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Issei Komuro

Active 1988–2025

390
Papers
50,706
Citations
126
h-index
364
i10-index

Citations

Citations per year for Issei Komuro1955: 1 citations1971: 1 citations1988: 1 citations1989: 20 citations1990: 43 citations1991: 32 citations1992: 43 citations1993: 53 citations1994: 59 citations1995: 81 citations1996: 89 citations1997: 131 citations1998: 259 citations1999: 309 citations2000: 341 citations2001: 293 citations2002: 334 citations2003: 339 citations2004: 350 citations2005: 277 citations2006: 357 citations2007: 354 citations2008: 356 citations2009: 295 citations2010: 361 citations2011: 301 citations2012: 353 citations2013: 314 citations2014: 340 citations2015: 339 citations2016: 350 citations2017: 329 citations2018: 353 citations2019: 1,015 citations2020: 1,326 citations2021: 1,347 citations2022: 1,318 citations2023: 1,160 citations2024: 2,044 citations2025: 997 citations2026: 63 citations1956–1970: no citations, so these years are not shown1972–1987: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 5,584 citing papers, 25.9% of this breakdownChina: 2,930 citing papers, 13.6% of this breakdownJapan: 1,930 citing papers, 9% of this breakdownUnited Kingdom: 1,256 citing papers, 5.8% of this breakdownGermany: 1,091 citing papers, 5.1% of this breakdownItaly: 806 citing papers, 3.7% of this breakdownCanada: 761 citing papers, 3.5% of this breakdownFrance: 537 citing papers, 2.5% of this breakdownNetherlands: 526 citing papers, 2.4% of this breakdownAustralia: 485 citing papers, 2.2% of this breakdownSpain: 380 citing papers, 1.8% of this breakdownSouth Korea: 324 citing papers, 1.5% of this breakdown
0%25.9%Other 23%

Institutions

Fields

  • Medicine52.4%
  • Biochemistry, Genetics and Molecular Biology34.9%
  • Immunology and Microbiology5.3%
  • Neuroscience3.8%
  • Nursing0.6%
  • Engineering0.6%
  • Other2.4%

Topics

  • Cardiac Fibrosis and Remodeling2.8%
  • Cardiovascular Function and Risk Factors2.1%
  • Congenital heart defects research2%
  • Adipose Tissue and Metabolism1.5%
  • Telomeres, Telomerase, and Senescence1.5%
  • Autophagy in Disease and Therapy1.4%
  • Other88.7%

Coauthors

All papers

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  1. A cross-population atlas of genetic associations for 220 human phenotypes

    Authors: Saori Sakaue, Masahiro Kanai, Yosuke Tanigawa, Juha Karjalainen, Mitja Kurki, S. Koshiba, Akira Narita, Takahiro Konuma, Kenichi Yamamoto, Masato Akiyama, Kazuyoshi Ishigaki, Akari Suzuki, Ken Suzuki, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Takao Suzuki, Nobuaki Shinozaki, Hiroki Yamaguchi, Shiro Minami, Shigeo Murayama, Kozo Yoshimori, Satoshi Nagayama, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yukihiro Koretsune, FinnGen, Kaoru Ito, Chikashi Terao, Toshimasa Yamauchi, Issei Komuro, Takashi Kadowaki, Gen Tamiya, Masayuki Yamamoto, Yusuke Nakamura, Michiaki Kubo, Yoshinori Murakami, Kazuhiko Yamamoto, Yoichiro Kamatani, Aarno Palotie, Manuel A. Rivas, Mark J. Daly, Koichi Matsuda, Yukinori Okada - Nature Genetics 2021 cited by 2,383

  2. Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

    Authors: Krishna G. Aragam, Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke N. Wolford, Deepak Atri, E. Weeks, Minxian Wang, George Hindy, Wei Zhou, Christopher Grace, Carolina Roselli, Nicholas Marston, Frederick Kamanu, Ida Surakka, Loreto Muñoz Venegas, Paul Sherliker, Satoshi Koyama, Kazuyoshi Ishigaki, Bjørn Olav Åsvold, Michael R. Brown, Ben Brumpton, Paul S. de Vries, Olga Giannakopoulou, Tota Giardoglou, Daníel F. Guðbjartsson, Ulrich Güldener, Syed M. Ijlal Haider, Anna Helgadóttir, M Ibrahim, Adnan Kastrati, Thorsten Kessler, Theodosios Kyriakou, Tomasz Konopka, Ling Li, Lijiang Ma, Thomas Meitinger, Sören Mucha, Matthias Munz, Federico Murgia, Jonas B. Nielsen, Markus M. Nöthen, Shichao Pang, Tobias Reinberger, Gavin R. Schnitzler, Damian Smedley, Guðmar Þorleifsson, Moritz von Scheidt, Jacob C. Ulirsch, Biobank Japan, EPIC-CVD, John Danesh, Davíð O. Arnar, Noël P. Burtt, Maria C. Costanzo, Jason Flannick, Kaoru Ito, Dongkeun Jang, Yoichiro Kamatani, Amit V. Khera, Issei Komuro, Iftikhar J. Kullo, Luca A. Lotta, Christopher P. Nelson, Robert Roberts, Guðmundur Þorgeirsson, Unnur Þorsteinsdóttir, Tom R. Webb, Aris Baras, Johan Björkegren, Eric Boerwinkle, George Dedoussis, Hilma Hólm, Kristian Hveem, Olle Melander, Alanna C. Morrison, Marju Orho‐Melander, Lοukianos S. Rallidis, Arno Ruusalepp, Marc S. Sabatine, Kāri Stefánsson, Pierre Zalloua, Patrick T. Ellinor, Martin Farrall, John Danesh, Christian T. Ruff, Hilary K. Finucane, Jemma C. Hopewell, Robert Clarke, Rajat M. Gupta, Jeanette Erdmann, Nilesh J. Samani, Heribert Schunkert, Hugh Watkins, Cristen J. Willer, Panos Deloukas, Sekar Kathiresan, Adam S. Butterworth, Paul S. de Vries, Moritz von Scheidt - Nature Genetics 2022 cited by 706

  3. Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

    Authors: Takafumi Oka, Shungo Hikoso, Osamu Yamaguchi, Manabu Taneike, Toshihiro Takeda, Takahito Tamai, Jota Oyabu, Tomokazu Murakawa, Hiroyuki Nakayama, Kazuhiko Nishida, Shizuo Akira, Akitsugu Yamamoto, Issei Komuro, Kinya Otsu - Nature 2012 cited by 1,191

  4. Endothelial Cell Senescence in Human Atherosclerosis

    Authors: Tohru Minamino, Hideaki Miyauchi, Toshihiko Yoshida, Yasuo Ishida, Hideo Yoshida, Issei Komuro - Circulation 2002 cited by 1,039

  5. NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload

    Authors: Yasutomi Higashikuni, Wenhao Liu, Genri Numata, Kimie Tanaka, Daiju Fukuda, Yu Tanaka, Yoichiro Hirata, Teruhiko Imamura, Eiki Takimoto, Issei Komuro, Masataka Sata - Circulation 2022 cited by 198

  6. Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease

    Authors: Satoshi Koyama, Kaoru Ito, Chikashi Terao, Masato Akiyama, Momoko Horikoshi, Yukihide Momozawa, Hiroshi Matsunaga, Hirotaka Ieki, Kouichi Ozaki, Yoshihiro Onouchi, Atsushi Takahashi, Seitaro Nomura, Hiroyuki Morita, Hiroshi Akazawa, Changhoon Kim, Jeong‐Sun Seo, Koichiro Higasa, Motoki Iwasaki, Taiki Yamaji, Norie Sawada, Shoichiro Tsugane, Teruhide Koyama, Hiroaki Ikezaki, Naoyuki Takashima, Keitaro Tanaka, Kokichi Arisawa, Kiyonori Kuriki, Mariko Naito, Kenji Wakai, Shinichiro Suna, Yasuhiko Sakata, Hiroshi Sato, Masatsugu Hori, Yasushi Sakata, Koichi Matsuda, Yoshinori Murakami, Hiroyuki Aburatani, Michiaki Kubo, Fumihiko Matsuda, Yoichiro Kamatani, Issei Komuro - Nature Genetics 2020 cited by 402

  7. A crucial role for adipose tissue p53 in the regulation of insulin resistance

    Authors: Tohru Minamino, Masayuki Orimo, Ippei Shimizu, Takeshige Kunieda, Masataka Yokoyama, Takashi Ito, Aika Nojima, Akira Nabetani, Yuichi Oike, Hisahiro Matsubara, Fuyuki Ishikawa, Issei Komuro - Nature Medicine 2009 cited by 880

  8. JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure ― Digest Version ―

    Authors: Hiroyuki Tsutsui, Mitsuaki Isobe, Hiroshi Ito, Hiroshi Ito, Ken Okumura, Minoru Ōno, Masafumi Kitakaze, Koichiro Kinugawa, Yasuki Kihara, Yoichi Goto, Issei Komuro, Yoshikatsu Saiki, Yoshihiko Saito, Yasushi Sakata, Naoki Sato, Yoshiki Sawa, Akira Shiose, Wataru Shimizu, Hiroaki Shimokawa, Yoshihiko Seino, Koichi Node, Taiki Higo, Atsushi Hirayama, Miyuki Makaya, Tohru Masuyama, Toyoaki Murohara, Shin‐ichi Momomura, Masafumi Yano, Kenji Yamazaki, Kazuhiro Yamamoto, Tsutomu Yoshikawa, Michihiro Yoshimura, Masatoshi Akiyama, Toshihisa Anzai, Shiro Ishihara, Takayuki Inomata, Teruhiko Imamura, Yu‐ki Iwasaki, Tomohito Ohtani, Katsuya Onishi, Takatoshi Kasai, Mahoto Kato, Makoto Kawai, Yoshiharu Kinugasa, Shintaro Kinugawa, Toru Kuratani, Shigeki Kobayashi, Yasuhiko Sakata, Atsushi Tanaka, Köichi Toda, Takashi Noda, Kotaro Nochioka, Masaru Hatano, Takayuki Hidaka, Takeo Fujino, Shigeru Makita, Osamu Yamaguchi, Uichi Ikeda, Takeshi Kimura, Shun Kohsaka, Masami Kosuge, Masakazu Yamagishi, Akira Yamashina, on behalf of the Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group - Circulation Journal 2019 cited by 704

  9. Genome-wide analysis identifies novel susceptibility loci for myocardial infarction

    Authors: Jaana Hartiala, Yi Han, Qiong Jia, James R. Hilser, Pin Huang, Janet Gukasyan, William Schwartzman, Zhiheng Cai, Subarna Biswas, David‐Alexandre Trégouët, Nicholas L. Smith, Marcus Seldin, Calvin Pan, Margarete Mehrabian, Aldons J. Lusis, Peter Bazeley, Yan V. Sun, Chang Liu, Arshed A. Quyyumi, Markus Scholz, Joachim Thiery, Graciela E. Delgado, Marcus E. Kleber, Winfried März, Laurence J Howe, Folkert W. Asselbergs, Marion van Vugt, Georgios J. Vlachojannis, Riyaz Patel, Leo‐Pekka Lyytikäinen, Mika Kähönen, Terho Lehtimäki, Tuomo Nieminen, Pekka Kuukasjärvi, Jari Laurikka, Xuling Chang, Chew‐Kiat Heng, Rong Jiang, William E. Kraus, Elizabeth R. Hauser, Jane F. Ferguson, Muredach P. Reilly, Kaoru Ito, Satoshi Koyama, Yoichiro Kamatani, Issei Komuro, Biobank Japan, Lindsey K. Stolze, Casey E. Romanoski, Mohammad Daud Khan, Adam W. Turner, Clint L. Miller, Rédouane Aherrahrou, Mete Civelek, Lijiang Ma, Johan Björkegren, S. Ram Kumar, W.H. Wilson Tang, Stanley L. Hazen, Hooman Allayee - European Heart Journal 2020 cited by 278

  10. Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis

    Authors: Toshiyuki Ko, Seitaro Nomura, Shintaro Yamada, Kanna Fujita, Takanori Fujita, Masahiro Satoh, Chio Oka, Manami Katoh, Masamichi Ito, Mikako Katagiri, Tatsuro Sassa, Bo Zhang, Satoshi Hatsuse, Takanobu Yamada, Mutsuo Harada, Haruhiro Toko, Eisuke Amiya, Masaru Hatano, Osamu Kinoshita, Kan Nawata, Hiroyuki Abé, Tetsuo Ushiku, Minoru Ōno, Masashi Ikeuchi, Hiroyuki Morita, Hiroyuki Aburatani, Issei Komuro - Nature Communications 2022 cited by 142

  11. HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

    Authors: Hiroaki Semba, Norihiko Takeda, Takayuki Isagawa, Yuki Sugiura, Kurara Honda, Masaki Wake, Hidenobu Miyazawa, Yoshifumi Yamaguchi, Masayuki Miura, Dana Jenkins, Hyunsung Choi, Jung‐whan Kim, Masataka Asagiri, Andrew S. Cowburn, Hajime Abe, Katsura Soma, Katsuhiro Koyama, Manami Katoh, Keimon Sayama, Nobuhito Goda, Randall S. Johnson, Ichiro Manabe, Ryozo Nagai, Issei Komuro - Nature Communications 2016 cited by 386

  12. Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction

    Authors: Kazuo Miyazawa, Kaoru Ito, Masamichi Ito, Zhaonan Zou, Masayuki Kubota, Seitaro Nomura, Hiroshi Matsunaga, Satoshi Koyama, Hirotaka Ieki, Masato Akiyama, Yoshinao Koike, Ryo Kurosawa, Hiroki Yoshida, Kouichi Ozaki, Yoshihiro Onouchi, BioBank Japan Project, Koichi Matsuda, Yoshinori Murakami, Yoichiro Kamatani, Atsushi Takahashi, Koichi Matsuda, Yoshinori Murakami, Hiroyuki Aburatani, Michiaki Kubo, Yukihide Momozawa, Chikashi Terao, Shinya Oki, Hiroshi Akazawa, Yoichiro Kamatani, Issei Komuro - Nature Genetics 2023 cited by 130

  13. Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling

    Authors: Yusuke Adachi, Kazutaka Ueda, Seitaro Nomura, Kaoru Ito, Manami Katoh, Mikako Katagiri, Shintaro Yamada, Masaki Hashimoto, Bowen Zhai, Genri Numata, Akira Otani, Munetoshi Hinata, Yuta Hiraike, Hironori Waki, Norifumi Takeda, Hiroyuki Morita, Tetsuo Ushiku, Toshimasa Yamauchi, Eiki Takimoto, Issei Komuro - Nature Communications 2022 cited by 132

  14. Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention

    Authors: Nicholas Marston, James P. Pirruccello, Giorgio Melloni, Satoshi Koyama, Frederick Kamanu, Lu‐Chen Weng, Carolina Roselli, Yoichiro Kamatani, Issei Komuro, Krishna G. Aragam, Adam S. Butterworth, Kaoru Ito, Steve A. Lubitz, Patrick T. Ellinor, Marc S. Sabatine, Christian T. Ruff - JAMA Cardiology 2022 cited by 131

  15. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload

    Authors: Masanori Sano, Tohru Minamino, Haruhiro Toko, Hideyuki Miyauchi, Masayuki Orimo, Yingjie Qin, Hiroshi Akazawa, Kaoru Tateno, Yosuke Kayama, Mutsuo Harada, Ippei Shimizu, Takayuki Asahara, Hirofumi Hamada, Shuhei Tomita, Jeffery D. Molkentin, Yunzeng Zou, Issei Komuro - Nature 2007 cited by 903

  16. Inhibition of autophagy in the heart induces age-related cardiomyopathy

    Authors: Manabu Taneike, Osamu Yamaguchi, Atsuko Nakai, Shungo Hikoso, Toshihiro Takeda, Isamu Mizote, Takafumi Oka, Takahito Tamai, Jota Oyabu, Tomokazu Murakawa, Kazuhiko Nishida, Takahiko Shimizu, Masatsugu Hori, Issei Komuro, Takuji Shirasawa, Noboru Mizushima, Kinya Otsu - Autophagy 2010 cited by 450

  17. Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure

    Authors: Takehiro Kamo, Hiroshi Akazawa, Wataru Suda, Akiko Saga-Kamo, Yu Shimizu, Hiroki Yagi, Qing Liu, Seitaro Nomura, Atsuhiko T. Naito, Norifumi Takeda, Mutsuo Harada, Haruhiro Toko, Hidetoshi Kumagai, Yuichi Ikeda, Eiki Takimoto, Jun‐ichi Suzuki, Kenya Honda, Hidetoshi Morita, Masahira Hattori, Issei Komuro - PLoS ONE 2017 cited by 266

  18. Angiogenesis and Cardiac Hypertrophy

    Authors: Toru Oka, Hiroshi Akazawa, Atsuhiko T. Naito, Issei Komuro - Circulation Research 2014 cited by 460

  19. A heart–brain–kidney network controls adaptation to cardiac stress through tissue macrophage activation

    Authors: Katsuhito Fujiu, Munehiko Shibata, Yukiteru Nakayama, Fusa Ogata, Sahohime Matsumoto, Koji Noshita, Shingo Iwami, Susumu Nakae, Issei Komuro, Ryozo Nagai, Ichiro Manabe - Nature Medicine 2017 cited by 176

  20. Cardiac macrophages prevent sudden death during heart stress

    Authors: Junichi Sugita, Katsuhito Fujiu, Yukiteru Nakayama, Takumi Matsubara, Jun Matsuda, Tsukasa Oshima, Yuxiang Liu, Yujin Maru, Eriko Hasumi, Toshiya Kojima, Hiroshi Seno, Keisuke Asano, Ayumu Ishijima, Naoki Tomii, Masatoshi Yamazaki, Fujimi Kudo, Ichiro Sakuma, Ryozo Nagai, Ichiro Manabe, Issei Komuro - Nature Communications 2021 cited by 103

  21. Vascular Cell Senescence

    Authors: Tohru Minamino, Issei Komuro - Circulation Research 2007 cited by 527

  22. Heart failure and chronic kidney disease manifestation and mortality risk associations in type 2 diabetes: A large multinational cohort study

    Authors: Kåre I. Birkeland, Johan Bodegård, Jan W. Eriksson, Anna Norhammar, Hermann Haller, Gerard C.M. Linssen, Amitava Banerjee, Marcus Thuresson, Suguru Okami, Elena Garal‐Pantaler, Jetty A. Overbeek, Jil Billy Mamza, Ruiqi Zhang, Toshitaka Yajima, Issei Komuro, Takashi Kadowaki - Diabetes Obesity and Metabolism 2020 cited by 227

  23. Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure

    Authors: Seitaro Nomura, Masahiro Satoh, Takanori Fujita, Tomoaki Higo, Tomokazu S. Sumida, Toshiyuki Ko, Toshihiro Yamaguchi, Takashige Tobita, Atsuhiko T. Naito, Masamichi Ito, Kanna Fujita, Mutsuo Harada, Haruhiro Toko, Yoshio Kobayashi, Kaoru Ito, Eiki Takimoto, Hiroshi Akazawa, Hiroyuki Morita, Hiroyuki Aburatani, Issei Komuro - Nature Communications 2018 cited by 284

  24. Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension

    Authors: Takahiro Hashimoto-Kataoka, Naoki Hosen, Takashi Sonobe, Yoh Arita, Taku Yasui, Takeshi Masaki, Masato Minami, Tadakatsu Inagaki, Shigeru Miyagawa, Yoshiki Sawa, Masaaki Murakami, Atsushi Kumanogoh, Keiko Yamauchi‐Takihara, Meinoshin Okumura, Tadamitsu Kishimoto, Issei Komuro, Mikiyasu Shirai, Yasushi Sakata, Yoshikazu Nakaoka - National Academy of Sciences, Proceedings of the National Academy of Sciences 2015 cited by 257