Holger Lerche

Active 1989–2025

159
Papers
21,370
Citations
89
h-index
154
i10-index

Citations

Citations per year for Holger Lerche1993: 3 citations1994: 4 citations1995: 5 citations1996: 13 citations1997: 13 citations1998: 2 citations1999: 10 citations2000: 17 citations2001: 15 citations2002: 31 citations2003: 21 citations2004: 61 citations2005: 60 citations2006: 58 citations2007: 48 citations2008: 87 citations2009: 84 citations2010: 119 citations2011: 117 citations2012: 127 citations2013: 161 citations2014: 176 citations2015: 234 citations2016: 195 citations2017: 260 citations2018: 191 citations2019: 749 citations2020: 845 citations2021: 799 citations2022: 588 citations2023: 449 citations2024: 790 citations2025: 268 citations2026: 2 citations

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 1,940 citing papers, 20.2% of this breakdownGermany: 845 citing papers, 8.8% of this breakdownUnited Kingdom: 821 citing papers, 8.5% of this breakdownItaly: 601 citing papers, 6.2% of this breakdownChina: 527 citing papers, 5.5% of this breakdownAustralia: 438 citing papers, 4.5% of this breakdownFrance: 432 citing papers, 4.5% of this breakdownCanada: 410 citing papers, 4.3% of this breakdownNetherlands: 344 citing papers, 3.6% of this breakdownBelgium: 211 citing papers, 2.2% of this breakdownSwitzerland: 209 citing papers, 2.2% of this breakdownSpain: 204 citing papers, 2.1% of this breakdown
0%20.2%Other 27.4%

Fields

  • Medicine41.7%
  • Biochemistry, Genetics and Molecular Biology35.9%
  • Neuroscience19.6%
  • Engineering0.7%
  • Psychology0.4%
  • Computer Science0.3%
  • Other1.4%

Topics

  • Epilepsy research and treatment12.4%
  • Neuroscience and Neuropharmacology Research8.3%
  • Ion channel regulation and function6.1%
  • Genomics and Rare Diseases5.3%
  • Genetics and Neurodevelopmental Disorders5.2%
  • Pharmacological Effects and Toxicity Studies2.9%
  • Other59.8%

Coauthors

All papers

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  1. Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery

    Authors: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Josef Zentner, Dieter Henrik Heiland, Horst Urbach, Bernhard J. Steinhoff, Thomas Bast, Laura Tassi, Giorgio Lo Russo, Çiğdem Özkara, Büğe Öz, Pavel Kršek, Silke Vogelgesang, Uwe Runge, Holger Lerche, Yvonne Weber, Mrinalini Honavar, José Pimentel, Alexis Arzimanoglou, Adriana Ulate-Campos, Soheyl Noachtar, Elisabeth Härtl, Olaf Schijns, Renzo Guerrini, Carmen Barba, Thomas S. Jacques, J. Helen Cross, Martha Feucht, Angelika Mühlebner, Thomas Grünwald, Eugen Trinka, Peter Winkler, António Gil‐Nagel, Rafael Toledano, Thomas Mayer, Martin Lutz, Basilios Zountsas, Kyriakos Garganis, Felix Rosenow, Anke Hermsen, Tim J. von Oertzen, Thomas L. Diepgen, G. Avanzini - New England Journal of Medicine 2017 cited by 917

  2. Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study

    Authors: , , , , , , , , , , , , , , , , , , , , , , , , , , , - The Lancet Neurology 2013 cited by 1,121

  3. Genetic and phenotypic heterogeneity suggest therapeutic implications in SCN2A-related disorders

    Authors: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Miriam Döcker, Thomas Bast, Tobias Loddenkemper, Lily C. Wong‐Kisiel, Friedrich Baumeister, Walid Fazeli, Pasquale Striano, Robertino Dilena, Elena Fontana, Federico Zara, Gerhard Kurlemann, Joerg Klepper, Jess G. Thoene, Daniel H. Arndt, Nicolas Deconinck, Thomas Schmitt‐Mechelke, Oliver Maier, Hiltrud Muhle, Beverly Wical, C. Finetti, Reinhard Brückner, Joachim Pietz, G. Golla, Dinesh Jillella, Karen Markussen Linnet, Perrine Charles, Ute Moog, Eve Õiglane‐Shlik, John F. Mantovani, Kristen Park, Marie Deprez, Damien Lederer, Sandrine Mary, Emmanuel Scalais, Laila Selim, Rudy Van Coster, Lieven Lagae, Marina Nikanorova, Helle Hjalgrim, Georg-Christoph Korenke, Marina Trivisano, Nicola Specchio, Berten Ceulemans, Thomas Dorn, Katherine L. Helbig, Katia Hardies, Hannah Stamberger, Peter De Jonghe, Sarah Weckhuysen, Johannes R. Lemke, Ingeborg Krägeloh‐Mann, Ingo Helbig, Gerhard Kluger, Holger Lerche, Rikke S. Møller - Brain 2017 cited by 575

  4. Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies

    Authors: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Chantal Depondt, Orrin Devinsky, Dennis Dlugos, Colin P. Doherty, Christian E. Elger, Johan G. Eriksson, Thomas N. Ferraro, Martha Feucht, Ben Francis, André Franke, Jacqueline A. French, Saskia Freytag, Verena Gaus, Eric B. Geller, Christian Gieger, Tracy A. Glauser, Simon Glynn, David B. Goldstein, Hongsheng Gui, Youling Guo, Kevin F. Haas, Håkon Håkonarson, Kerstin Hallmann, Sheryl R. Haut, Erin L. Heinzen, Ingo Helbig, Christian Hengsbach, Helle Hjalgrim, Michele Iacomino, Andrés Ingason, Jennifer Jamnadas-Khoda, Michael R. Johnson, Reetta Kälviäinen, Anne-Mari Kantanen, Dalia Kasperavičiūtė, Dorothée Kasteleijn‐Nolst Trenité, Heidi E. Kirsch, Robert C. Knowlton, Bobby P.C. Koeleman, Roland Krause, Martin Krenn, Wolfram S. Kunz, Ruben Kuzniecky, Patrick Kwan, Dennis Lal, YL Lau, Anna‐Elina Lehesjoki, Holger Lerche, Costin Leu, Wolfgang Lieb, Dick Lindhout, Warren Lo, Íscia Lopes‐Cendes, Daniel H. Lowenstein, Alberto Malovini, Anthony G Marson, Thomas Mayer, Mark McCormack, James L. Mills, Nasir Mirza, Martina Moerzinger, Rikke S. Møller, Anne M. Molloy, Hiltrud Muhle, Mark R. Newton, Ping-Wing Ng, Markus M. Nöthen, Peter Nürnberg, Terence J. O’Brien, Karen Oliver and 58 more - Nature Communications 2018 cited by 513

  5. GAA-FGF14 ataxia (SCA27B): phenotypic profile, natural history progression and 4-aminopyridine treatment response

    Authors: , , , , , , , , , , , , , , , , , , , , , , , , - Brain 2023 cited by 114

  6. Transcutaneous Vagus Nerve Stimulation (tVNS) for Treatment of Drug-Resistant Epilepsy: A Randomized, Double-Blind Clinical Trial (cMPsE02)

    Authors: , , , , , , , , , , , , , , , , - Brain stimulation 2016 cited by 272

  7. Precision medicine for genetic epilepsy on the horizon: Recent advances, present challenges, and suggestions for continued progress

    Authors: , , , , , , , , , , , , - Epilepsia 2022 cited by 140

  8. Risk of Major Congenital Malformations and Exposure to Antiseizure Medication Monotherapy

    Authors: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Maja Milovanović, Vladimír Šafčák, Meritxell Martínez Ferri, Torbjörn Tomson, Elisabeth Sellitto, Hsiang‐Yu Yu, Stephanie Hödl, Petr Marusič, Renata Listonova, Hana Krijtová, David Franc, Petr Bušek, Michaela Kajšová, Noémi Becser Andersen, Birthe Pedersen, Katarzyna Maria Mieszczanek, Katarzyna Cebula, Stefan Juhl, Birgitte Forsom Sondal, Karen Nielsen, Tatiana V. Danielsen, Elsebeth Bruun Christiansen, Jakob Christensen, Ovidio Solano Cabrera, Aleksei Rakitin, Anne Kirss, Anna Maija Saukkonen, Nino Gogatishvili, Dieter Dennig, Kerstin Erdmann, Christian M. Dippon, Bernhard J. Steinhoff, Lisa Langenbruch, Holger Lerche, Anja Herzer, Jan S. Gerdes, Elisa K. El-Allawy-Zielke, Hajo M. Hamer, Malgorzata Kalita, Martin Hirsch, Stephan Arnold, Hans‐Beatus Straub, Rebekka Lehmann, Christiane Asenbauer, Florian Losch, Wenke Grönheit, Matthias Lindenau, Ramshekhar N. Menon, Jafar Mehvari Habibabadi, Maria Paola Canevini, Elena Zambrelli, Katherine Turner, Michela Cecconi, A Paggi, Nicoletta Foschi, Antonio Gambardella, Simone Beretta, Angela Giglio, Gaia Fanella, Lorenzo Ferri, Francesca Bisulli, Alessandra Pistelli, Pietro Pignatta, Marta Maschio, Francesca Muzzi, Maria Sofia Cotelli, Etsuko Yamazaki, Kiyohito Terada, Yushi Inoue, Masahiro Mizobuchi and 56 more - JAMA Neurology 2024 cited by 113

  9. De Novo Mutations in Synaptic Transmission Genes Including DNM1 Cause Epileptic Encephalopathies

    Authors: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Deb Pal, Aarno Palotie, Manuela Pendziwiat, Angela Robbiano, Filip Roelens, Felix Rosenow, Kaja Selmer, Jose M. Serratosa, Sanjay Sisodiya, Ulrich Stephani, Katalin Sterbova, Pasquale Striano, Arvid Suls, Tiina Talvik, Sarah von Spiczak, Yvonne Weber, Sarah Weckhuysen, Federico Zara, Bassel Abou-Khalil, Brian K. Alldredge, Eva Andermann, Frederick Andermann, Dina Amron, Jocelyn F. Bautista, Samuel F. Berkovic, Judith Bluvstein, Alex Boro, Gregory Cascino, Damian Consalvo, Patricia Crumrine, Orrin Devinsky, Dennis Dlugos, Michael P. Epstein, Miguel Fiol, Nathan B. Fountain, Jacqueline French, Daniel Friedman, Eric B. Geller, Tracy Glauser, Simon Glynn, Kevin Haas, Sheryl R. Haut, Jean Hayward, Sandra L. Helmers, Sucheta Joshi, Andres Kanner, Heidi E. Kirsch, Robert C. Knowlton, Eric H. Kossoff, Rachel Kuperman, Ruben Kuzniecky, Daniel H. Lowenstein, Shannon M. McGuire, Paul V. Motika, Edward J. Novotny, Ruth Ottman, Juliann M. Paolicchi, Jack Parent, Kristen Park, Annapurna Poduri, Lynette Sadleir, Ingrid E. Scheffer, Renée A. Shellhaas, Elliott Sherr, Jerry J. Shih, Rani Singh, Joseph Sirven, Michael C. Smith, Joe Sullivan, Liu Lin Thio and 31 more - The American Journal of Human Genetics 2014 cited by 454

  10. Current practice in diagnostic genetic testing of the epilepsies

    Authors: , , , , , , , , , , , , , , , - Epileptic Disorders 2022 cited by 102

  11. Clinical spectrum and genotype–phenotype associations of KCNA2-related encephalopathies

    Authors: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Markus Wolff, Dragan Marjanović, Hande Çağlayan, Mutluay Arslan, Sérgio D.J. Pena, Sanjay M. Sisodiya, Simona Balestrini, Steffen Syrbe, Pierangelo Veggiotti, Johannes R. Lemke, Rikke S. Møller, Holger Lerche, Guido Rubboli - Brain 2017 cited by 164

  12. A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy

    Authors: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Danielle M. Andrade, Bernt A. Engelsen, Arielle Crespel, Matthias Lindenau, Ebba Lohmann, Veronica Saletti, João Massano, Michael Privitera, Alberto J. Espay, Birgit Kauffmann, Michael Duchowny, Rikke S. Møller, Rachel Straussberg, Zaid Afawi, Bruria Ben‐Zeev, Kaitlin E. Samocha, Mark J. Daly, Steven Petrou, Holger Lerche, Aarno Palotie, Anna-Elina Lehesjoki - Nature Genetics 2014 cited by 315

  13. Phenotypic spectrum of GABRA1

    Authors: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , José M. Serratosa, Pasquale Striano, Peter De Jonghe, Sarah Weckhuysen, Arvid Suls, Kai Muru, Inga Talvik, Tiina Talvik, Hiltrud Muhle, Ingo Borggraefe, Imma Rost, Renzo Guerrini, Holger Lerche, Johannes R. Lemke, Guido Rubboli, Snezana Maljevic - Neurology 2016 cited by 141

  14. Neuronal mechanisms of mutations in SCN8A causing epilepsy or intellectual disability

    Authors: , , , , , , , , , , , , , , , , , - Brain 2018 cited by 132

  15. Spectrum of GABAA receptor variants in epilepsy

    Authors: , , , , , , - Current Opinion in Neurology 2019 cited by 87

  16. 4-Aminopyridine is a promising treatment option for patients with gain-of-function KCNA2 -encephalopathy

    Authors: , , , , , , , , , , , , , , , , , , , , , , , , - Science Translational Medicine 2021 cited by 83

  17. Randomized phase III study 306

    Authors: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Inga Talvik, Stephan Arnold, A. Hufnagel, Frank Kerling, Holger Lerche, Soheyl Noachtar, Felix Rosenow, Joachim Springub, Bernhard J. Steinhoff, Konrad J. Werhahn, Raymond Tak Fai Cheung, Patrick Kwan, Ping Wing Ng, John S.D. Chan, Attila Balogh, István Kondákor, Magdolna Neuwirth, Péter Rajna, György Rásonyi, Joy Desai, Sudhir Kothari, Sita Sattaluri, Bhawna Sharma, Nandan Yardi, J. M. K. Murthy, Manmohan Mehndiratta, Kolichana Venkateshwaralu, Silvana Franceschetti, Guntis Karelis, Guntis Rozentals, Baiba Uskane, Rūta Mameniškienė, Irena Virketiene, Zariah Abdul Aziz, Kheng Seang Lim, Mei‐Ling Sharon Tai, Maria Epifania Collantes, Katerina Tanya P. Gosiengfiao, Anna Członkowska, Wiesław Drozdowski, Waldemar Fryze, Jacek Gawłowicz, Maria Mazurkiewicz‐Bełdzińska, E Motta, Carla Bentes, Luı́s Cunha, Georgine de Sousa, Jose Manuel Lopes Lima, Ioana Mı̂ndruță, Dezso Nagy, Sanda Maria Nica, E. D. Belousova, Kalinin Vv, Е. В. Левитина, Perunova Nb, Н. В. Пизова, И. Е. Повереннова, П. Н. Власов, Dragoslav Sokić, Ksenija Božić, N. Jović, Žarko Martinović, Mirjana Spasić, Seung Bong Hong, Joong Koo Kang, Sang Ho Kim, Sung Eun Kim, Byung-In Lee, Sang Kun Lee, Yong Won Cho and 25 more - Neurology 2012 cited by 429

  18. The phenotypic spectrum of SCN8A encephalopathy

    Authors: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Andrea Bevot, Markus Wolff, Helle Hjalgrim, Renzo Guerrini, Ingrid E. Scheffer, Heather C. Mefford, Rikke S. Møller, Aarno Palotie, Anna-Elina Lehesjoki, Arvid Suls, Bobby P.C. Koeleman, Carla Marini, Christel Depienne, Dana Craiu, Deb K. Pal, Dorota Hoffman‐Zacharska, Eric Leguern, Federico Zara, Felix Rosenow, Hande Çağlayan, Helle Hjalgrim, Hiltrud Muhle, Holger Lerche, Ingo Helbig, Johanna Jähn, Johannes R. Lemke, José M. Serratosa, Kaja Kristine Selmer, Karl Martin Klein, Katalin Štěrbová, Nina Barišić, Padhraig Gormley, Pasquale Striano, Patrick May, Peter De Jonghe, Renzo Guerrini, Rikke S. Møller, Roland Krause, Rudi Balling, Sanjay M. Sisodiya, Sarah von Spiczak, Sarah Weckhuysen, Stéphanie Baulac, Tiina Talvik, Ulrich Stephani, Vladimı́r Komárek, Yvonne Weber - Neurology 2015 cited by 285

  19. Gain-of-function variants in GABRD reveal a novel pathway for neurodevelopmental disorders and epilepsy

    Authors: , , , , , , , , , , , , , , , , , , , , , - Brain 2021 cited by 74

  20. Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes

    Authors: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Petia Dimova, Rosa Guerrero, José M. Serratosa, Tarja Linnankivi, Anna‐Elina Lehesjoki, Susanne Ruf, Markus Wolff, Sarah E. Buerki, Gabriele Wohlrab, Judith Kroell, Alexandre Datta, Barbara Fiedler, Gerhard Kurlemann, Gerhard Kluger, Andreas Hahn, D Edda Haberlandt, Christina Kutzer, Jürgen Sperner, Felicitas Becker, Yvonne Weber, Martha Feucht, Hannelore Steinböck, Birgit Neophythou, Gabriel M. Ronen, U Gruber‐Sedlmayr, Julia Geldner, Robert J Harvey, Per Hoffmann, Stefan Herms, Janine Altmüller, Mohammad R. Toliat, Hölger Thiele, Peter Nürnberg, Christian Wilhelm, Ulrich Stephani, Ingo Helbig, Holger Lerche, Fritz Zimprich, Bernd A. Neubauer, Saskia Biskup, Sarah von Spiczak - Nature Genetics 2013 cited by 440

  21. Polygenic burden in focal and generalized epilepsies

    Authors: , , , , , , , , , , , , , , , , , , , - Brain 2019 cited by 151

  22. Hyperexcitable interneurons trigger cortical spreading depression in an Scn1a migraine model

    Authors: , , , , , , , , , , , , , , , , , , , - Journal of Clinical Investigation 2021 cited by 64

  23. Genome-wide identification and phenotypic characterization of seizure-associated copy number variations in 741,075 individuals

    Authors: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Dennis Lal, Namrata Gupta, Benjamin M. Neale, Samuel F. Berkovic, Holger Lerche, Daniel H. Lowenstein, Gianpiero L. Cavalleri, Patrick Cossette, Chris Cotsapas, Peter De Jonghe, Tracy Dixon‐Salazar, Renzo Guerrini, Håkon Håkonarson, Erin L. Heinzen, Ingo Helbig, Patrick Kwan, Anthony G Marson, Slavé Petrovski, Sitharthan Kamalakaran, Sanjay M. Sisodiya, Randy Stewart, Sarah Weckhuysen, Chantal Depondt, Dennis J. Dlugos, Ingrid E. Scheffer, Pasquale Striano, Catharine Freyer, Roland Krause, Patrick May, Kevin E. McKenna, Brigid M. Regan, Caitlin A. Bennett, Stephanie L. Leech, Costin Leu, David Lewis‐Smith, Authors from individual Epi25 cohorts:, Australia: Melbourne (AUSAUS), Australia: Royal Melbourne (AUSRMB), Terence J. O’Brien, Marian Todaro, Belgium: Antwerp (BELATW), Hannah Stamberger, Belgium: Brussels (BELULB), Chantal Depondti, Canada: Andrade (CANUTN), Danielle M. Andrade, Quratulain Zulfiqar Ali, Tara Sadoway, Switzerland: Bern (CHEUBB), Heinz Krestel, André Schaller, Cyprus (CYPCYP), Savvas Papacostas, Ioanna Kousiappa, George A. Tanteles, Christou Yiolanda, Czech Republic: Prague (CZEMTH), Katalin Štěrbová, Markéta Vlčková, Lucie Sedláčková, Petra Laššuthová, Germany: Frankfurt/Marburg (DEUPUM), Karl Martin Klein, Felix Rosenow, Philipp S. Reif, Susanne Knake, Germany: Giessen (DEUUGS), Bernd A. Neubauer, Friedrich Zimprich, Martha Feucht and 233 more - Nature Communications 2023 cited by 56

  24. Desynchronization of temporal lobe theta-band activity during effective anterior thalamus deep brain stimulation in epilepsy

    Authors: , , , , , , , , , , , , - NeuroImage 2020 cited by 46