Christopher M. Dobson
Active 1973–2024
- Also published as
- Christopher M Dobson
- 469
- Papers
- 113,744
- Citations
- 169
- h-index
- 469
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Biochemistry, Genetics and Molecular Biology43.1%
- Medicine33.6%
- Materials Science6.1%
- Chemistry3.9%
- Neuroscience2.9%
- Computer Science2.3%
- Other8.1%
Topics
- Protein Structure and Dynamics9.7%
- Alzheimer's disease research and treatments9.7%
- Enzyme Structure and Function4.5%
- Parkinson's Disease Mechanisms and Treatments3.5%
- Computational Drug Discovery Methods2.9%
- Prion Diseases and Protein Misfolding2.4%
- Other67.3%
Coauthors
- Michele Vendruscolo144
- Tuomas P. J. Knowles109
- Fabrizio Chiti51
- Sara Linse34
- Janet R. Kumita31
- Carol V. Robinson30
- Georg Meisl29
- Alexander K. Buell28
- David Klenerman28
- Samuel I. A. Cohen27
- Nunilo Cremades25
- John Christodoulou24
- Michele Perni22
- Christina Redfield21
- Sheena E. Radford21
- Thomas C. T. Michaels21
- Jesús Zurdo20
- Mark R. Wilson20
- Paolo Arosio20
- Patrick Flagmeier20
- Cait E. MacPhee19
- Francesco A. Aprile18
- Mark E. Welland18
- Serene W. Chen18
All papers
- Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade
Authors: Fabrizio Chiti, Christopher M. Dobson - Annual Review of Biochemistry 2017 cited by 2,684
- Protein Misfolding, Functional Amyloid, and Human Disease
Authors: Fabrizio Chiti, Christopher M. Dobson - Annual Review of Biochemistry 2006 cited by 6,418
- The amyloid state and its association with protein misfolding diseases
Authors: Tuomas P. J. Knowles, Michele Vendruscolo, Christopher M. Dobson - Nature Reviews Molecular Cell Biology 2014 cited by 2,412
- Protein folding and misfolding
Authors: Christopher M. Dobson - Nature 2003 cited by 4,779
- Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
Authors: Samuel I. A. Cohen, Sara Linse, Leila M. Luheshi, Erik Hellstrand, Duncan A. White, Luke Rajah, Daniel E. Otzen, Michele Vendruscolo, Christopher M. Dobson, Tuomas P. J. Knowles - National Academy of Sciences, Proceedings of the National Academy of Sciences 2013 cited by 1,447
- Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
Authors: Giuliana Fusco, Serene W. Chen, Philip T. F. Williamson, Roberta Cascella, Michele Perni, James A. Jarvis, Cristina Cecchi, Michele Vendruscolo, Fabrizio Chiti, Nunilo Cremades, Liming Ying, Christopher M. Dobson, Alfonso De Simone - Science 2017 cited by 703
- Molecular mechanisms of protein aggregation from global fitting of kinetic models
Authors: Georg Meisl, Julius B. Kirkegaard, Paolo Arosio, Thomas C. T. Michaels, Michele Vendruscolo, Christopher M. Dobson, Sara Linse, Tuomas P. J. Knowles - Nature Protocols 2016 cited by 789
- Half a century of amyloids: past, present and future
Authors: Pu Chun Ke, Ruhong Zhou, Louise C. Serpell, Roland Riek, Tuomas P. J. Knowles, Hilal A. Lashuel, Ehud Gazit, Ian W. Hamley, Thomas P. Davis, Marcus Fändrich, Daniel E. Otzen, Matthew R. Chapman, Christopher M. Dobson, David Eisenberg, Raffaele Mezzenga - Chemical Society Reviews 2020 cited by 577
- Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
Authors: Céline Galvagnion, Alexander K. Buell, Georg Meisl, Thomas C. T. Michaels, Michele Vendruscolo, Tuomas P. J. Knowles, Christopher M. Dobson - Nature Chemical Biology 2015 cited by 685
- Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation
Authors: Alexander K. Buell, Céline Galvagnion, Ricardo Gaspar, Emma Sparr, Michele Vendruscolo, Tuomas P. J. Knowles, Sara Linse, Christopher M. Dobson - National Academy of Sciences, Proceedings of the National Academy of Sciences 2014 cited by 687
- Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein
Authors: Nunilo Cremades, Samuel I. A. Cohen, Emma Deas, Andrey Y. Abramov, Allen Y. Chen, Ángel Orte, Massimo Sandal, Richard W. Clarke, Paul Dunne, Francesco A. Aprile, Carlos W. Bertoncini, Nicholas Wood, Tuomas P. J. Knowles, Christopher M. Dobson, David Klenerman - Cell 2012 cited by 918
- Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide
Authors: Thomas C. T. Michaels, Anđela Šarić, Samo Curk, Katja Bernfur, Paolo Arosio, Georg Meisl, Alexander J. Dear, Samuel I. A. Cohen, Christopher M. Dobson, Michele Vendruscolo, Sara Linse, Tuomas P. J. Knowles - Nature Chemistry 2020 cited by 343
- An Analytical Solution to the Kinetics of Breakable Filament Assembly
Authors: Tuomas P. J. Knowles, Christopher A. Waudby, Glyn L. Devlin, Samuel I. A. Cohen, Adriano Aguzzi, Michele Vendruscolo, Eugene M. Terentjev, Mark E. Welland, Christopher M. Dobson - Science 2009 cited by 1,158
- Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies
Authors: Sara Linse, Tom Scheidt, Katja Bernfur, Michele Vendruscolo, Christopher M. Dobson, Samuel I. A. Cohen, Eimantas Šileikis, Martin Lundqvist, Fang Qian, Tiernan T. O’Malley, Thierry Bussière, Paul H. Weinreb, Catherine K. Xu, Georg Meisl, Sean R. A. Devenish, Tuomas P. J. Knowles, Oskar Hansson - Nature Structural & Molecular Biology 2020 cited by 197
- Widespread Proteome Remodeling and Aggregation in Aging C. elegans
Authors: Dirk Walther, Prasad Kasturi, Min Zheng, Stefan Pinkert, Giulia Vecchi, Prajwal Ciryam, Richard I. Morimoto, Christopher M. Dobson, Michele Vendruscolo, Matthias Mann, F. Ulrich Hartl - Cell 2015 cited by 606
- Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides
Authors: Georg Meisl, Xiaoting Yang, Erik Hellstrand, Birgitta Frohm, Julius B. Kirkegaard, Samuel I. A. Cohen, Christopher M. Dobson, Sara Linse, Tuomas P. J. Knowles - National Academy of Sciences, Proceedings of the National Academy of Sciences 2014 cited by 513
- Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour
Authors: Giuliana Fusco, Alfonso De Simone, Tata Gopinath, Vitaly V. Vostrikov, Michele Vendruscolo, Christopher M. Dobson, Gianluigi Veglia - Nature Communications 2014 cited by 478
- Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
Authors: Gabriella T. Heller, Francesco A. Aprile, Thomas C. T. Michaels, Ryan Limbocker, Michele Perni, Francesco Simone Ruggeri, Benedetta Mannini, Thomas Löhr, Massimiliano Bonomi, Carlo Camilloni, Alfonso De Simone, Isabella C. Felli, Roberta Pierattelli, Tuomas P. J. Knowles, Christopher M. Dobson, Michele Vendruscolo - Science Advances 2020 cited by 181
- The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells
Authors: Roberta Cascella, Serene W. Chen, Alessandra Bigi, José D. Camino, Catherine K. Xu, Christopher M. Dobson, Fabrizio Chiti, Nunilo Cremades, Cristina Cecchi - Nature Communications 2021 cited by 240
- Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation
Authors: Patrick Flagmeier, Georg Meisl, Michele Vendruscolo, Tuomas P. J. Knowles, Christopher M. Dobson, Alexander K. Buell, Céline Galvagnion - National Academy of Sciences, Proceedings of the National Academy of Sciences 2016 cited by 349
- Chemical space and biology
Authors: Christopher M. Dobson - Nature 2004 cited by 1,035
- Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease
Authors: Emma Deas, Nunilo Cremades, Plamena R. Angelova, Marthe H. R. Ludtmann, Zhi Yao, Serene W. Chen, Mathew H. Horrocks, Blerida Banushi, Daniel Little, Michael J. Devine, Paul Gissen, David Klenerman, Christopher M. Dobson, Nicholas Wood, Sonia Gandhi, Andrey Y. Abramov - Antioxidants and Redox Signaling 2015 cited by 362
- A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
Authors: Samuel I. A. Cohen, Paolo Arosio, Jenny Presto, Firoz Roshan Kurudenkandy, Henrik Biverstål, Lisa Dolfe, Christopher J.R. Dunning, Xiaoting Yang, Birgitta Frohm, Michele Vendruscolo, Jan Johansson, Christopher M. Dobson, André Fisahn, Tuomas P. J. Knowles, Sara Linse - Nature Structural & Molecular Biology 2015 cited by 424
- Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein
Authors: Céline Galvagnion, James W. Brown, Myriam Ouberaï, Patrick Flagmeier, Michele Vendruscolo, Alexander K. Buell, Emma Sparr, Christopher M. Dobson - National Academy of Sciences, Proceedings of the National Academy of Sciences 2016 cited by 320
