Jacek Biernat
Active 1990–2024
- 90
- Papers
- 24,166
- Citations
- 82
- h-index
- 90
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Medicine50.9%
- Biochemistry, Genetics and Molecular Biology36.4%
- Neuroscience5.6%
- Chemistry2.2%
- Computer Science1.4%
- Agricultural and Biological Sciences0.9%
- Other2.6%
Topics
- Alzheimer's disease research and treatments17.5%
- Microtubule and mitosis dynamics3.7%
- Cholinesterase and Neurodegenerative Diseases3.7%
- Protein Structure and Dynamics3.7%
- Neuroscience and Neuropharmacology Research3.7%
- RNA Research and Splicing3%
- Other64.7%
Coauthors
- Eckhard Mandelkow�76
- Eva‐Maria Mandelkow45
- Markus Zweckstetter26
- Martin von Bergen�14
- Christian Griesinger11
- Bernhard Trinczek8
- Gerard Drewes8
- Marco D. Mukrasch8
- Marcus Pickhardt8
- N. Gustke8
- Helmut E. Meyer7
- Stefan Bibow7
- Harindranath Kadavath6
- Inna Khlistunova6
- Katharina Tepper6
- Martin Blackledge6
- Elias Akoury5
- Stefan Barghorn5
- Barbara Steiner4
- Laurent Meijer4
- M. Schwalbe4
- Qingyi Zheng‐Fischhöfer4
- Subashchandrabose Chinnathambi4
- Susanne Illenberger4
All papers
- A current view on Tau protein phosphorylation in Alzheimer's disease
Authors: Susanne Wegmann, Jacek Biernat, Eckhard Mandelkow� - Current Opinion in Neurobiology 2021 cited by 439
- Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau
Authors: Susmitha Ambadipudi, Jacek Biernat, Dietmar Riedel, Eckhard Mandelkow�, Markus Zweckstetter - Nature Communications 2017 cited by 809
- Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS
Authors: Madhurima Chatterjee, Selcuk Özdemir, Christian Fritz, Wiebke Möbius, Luca Kleineidam, Eckhard Mandelkow�, Jacek Biernat, Cem Doğdu, Oliver Peters, Nicoleta Carmen Cosma, Xiao Wang, Luisa‐Sophie Schneider, Josef Priller, Eike Jakob Spruth, Andrea A. Kühn, Patricia Krause, Thomas Klockgether, Ina R. Vogt, Okka Kimmich, Annika Spottke, Daniel C. Hoffmann, Klaus Fließbach, Carolin Miklitz, Cornelia McCormick, Patrick Weydt, Björn Falkenburger, Moritz Brandt, René Guenther, Elisabeth Dinter, Jens Wiltfang, Niels Hansen, Mathias Bähr, Inga Zerr, Agnes Flöel, Peter J. Nestor, Emrah Düzel, Wenzel Glanz, Enise I. Incesoy, Katharina Bürger, Daniel Janowitz, Robert Perneczky, Boris‐Stephan Rauchmann, Franziska Hopfner, Olivia Wagemann, Johannes Levin, Stefan Teipel, Ingo Kilimann, Doreen Göerß, Johannes Prudlo, Thomas Gasser, Kathrin Brockmann, David Mengel, Milan Zimmermann, Matthis Synofzik, Carlo Wilke, Judit Selma‐González, Janina Turón‐Sans, Miguel Santos‐Santos, Daniel Alcolea, Sara Rubio‐Guerra, Juan Fortea, Álvaro Carbayo, Alberto Lleó, Ricardo Rojas‐García, Ignacio Illán‐Gala, Michael Wagner, Ingo Frommann, Sandra Roeske, L Bertram, Michael T. Heneka, Frederic Brosseron, Alfredo Ramı́rez, Matthias Schmid, Rudi Beschorner, Annett Halle, Jochen Herms, Manuela Neumann, Nicolas R. Barthélemy, Randall J. Bateman, Patrizia Rizzu, Peter Heutink, Oriol Dols‐Icardo, Günter U. Höglinger, Andreas Hermann, Anja Schneider - Nature Medicine 2024 cited by 185
- Tau stabilizes microtubules by binding at the interface between tubulin heterodimers
Authors: Harindranath Kadavath, Romina Hofele, Jacek Biernat, Satish Kumar, Katharina Tepper, Henning Urlaub, Eckhard Mandelkow�, Markus Zweckstetter - National Academy of Sciences, Proceedings of the National Academy of Sciences 2015 cited by 545
- Assembly of τ protein into Alzheimer paired helical filaments depends on a local sequence motif ( 306 VQIVYK 311 ) forming β structure
Authors: Martin von Bergen�, Peter Friedhoff, Jacek Biernat, Joachim Heberle, Eckhard Mandelkow�, Eckhard Mandelkow� - National Academy of Sciences, Proceedings of the National Academy of Sciences 2000 cited by 1,019
- Lysine/RNA-interactions drive and regulate biomolecular condensation
Authors: Tina Ukmar, Saskia Hutten, Matthew P. Grieshop, Nasrollah Rezaei‐Ghaleh, Maria‐Sol Cima‐Omori, Jacek Biernat, Eckhard Mandelkow�, Johannes Söding, Dorothee Dormann, Markus Zweckstetter - Nature Communications 2019 cited by 265
- Structural Polymorphism of 441-Residue Tau at Single Residue Resolution
Authors: Marco D. Mukrasch, Stefan Bibow, Jegannath Korukottu, Sadasivam Jeganathan�, Jacek Biernat, Christian Griesinger, Eckhard Mandelkow�, Markus Zweckstetter - PLoS Biology 2009 cited by 656
- RNA stimulates aggregation of microtubule‐associated protein tau into Alzheimer‐like paired helical filaments
Authors: T. Kampers, Peter Friedhoff, Jacek Biernat, Eckhard Mandelkow�, Eva‐Maria Mandelkow, E. Mandelkow, E. Mandelkow - FEBS Letters 1996 cited by 546
- Mutations of Tau Protein in Frontotemporal Dementia Promote Aggregation of Paired Helical Filaments by Enhancing Local β-Structure
Authors: Martin von Bergen�, Stefan Barghorn, Li Li, Alexander Marx, Jacek Biernat, Eva‐Maria Mandelkow, Eckhard Mandelkow�, Eckhard Mandelkow�, Eckhard Mandelkow� - Journal of Biological Chemistry 2001 cited by 580
- Phosphorylation that Detaches Tau Protein from Microtubules (Ser262, Ser214) Also Protects It against Aggregation into Alzheimer Paired Helical Filaments
Authors: Anja Schneider, Jacek Biernat, Martin von Bergen�, Eva‐Maria Mandelkow, Eva‐Maria Mandelkow - Biochemistry 1999 cited by 568
- Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action
Authors: G Elif Karagöz, Afonso M.S. Duarte, Elias Akoury, Hans Ippel, Jacek Biernat, Tania Morán Luengo, Martina Radli, Tatiana Didenko, Bryce A. Nordhues, Dmitry B. Veprintsev, Chad A. Dickey, Eckhard Mandelkow�, Markus Zweckstetter, Rolf Boelens, Tobias Madl, Stefan Rüdiger - Cell 2014 cited by 336
- Disease‐Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates
Authors: Adriana Savastano, David Flores‐Solis, Harindranath Kadavath, Jacek Biernat, Eckhard Mandelkow�, Markus Zweckstetter - Angewandte Chemie International Edition 2020 cited by 98
- Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding
Authors: Jacek Biernat, N. Gustke, Gerard Drewes, Eva‐Maria Mandelkow, Eckhard Mandelkow� - Neuron 1993 cited by 791
- Domains of tau Protein and Interactions with Microtubules
Authors: N. Gustke, Bernhard Trinczek, Jacek Biernat, Eva‐Maria Mandelkow, Eckhard Mandelkow� - Biochemistry 1994 cited by 663
- Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation
Authors: Sadasivam Jeganathan�, Antje Hascher, Subashchandrabose Chinnathambi, Jacek Biernat, Eva‐Maria Mandelkow, Eva‐Maria Mandelkow, Eckhard Mandelkow�, Eckhard Mandelkow� - Journal of Biological Chemistry 2008 cited by 281
- Structure, Microtubule Interactions, and Paired Helical Filament Aggregation by Tau Mutants of Frontotemporal Dementias
Authors: Stefan Barghorn, Qingyi Zheng‐Fischhöfer, Michael Ackmann, Jacek Biernat, Martin von Bergen�, Eckhard Mandelkow�, Eckhard Mandelkow� - Biochemistry 2000 cited by 351
- Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease
Authors: Sophie Leclerc, Matthieu Garnier, Ralph Hoessel, Doris Marko, James Bibb, Gretchen L. Snyder, Paul Greengard, Jacek Biernat, Yong‐Zhong Wu, Eva‐Maria Mandelkow, Gerhard Eisenbrand, Laurent Meijer - Journal of Biological Chemistry 2001 cited by 723
- Sites of Tau Important for Aggregation Populate β-Structure and Bind to Microtubules and Polyanions
Authors: Marco D. Mukrasch, Jacek Biernat, Martin von Bergen�, Christian Griesinger, Eckhard Mandelkow�, Markus Zweckstetter - Journal of Biological Chemistry 2005 cited by 324
- Tau and Membranes: Interactions That Promote Folding and Condensation
Authors: Chad A. Sallaberry, Barbie J. Voss, Jarosław Majewski, Jacek Biernat, Eckhard Mandelkow�, Eva Y., Crystal M. Vander Zanden - Frontiers in Cell and Developmental Biology 2021 cited by 61
- Microtubule-associated Protein/Microtubule Affinity-regulating Kinase (p110mark)
Authors: Helmut E. Meyer, Eva‐Maria Mandelkow, Eva-Maria Mandelkow, Gerard Drewes, Bernhard Trinczek, Susanne Illenberger, Jacek Biernat, Gerold Schmitt‐Ulms, Eckhard Mandelkow, Eckhard Mandelkow - Journal of Biological Chemistry 1995 cited by 376
- Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration
Authors: Xiaoyu Li, Yatender Kumar, Hans Zempel, Eva‐Maria Mandelkow, Jacek Biernat, Eckhard Mandelkow�, Eckhard Mandelkow�, Eckhard Mandelkow� - The EMBO Journal 2011 cited by 225
- Tau aggregation is driven by a transition from random coil to beta sheet structure
Authors: Martin von Bergen�, Stefan Barghorn, Jacek Biernat, Eva‐Maria Mandelkow, Eckhard Mandelkow� - Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2004 cited by 372
- Amyloid‐β oligomers induce synaptic damage via Tau‐dependent microtubule severing by TTLL6 and spastin
Authors: Hans Zempel, Julia Luedtke, Yatender Kumar, Jacek Biernat, Hana N. Dawson, Eckhard Mandelkow�, Eva‐Maria Mandelkow, Eva‐Maria Mandelkow, Eva‐Maria Mandelkow - The EMBO Journal 2013 cited by 282
- FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease
Authors: Waltraud Mair, Jan Muntel, Katharina Tepper, Shaojun Tang, Jacek Biernat, William W. Seeley, Kenneth S. Kosik, Eckhard Mandelkow�, Hanno Steen, Judith A. Steen - Analytical Chemistry 2016 cited by 154
