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K. N. Houk

Active 1970–2025

Also published as
K.N. Houk
362
Papers
63,676
Citations
140
h-index
349
i10-index

Citations

Citations per year for K. N. Houk1958: 1 citations1974: 2 citations1975: 4 citations1976: 6 citations1977: 3 citations1978: 5 citations1979: 5 citations1980: 12 citations1982: 5 citations1983: 14 citations1984: 15 citations1985: 10 citations1986: 16 citations1987: 13 citations1988: 15 citations1989: 14 citations1990: 21 citations1991: 25 citations1992: 17 citations1993: 24 citations1994: 19 citations1995: 27 citations1996: 67 citations1997: 56 citations1998: 62 citations1999: 58 citations2000: 68 citations2001: 65 citations2002: 85 citations2003: 127 citations2004: 147 citations2005: 173 citations2006: 213 citations2007: 198 citations2008: 268 citations2009: 292 citations2010: 306 citations2011: 403 citations2012: 373 citations2013: 344 citations2014: 400 citations2015: 374 citations2016: 285 citations2017: 373 citations2018: 343 citations2019: 864 citations2020: 992 citations2021: 1,076 citations2022: 976 citations2023: 741 citations2024: 1,336 citations2025: 802 citations2026: 30 citations1959–1973: no citations, so these years are not shown1981: no citations, so this year is not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 3,024 citing papers, 26.7% of this breakdownChina: 2,079 citing papers, 18.4% of this breakdownGermany: 810 citing papers, 7.2% of this breakdownUnited Kingdom: 625 citing papers, 5.5% of this breakdownJapan: 485 citing papers, 4.3% of this breakdownSpain: 343 citing papers, 3% of this breakdownSwitzerland: 314 citing papers, 2.8% of this breakdownFrance: 314 citing papers, 2.8% of this breakdownCanada: 284 citing papers, 2.5% of this breakdownIndia: 257 citing papers, 2.3% of this breakdownItaly: 224 citing papers, 2% of this breakdownNetherlands: 185 citing papers, 1.6% of this breakdown
0%26.7%Other 20.9%

Institutions

Fields

  • Chemistry31.4%
  • Biochemistry, Genetics and Molecular Biology29.2%
  • Medicine11.6%
  • Pharmacology, Toxicology and Pharmaceutics6.4%
  • Materials Science6.2%
  • Engineering4.7%
  • Other10.5%

Topics

  • Chemical Synthesis and Analysis5.5%
  • Protein Structure and Dynamics3.4%
  • Click Chemistry and Applications2.8%
  • Enzyme Catalysis and Immobilization2.6%
  • Fluorine in Organic Chemistry2.5%
  • Microbial Natural Products and Biosynthesis2.4%
  • Other80.8%

Coauthors

All papers

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  1. De novo design of luciferases using deep learning

    Authors: Hsien‐Wei Yeh, Christoffer Norn, Yakov Kipnis, Doug Tischer, Samuel J. Pellock, Declan Evans, Pengchen Ma, Gyu Rie Lee, Jason Z. Zhang, Ivan Anishchenko, Brian Coventry, Longxing Cao, Justas Dauparas, Samer Halabiya, Michelle DeWitt, Lauren Carter, K. N. Houk, David Baker - Nature 2023 cited by 451

  2. Characterization and heterologous reconstitution of Taxus biosynthetic enzymes leading to baccatin III

    Authors: Bin Jiang, Lei Gao, Haijun Wang, Haijun Wang, Ya‐Ping Sun, Xiaolin Zhang, Ke Han, Shengchao Liu, Pengchen Ma, Qinggang Liao, Yue Wang, Huan Wang, Huan Wang, Yugeng Liu, Ran Du, Torben Rogge, Wei Li, Yi Shang, K. N. Houk, Xingyao Xiong, Daoxin Xie, Sanwen Huang, Xiaoguang Lei, Jianbin Yan - Science 2024 cited by 190

  3. Computational Redesign of a PETase for Plastic Biodegradation under Ambient Condition by the GRAPE Strategy

    Authors: Yinglu Cui, Yanchun Chen, Xinyue Liu, Saijun Dong, Yue Tian, Yuxin Qiao, Ruchira Mitra, Jing Han, Chunli Li, Xu Han, Weidong Liu, Quan Chen, Wangqing Wei, Xin Wang, Wenbin Du, Shuang‐Yan Tang, Hua Xiang, Haiyan Liu, Yong Liang, K. N. Houk, Bian Wu - ACS Catalysis 2021 cited by 584

  4. Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

    Authors: Justin B. Siegel, Alexandre Zanghellini, Helena M. Lovick, Gert Kiss, Abigail R. Lambert, Jennifer L. St.Clair, Jasmine L. Gallaher, Donald Hilvert, Michael H. Gelb, Barry Stoddard, K. N. Houk, Forrest E. Michael, David Baker - Science 2010 cited by 935

  5. Sequential C–F bond functionalizations of trifluoroacetamides and acetates via spin-center shifts

    Authors: You‐Jie Yu, Feng‐Lian Zhang, Tianyu Peng, Chang-Ling Wang, Jie Cheng, Chen Chen, K. N. Houk, Yi‐Feng Wang - Science 2021 cited by 311

  6. Kemp elimination catalysts by computational enzyme design

    Authors: Daniela Röthlisberger, Olga Khersonsky, Andrew M. Wollacott, Lin Jiang, Jason DeChancie, Jamie L. Betker, Jasmine L. Gallaher, Eric A. Althoff, Alexandre Zanghellini, Orly Dym, Shira Albeck, K. N. Houk, Dan S. Tawfik, David Baker - Nature 2008 cited by 1,332

  7. Analyzing Reaction Rates with the Distortion/Interaction‐Activation Strain Model

    Authors: F. Matthias Bickelhaupt, K. N. Houk - Angewandte Chemie International Edition 2017 cited by 1,671

  8. De Novo Computational Design of Retro-Aldol Enzymes

    Authors: Lin Jiang, Eric A. Althoff, Fernando R. Clemente, Lindsey Doyle, Daniela Röthlisberger, Alexandre Zanghellini, Jasmine L. Gallaher, Jamie L. Betker, Fujie Tanaka, Carlos F. Barbas, Donald Hilvert, K. N. Houk, Barry Stoddard, David Baker - Science 2008 cited by 1,194

  9. Computational design of serine hydrolases

    Authors: Anna Lauko, Samuel J. Pellock, Kiera H. Sumida, Ivan Anishchenko, David Juergens, Woody Ahern, Ji-Ung Jeung, Alex Shida, Andrew C. Hunt, Indrek Kalvet, Christoffer Norn, Ian R. Humphreys, Cooper S. Jamieson, Rohith Krishna, Yakov Kipnis, Alex Kang, Evans Brackenbrough, Asim K. Bera, Banumathi Sankaran, K. N. Houk, David Baker - Science 2025 cited by 178

  10. Dearomative ring expansion of thiophenes by bicyclobutane insertion

    Authors: Huamin Wang, Huiling Shao, Ankita Das, Subhabrata Dutta, Hok Tsun Chan, Constantin G. Daniliuc, K. N. Houk, Frank Glorius - Science 2023 cited by 212

  11. Benchmarking the Conductor-like Polarizable Continuum Model (CPCM) for Aqueous Solvation Free Energies of Neutral and Ionic Organic Molecules

    Authors: Yu Takano, K. N. Houk - Journal of Chemical Theory and Computation 2004 cited by 1,257

  12. ortho-Selective Dearomative [2π + 2σ] Photocycloadditions of Bicyclic Aza-Arenes

    Authors: Roman Kleinmans, Subhabrata Dutta, Kristers Ozols, Huiling Shao, Felix Schäfer, Rebecca E. Thielemann, Hok Tsun Chan, Constantin G. Daniliuc, K. N. Houk, Frank Glorius - Journal of the American Chemical Society 2023 cited by 207

  13. A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion

    Authors: S.J.B. Mallinson, Melodie M. Machovina, Rodrigo L. Silveira, Marc Garcia‐Borràs, Nathan M. Gallup, Christopher W. Johnson, Mark D. Allen, Munir S. Skaf, Michael F. Crowley, Ellen L. Neidle, K. N. Houk, Gregg T. Beckham, Jennifer L. DuBois, J.E. McGeehan - Nature Communications 2018 cited by 231

  14. Computational Enzyme Design

    Authors: Gert Kiss, Nihan Çelebi‐Ölçüm, Rocco Moretti, David Baker, K. N. Houk - Angewandte Chemie International Edition 2013 cited by 496

  15. Controllable catalytic difluorocarbene transfer enables access to diversified fluoroalkylated arenes

    Authors: Xia‐Ping Fu, Xiao‐Song Xue, Xueying Zhang, Yu‐Lan Xiao, Shu Zhang, Yinlong Guo, Xuebing Leng, K. N. Houk, Xingang Zhang, Xingang Zhang, Xingang Zhang - Nature Chemistry 2019 cited by 215

  16. Uncovering the Key Role of Distortion in Bioorthogonal Tetrazine Tools That Defy the Reactivity/Stability Trade-Off

    Authors: Dennis Svatunek, Martin Wilkovitsch, Lea Hartmann, K. N. Houk, Hannes Mikula - Journal of the American Chemical Society 2022 cited by 103

  17. Low-temperature mineralization of perfluorocarboxylic acids

    Authors: Brittany Trang, Yuli Li, Xiao‐Song Xue, Mohamed Ateia, K. N. Houk, William R. Dichtel - Science 2022 cited by 382

  18. FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis

    Authors: Lei Gao, Cong Su, Xiaoxia Du, Ruishan Wang, Shuming Chen, Yu Zhou, Chengwei Liu, Xiaojing Liu, Runze Tian, Liyun Zhang, Kebo Xie, She Chen, Qianqian Guo, Lanping Guo, Yoshio Hano, Manabu Shimazaki, Atsushi Minami, Hideaki Oikawa, Niu Huang, K. N. Houk, Luqi Huang, Jungui Dai, Xiaoguang Lei - Nature Chemistry 2020 cited by 162

  19. Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold

    Authors: Sophie Basler, Sabine Studer, Yike Zou, Takahiro Mori, Yusuke Ota, Anna Camus, H. Adrian Bunzel, Roger C. Helgeson, K. N. Houk, Gonzalo Jiménez‐Osés, Donald Hilvert - Nature Chemistry 2021 cited by 105

  20. Iterative approach to computational enzyme design

    Authors: Heidi K. Privett, Gert Kiss, Toni M. Lee, Rebecca Blomberg, Roberto A. Chica, Leonard M. Thomas, Donald Hilvert, K. N. Houk, Stephen L. Mayo - National Academy of Sciences, Proceedings of the National Academy of Sciences 2012 cited by 338

  21. The role of distant mutations and allosteric regulation on LovD active site dynamics

    Authors: Gonzalo Jiménez‐Osés, Sílvia Osuna, Xue Gao, M.R. Sawaya, Lynne Gilson, Steven J. Collier, Gjalt W. Huisman, Todd O. Yeates, Yi Tang, K. N. Houk - Nature Chemical Biology 2014 cited by 218

  22. Computational Design of Enone-Binding Proteins with Catalytic Activity for the Morita–Baylis–Hillman Reaction

    Authors: Sinisa Bjelic, Lucas G. Nivón, Nihan Çelebi‐Ölçüm, Gert Kiss, Carolyn F. Rosewall, Helena M. Lovick, Erica L. Ingalls, Jasmine L. Gallaher, J. Seetharaman, Scott Lew, G.T. Montelione, J.F. Hunt, Forrest E. Michael, K. N. Houk, David Baker - ACS Chemical Biology 2013 cited by 105

  23. Cooperative Stapling of Native Peptides at Lysine and Tyrosine or Arginine with Formaldehyde

    Authors: Bo Li, Hong Tang, Aneta Turlik, Zhao Wan, Xiao‐Song Xue, Li Li, Xiaoxiao Yang, Jiuyuan Li, Gang He, K. N. Houk, Gong Chen - Angewandte Chemie International Edition 2020 cited by 72

  24. Spirostrain-Accelerated Chemiexcitation of Dioxetanes Yields Unprecedented Detection Sensitivity in Chemiluminescence Bioassays

    Authors: Rozan Tannous, Omri Shelef, Sara Gutkin, Maya David, Thomas Leirikh, Liang Ge, Qais Z. Jaber, Qingyang Zhou, Pengchen Ma, Micha Fridman, Urs Spitz, K. N. Houk, Doron Shabat - ACS Central Science 2023 cited by 58