Cole Edwards, Clint A. Stalnecker, Alexis Jean Morales, Khalilah E. Taylor, Jennifer E. Klomp, Jeffrey A. Klomp, Andrew M. Waters, Niranjan Sudhakar, Jill Hallin, Tracy T. Tang, Peter Olson, Leonard Post, James G. Christensen, Adrienne D. Cox, Channing J. Der - Cancer Research 2023 cited by 80

  19. GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

    Authors: Kent L. Rossman, Channing J. Der, John Sondek - Nature Reviews Molecular Cell Biology 2005 cited by 1,722

  20. Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer

    Authors: Haisheng Zhang, Antje Schaefer, Yichen Wang, Richard G. Hodge, Devon R. Blake, J. Nathaniel Diehl, Alex G. Papageorge, Matthew D. Stachler, Jennifer Liao, Jin Zhou, Zhong Wu, Fahire G. Akarca, Leonie K. de Klerk, Sarah Derks, Mariaelena Pierobon, Katherine A. Hoadley, Timothy C. Wang, George M. Church, Kwok‐Kin Wong, Emanuel F. Petricoin, Adrienne D. Cox, Douglas R. Lowy, Channing J. Der, Adam J. Bass - Cancer Discovery 2019 cited by 173

  21. Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

    Authors: Jeffrey A. Klomp, Jeffrey A. Klomp, Jennifer E. Klomp, Jennifer E. Klomp, Clint A. Stalnecker, Kirsten L. Bryant, A. Cole Edwards, Kristina Drizyte‐Miller, Priya S. Hibshman, J. Nathaniel Diehl, Ye S. Lee, Alexis Jean Morales, Khalilah E. Taylor, Sen Peng, Nhan L. Tran, Laura E. Herring, Alex W. Prevatte, Natalie K. Barker, Laura D. Hover, Jill Hallin, Saikat Chowdhury, Oluwadara Coker, Hey Min Lee, Craig M. Goodwin, Prson Gautam, Peter Olson, James G. Christensen, John Paul Shen, Scott Kopetz, Lee M. Graves, Kian‐Huat Lim, Andrea Wang‐Gillam, Krister Wennerberg, Adrienne D. Cox, Channing J. Der - Science 2024 cited by 108

  22. Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

    Authors: Tikvah K. Hayes, Nicole F. Neel, Chaoxin Hu, Prson Gautam, Mélissa Chénard, Brian J. Long, Meraj Aziz, Michelle Kassner, Kirsten L. Bryant, Mariaelena Pierobon, Raoud Marayati, Swapnil S. Kher, Samuel D. George, Ming Xu, Andrea Wang‐Gillam, Ahmed A. Samatar, Anirban Maitra, Krister Wennerberg, Emanuel F. Petricoin, Hongwei Yin, Barry D. Nelkin, Adrienne D. Cox, Jen Jen Yeh, Channing J. Der - Cancer Cell 2015 cited by 275

  23. Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer

    Authors: Jennifer E. Klomp, J. Nathaniel Diehl, Jeffrey A. Klomp, A. Cole Edwards, Runying Yang, Alexis Jean Morales, Khalilah E. Taylor, Kristina Drizyte‐Miller, Kirsten L. Bryant, Antje Schaefer, Jared L. Johnson, Emily M. Huntsman, Tomer M. Yaron, Mariaelena Pierobon, Elisa Baldelli, Alex W. Prevatte, Natalie K. Barker, Laura E. Herring, Emanuel F. Petricoin, Lee M. Graves, Lewis C. Cantley, Adrienne D. Cox, Channing J. Der, Clint A. Stalnecker - Science 2024 cited by 81

  24. Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

    Authors: Kaikobad Irani, Yong Xia, Jay L. Zweíer, Steven J. Sollott, Channing J. Der, Eric R. Fearon, Maitrayee Sundaresan, Toren Finkel, Pascal J. Goldschmidt‐Clermont - Science 1997 cited by 1,593