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John F.X. Diffley

Active 1986–2025

Also published as
John F. X. Diffley
101
Papers
19,718
Citations
78
h-index
99
i10-index

Citations

Citations per year for John F.X. Diffley1987: 2 citations1988: 6 citations1989: 6 citations1990: 15 citations1991: 16 citations1992: 41 citations1993: 46 citations1994: 51 citations1995: 93 citations1996: 126 citations1997: 159 citations1998: 195 citations1999: 199 citations2000: 286 citations2001: 276 citations2002: 275 citations2003: 236 citations2004: 299 citations2005: 201 citations2006: 186 citations2007: 229 citations2008: 120 citations2009: 183 citations2010: 198 citations2011: 180 citations2012: 144 citations2013: 220 citations2014: 141 citations2015: 126 citations2016: 175 citations2017: 237 citations2018: 156 citations2019: 473 citations2020: 408 citations2021: 477 citations2022: 399 citations2023: 294 citations2024: 437 citations2025: 185 citations2026: 1 citations

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 1,762 citing papers, 37.6% of this breakdownUnited Kingdom: 668 citing papers, 14.3% of this breakdownChina: 232 citing papers, 4.9% of this breakdownJapan: 229 citing papers, 4.9% of this breakdownGermany: 224 citing papers, 4.8% of this breakdownFrance: 212 citing papers, 4.5% of this breakdownCanada: 129 citing papers, 2.8% of this breakdownItaly: 123 citing papers, 2.6% of this breakdownSpain: 112 citing papers, 2.4% of this breakdownSwitzerland: 103 citing papers, 2.2% of this breakdownDenmark: 99 citing papers, 2.1% of this breakdownNetherlands: 76 citing papers, 1.6% of this breakdown
0%37.6%Other 15.3%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology85%
  • Medicine10.9%
  • Agricultural and Biological Sciences1.4%
  • Computer Science0.7%
  • Immunology and Microbiology0.7%
  • Neuroscience0.3%
  • Other1%

Topics

  • DNA Repair Mechanisms21%
  • Genomics and Chromatin Dynamics10%
  • Microtubule and mitosis dynamics7.8%
  • Cancer-related Molecular Pathways4.3%
  • Fungal and yeast genetics research4.2%
  • CRISPR and Genetic Engineering3.5%
  • Other49.2%

Coauthors

All papers

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  1. The Initiation of Eukaryotic DNA Replication

    Authors: Alessandro Costa, John F.X. Diffley - Annual Review of Biochemistry 2022 cited by 246

  2. Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication

    Authors: Jingkun Zeng, Stephanie A. Hills, Eiko Ozono, John F.X. Diffley - Cell 2023 cited by 150

  3. Regulated eukaryotic DNA replication origin firing with purified proteins

    Authors: Joseph T.P. Yeeles, Tom Deegan, Agnieszka Janska, Anne Early, John F.X. Diffley - Nature 2015 cited by 530

  4. How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication

    Authors: Joseph T.P. Yeeles, Agnieska Janska, Anne Early, John F.X. Diffley - Molecular Cell 2016 cited by 380

  5. Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

    Authors: Dirk Remus, Fabienne Beuron, Gökhan Tolun, Jack D. Griffith, Edward P. Morris, John F.X. Diffley - Cell 2009 cited by 697

  6. The mechanism of eukaryotic CMG helicase activation

    Authors: Max E. Douglas, Ferdos Abid Ali, Alessandro Costa, John F.X. Diffley - Nature 2018 cited by 288

  7. Mechanism of replication origin melting nucleated by CMG helicase assembly

    Authors: Jacob S. Lewis, Marta H Gross, Joana S. Sousa, Sarah S. Henrikus, Julia F. Greiwe, Andrea Nans, John F.X. Diffley, Alessandro Costa - Nature 2022 cited by 113

  8. Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM

    Authors: Thomas C. R. Miller, Julia Locke, Julia F. Greiwe, John F.X. Diffley, Alessandro Costa - Nature 2019 cited by 151

  9. ATPase-dependent quality control of DNA replication origin licensing

    Authors: Jordi Frigola, Dirk Remus, Amina Mehanna, John F.X. Diffley - Nature 2013 cited by 234

  10. Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates

    Authors: Christoph F. Kurat, Joseph T.P. Yeeles, Harshil Patel, Anne Early, John F.X. Diffley - Molecular Cell 2016 cited by 259

  11. Positive Supercoiling of Mitotic DNA Drives Decatenation by Topoisomerase II in Eukaryotes

    Authors: Jonathan Baxter, Nicholas Sen, V. López Martínez, M. E. Monturus De Carandini, Jorge B. Schvartzman, John F.X. Diffley, Luís Aragón - Science 2011 cited by 176

  12. Origin Licensing Requires ATP Binding and Hydrolysis by the MCM Replicative Helicase

    Authors: Gideon Coster, Jordi Frigola, Fabienne Beuron, Edward P. Morris, John F.X. Diffley - Molecular Cell 2014 cited by 133

  13. Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading

    Authors: Gideon Coster, John F.X. Diffley - Science 2017 cited by 128

  14. Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation

    Authors: Allison W. McClure, John F.X. Diffley - eLife 2021 cited by 57

  15. Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase

    Authors: Julia F. Greiwe, Thomas C. R. Miller, Julia Locke, Fabrizio Martino, Steven Howell, Anne Schreiber, Andrea Nans, John F.X. Diffley, Alessandro Costa - Nature Structural & Molecular Biology 2021 cited by 50

  16. A replication fork determinant for the establishment of sister chromatid cohesion

    Authors: Masashi Minamino, Céline Bouchoux, Berta Canal, John F.X. Diffley, Frank Uhlmann - Cell 2023 cited by 39

  17. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

    Authors: José Antonio Tercero, John F.X. Diffley - Nature 2001 cited by 671

  18. Mrc1 transduces signals of DNA replication stress to activate Rad53

    Authors: Annette A. Alcasabas, Alexander J. Osborn, Jeff Bachant, Fenghua Hu, Petra Werler, Kristine Bousset, Kanji Furuya, John F.X. Diffley, Antony M. Carr, Stephen J. Elledge - Nature Cell Biology 2001 cited by 528

  19. DNA Replication and Oncogene-Induced Replicative Stress

    Authors: Stephanie A. Hills, John F.X. Diffley - Current Biology 2014 cited by 386

  20. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase

    Authors: Jingkun Zeng, Florian Weissmann, Agustina P. Bertolin, Viktor Posse, Berta Canal, Rachel Ulferts, Mary Wu, Ruth Harvey, Saira Hussain, Jennifer C. Milligan, Chloë Roustan, Annabel Borg, Laura E. McCoy, Lucy S. Drury, Svend Kjær, John W. McCauley, Michael Howell, Rupert Beale, John F.X. Diffley - Biochemical Journal 2021 cited by 78

  21. Cdt1 stabilizes an open MCM ring for helicase loading

    Authors: Jordi Frigola, Jun He, K. Kinkelin, Valerie E. Pye, Ludovic Renault, Max E. Douglas, Dirk Remus, Peter Cherepanov, Alessandro Costa, John F.X. Diffley - Nature Communications 2017 cited by 95

  22. MCM: one ring to rule them all

    Authors: Tom Deegan, John F.X. Diffley - Current Opinion in Structural Biology 2016 cited by 177

  23. Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome

    Authors: Panchali Goswami, Ferdos Abid Ali, Max E. Douglas, Julia Locke, Andrew G. Purkiss, Agnieszka Janska, Patrik Eickhoff, Anne Early, Andrea Nans, Alan C. M. Cheung, John F.X. Diffley, Alessandro Costa - Nature Communications 2018 cited by 129

  24. CDKs Promote DNA Replication Origin Licensing in Human Cells by Protecting Cdc6 from APC/C-Dependent Proteolysis

    Authors: Niels Mailand, John F.X. Diffley - Cell 2005 cited by 340