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Hakon Leffler

Active 1979–2025

121
Papers
19,857
Citations
84
h-index
118
i10-index

Citations

Citations per year for Hakon Leffler1936: 2 citations1978: 1 citations1980: 2 citations1981: 12 citations1982: 16 citations1983: 25 citations1984: 26 citations1985: 33 citations1986: 39 citations1987: 65 citations1988: 45 citations1989: 31 citations1990: 36 citations1991: 60 citations1992: 44 citations1993: 63 citations1994: 68 citations1995: 116 citations1996: 91 citations1997: 141 citations1998: 143 citations1999: 135 citations2000: 156 citations2001: 156 citations2002: 229 citations2003: 142 citations2004: 153 citations2005: 184 citations2006: 127 citations2007: 137 citations2008: 170 citations2009: 158 citations2010: 161 citations2011: 135 citations2012: 120 citations2013: 93 citations2014: 128 citations2015: 100 citations2016: 160 citations2017: 114 citations2018: 164 citations2019: 477 citations2020: 547 citations2021: 496 citations2022: 383 citations2023: 384 citations2024: 540 citations2025: 225 citations2026: 6 citations1937–1977: no citations, so these years are not shown1979: no citations, so this year is not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 1,435 citing papers, 26.9% of this breakdownChina: 434 citing papers, 8.1% of this breakdownSweden: 358 citing papers, 6.7% of this breakdownGermany: 338 citing papers, 6.3% of this breakdownUnited Kingdom: 311 citing papers, 5.8% of this breakdownJapan: 280 citing papers, 5.3% of this breakdownFrance: 208 citing papers, 3.9% of this breakdownCanada: 159 citing papers, 3% of this breakdownNetherlands: 158 citing papers, 3% of this breakdownItaly: 138 citing papers, 2.6% of this breakdownSpain: 130 citing papers, 2.4% of this breakdownDenmark: 114 citing papers, 2.1% of this breakdown
0%26.9%Other 23.9%

Institutions

Fields

  • Immunology and Microbiology40.8%
  • Biochemistry, Genetics and Molecular Biology25.9%
  • Medicine22.4%
  • Neuroscience3.5%
  • Chemistry1.5%
  • Agricultural and Biological Sciences1.4%
  • Other4.5%

Topics

  • Galectins and Cancer Biology14.3%
  • Glycosylation and Glycoproteins Research9.1%
  • Signaling Pathways in Disease3.9%
  • Toxin Mechanisms and Immunotoxins2.9%
  • Peptidase Inhibition and Analysis2.2%
  • Escherichia coli research studies2.2%
  • Other65.4%

Coauthors

All papers

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  1. Galectins at a glance

    Authors: Ludger Johannes, Ralf Jacob, Hakon Leffler - Journal of Cell Science 2018 cited by 613

  2. Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease

    Authors: Antonio Boza‐Serrano, Rocío Ruiz, Raquel Sánchez‐Varo, Juan García‐Revilla, Yiyi Yang, Itzia Jiménez-Ferrer, Agnes Paulus, Malin Wennström, Anna Vilalta, David H. Allendorf, José Carlos Dávila, John Stegmayr, Sebastián Jiménez, María Angustias Roca-Ceballos, Victoria Navarro, Maria Swanberg, Christine L. Hsieh, Luís Miguel Real, Elisabet Englund, Sara Linse, Hakon Leffler, Ulf J. Nilsson, Guy C. Brown, Antonia Gutiérrez, Javier Vitórica, José L. Venero, Tomas Deierborg - Acta Neuropathologica 2019 cited by 370

  3. Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis

    Authors: Nikhil Hirani, Alison C. MacKinnon, Lisa Nicol, Paul Ford, Hans Schambye, Anders N. Pedersen, Ulf J. Nilsson, Hakon Leffler, Tariq Sethi, Susan Tantawi, Lise Gravelle, Robert J. Slack, Ross Mills, Utsa Karmakar, Duncan C. Humphries, Fredrik R. Zetterberg, Lucy Keeling, Lyn Paul, Philip L. Molyneaux, Feng Li, Wendy Funston, Ian Forrest, A. John Simpson, Michael Gibbons, Toby M. Maher - European Respiratory Journal 2020 cited by 219

  4. Galectin-3, a marker for vacuole lysis by invasive pathogens

    Authors: Irit Paz, Martin Sachse, Nicolas Dupont, Joëlle Mounier, Cecilia Cederfur, Jost Enninga, Hakon Leffler, Françoise Poirier, Marie‐Christine Prévost, Frank Lafont, Philippe Sansonetti - Cellular Microbiology 2009 cited by 383

  5. Regulation of Transforming Growth Factor-β1–driven Lung Fibrosis by Galectin-3

    Authors: Alison C. MacKinnon, Michael Gibbons, Sarah L. Farnworth, Hakon Leffler, Ulf J. Nilsson, Tamara Delaine, A. John Simpson, Stuart J. Forbes, Nik Hirani, Jack Gauldie, Tariq Sethi - American Journal of Respiratory and Critical Care Medicine 2011 cited by 521

  6. Galectins: A family of animal β-galactoside-binding lectins

    Authors: Samuel H. Barondes, Vincent Castronovo, Douglas N.W. Cooper, Richard D. Cummings, Kurt Drickamer, Ten Felzi, Michael A. Gitt, Jun Hirabayashi, Colin Hughes, Ken-ichi Kasai, Hakon Leffler, Fu‐Tong Liu, Reuben Lotan, Arthur M. Mercurio, Michel Monsigny, Shiv Pillai, Françoise Poirer, Avraham Raz, Peter Rigby, James M. Rini, John L. Wang - Cell 1994 cited by 1,207

  7. Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation

    Authors: Miguel Ángel Burguillos, Martina Svensson, Tim Schulte, Antonio Boza‐Serrano, Albert García-Quintanilla, Edel Kavanagh, Martiniano Santiago, Nikenza Viceconte, Maria José Oliva-Martín, Ahmed M. Osman, Emma Salomonsson, Lahouari Amar, Annette Persson, Klas Blomgren, Adnane Achour, Elisabet Englund, Hakon Leffler, José L. Venero, Bertrand Joseph, Tomas Deierborg - Cell Reports 2015 cited by 357

  8. Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease

    Authors: Fredrik R. Zetterberg, Alison C. MacKinnon, Thomas Brimert, Lise Gravelle, Richard Johnsson, Barbro Kahl-Knutson, Hakon Leffler, Ulf J. Nilsson, Anders N. Pedersen, Kristoffer Peterson, James A. Roper, Hans Schambye, Robert J. Slack, Susan Tantawi - Journal of Medicinal Chemistry 2022 cited by 92

  9. Galectins. Structure and function of a large family of animal lectins.

    Authors: S H Barondes, D.N. Cooper, Michael A. Gitt, Hakon Leffler - Journal of Biological Chemistry 1994 cited by 1,496

  10. An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade

    Authors: Lynda Vuong, Eleni Kouverianou, Claire Rooney, Brian J. McHugh, Sarah Howie, Christopher D. Gregory, Stuart J. Forbes, Neil C. Henderson, Fredrik R. Zetterberg, Ulf J. Nilsson, Hakon Leffler, Paul Ford, Anders N. Pedersen, Lise Gravelle, Susan Tantawi, Hans Schambye, Tariq Sethi, Alison C. MacKinnon - Cancer Research 2019 cited by 141

  11. Interplay between Conformational Entropy and Solvation Entropy in Protein–Ligand Binding

    Authors: Maria Luisa Verteramo, Olof Stenström, Majda Misini Ignjatović, Octav Caldararu, Martin Olsson, Francesco Manzoni, Hakon Leffler, Esko Oksanen, Derek T. Logan, Ulf J. Nilsson, Ulf Ryde, Mikael Akke - Journal of the American Chemical Society 2019 cited by 138

  12. X-ray Crystal Structure of the Human Galectin-3 Carbohydrate Recognition Domain at 2.1-Å Resolution

    Authors: J. Seetharaman, A. I. Kanigsberg, Rita Slaaby, Hakon Leffler, Samuel H. Barondes, James M. Rini - Journal of Biological Chemistry 1998 cited by 422

  13. Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor: a single- and multiple-dose first-in-human study in healthy participants

    Authors: Vassilios Aslanis, Robert J. Slack, Alison C. MacKinnon, C McClinton, Susan Tantawi, Lise Gravelle, Ulf J. Nilsson, Hakon Leffler, Ashley Brooks, Sanjeev Khindri, Richard P. Marshall, Anders N. Pedersen, Hans Schambye, Fredrik R. Zetterberg - Cancer Chemotherapy and Pharmacology 2023 cited by 40

  14. Galectin-1, -2, and -3 Exhibit Differential Recognition of Sialylated Glycans and Blood Group Antigens

    Authors: Sean R. Stowell, Connie M. Arthur, Padmaja Mehta, Kristen A. Slanina, Ola Blixt, Hakon Leffler, David F. Smith, Richard D. Cummings - Journal of Biological Chemistry 2008 cited by 417

  15. The Carbohydrate-Binding Site in Galectin-3 Is Preorganized To Recognize a Sugarlike Framework of Oxygens: Ultra-High-Resolution Structures and Water Dynamics

    Authors: K. Saraboji, M. Håkansson, Samuel Genheden, Carl Diehl, Johan �Qvist, Ulrich Weininger, Ulf J. Nilsson, Hakon Leffler, Ulf Ryde, Mikael Akke, Derek T. Logan - Biochemistry 2011 cited by 162

  16. Ligand Induced Galectin-3 Protein Self-association

    Authors: Adriana Lepur, Emma Salomonsson, Ulf J. Nilsson, Hakon Leffler - Journal of Biological Chemistry 2012 cited by 161

  17. Monosaccharide Derivatives with Low‐Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine–Amide, Phenyl–Arginine, Sulfur–π, and Halogen Bond Interactions

    Authors: Fredrik R. Zetterberg, Kristoffer Peterson, Richard Johnsson, Thomas Brimert, M. Håkansson, Derek T. Logan, Hakon Leffler, Ulf J. Nilsson - ChemMedChem 2017 cited by 106

  18. Extracellular and intracellular small-molecule galectin-3 inhibitors

    Authors: John Stegmayr, Fredrik R. Zetterberg, Michael C. Carlsson, Xiaoli Huang, Gunjan Sharma, Barbro Kahl-Knutson, Hans Schambye, Ulf J. Nilsson, Stina Oredsson, Hakon Leffler - Scientific Reports 2019 cited by 105

  19. Galectin-9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix

    Authors: Dharma Pally, Mallar Banerjee, Shahid Hussain, Rekha V. Kumar, Alexandra Petersson, Ebba Rosendal, Ludvig Gunnarsson, Kristoffer Peterson, Hakon Leffler, Ulf J. Nilsson, Ramray Bhat - ACS Chemical Biology 2022 cited by 31

  20. Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity

    Authors: Kristoffer Peterson, Rohit Kumar, Olof Stenström, Priya Ranjan Prasad Verma, Prashant R. Verma, M. Håkansson, Barbro Kahl‐Knutsson, Fredrik R. Zetterberg, Hakon Leffler, Mikael Akke, Derek T. Logan, Ulf J. Nilsson - Journal of Medicinal Chemistry 2017 cited by 99

  21. Entropy–Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C

    Authors: Johan Wallerstein, Vilhelm Ekberg, Majda Misini Ignjatović, Rohit Kumar, Octav Caldararu, Kristoffer Peterson, Sven Wernersson, Ulrika Brath, Hakon Leffler, Esko Oksanen, Derek T. Logan, Ulf J. Nilsson, Ulf Ryde, Mikael Akke - JACS Au 2021 cited by 52

  22. Galectin‐3‐Binding Glycomimetics that Strongly Reduce Bleomycin‐Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition

    Authors: Tamara Delaine, P.M. Collins, Alison C. MacKinnon, Gunjan Sharma, John Stegmayr, Vishal Kumar Rajput, Santanu Mandal, Ian Cumpstey, A. Larumbe, Bader A. Salameh, Barbro Kahl‐Knutsson, Hilde van Hattum, Monique van Scherpenzeel, Roland J. Pieters, Tariq Sethi, Hans Schambye, Stina Oredsson, Hakon Leffler, Helen Blanchard, Ulf J. Nilsson - ChemBioChem 2016 cited by 198

  23. 1H-1,2,3-Triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors

    Authors: Bader A. Salameh, Ian Cumpstey, Anders Sundin, Hakon Leffler, Ulf J. Nilsson - Bioorganic & Medicinal Chemistry 2010 cited by 114

  24. Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression

    Authors: Seok‐Jun Kim, Hyeok-Gu Kang, Kyungeun Kim, Hoyoung Kim, Fredrik R. Zetterberg, Young Soo Park, Hyun‐Soo Cho, Stephen M. Hewitt, Joon‐Yong Chung, Ulf J. Nilsson, Hakon Leffler, Kyung‐Hee Chun - Gastric Cancer 2021 cited by 40