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Leo E. Otterbein

Active 1995–2025

115
Papers
24,061
Citations
83
h-index
113
i10-index

Citations

Citations per year for Leo E. Otterbein1971: 1 citations1987: 1 citations1996: 6 citations1997: 12 citations1998: 22 citations1999: 39 citations2000: 82 citations2001: 90 citations2002: 225 citations2003: 260 citations2004: 348 citations2005: 351 citations2006: 505 citations2007: 323 citations2008: 273 citations2009: 293 citations2010: 272 citations2011: 211 citations2012: 225 citations2013: 223 citations2014: 193 citations2015: 278 citations2016: 242 citations2017: 273 citations2018: 210 citations2019: 709 citations2020: 822 citations2021: 747 citations2022: 622 citations2023: 472 citations2024: 564 citations2025: 256 citations2026: 1 citations1972–1986: no citations, so these years are not shown1988–1995: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 1,967 citing papers, 28% of this breakdownChina: 1,228 citing papers, 17.5% of this breakdownUnited Kingdom: 364 citing papers, 5.2% of this breakdownGermany: 358 citing papers, 5.1% of this breakdownItaly: 298 citing papers, 4.2% of this breakdownJapan: 263 citing papers, 3.7% of this breakdownSouth Korea: 229 citing papers, 3.3% of this breakdownCanada: 182 citing papers, 2.6% of this breakdownFrance: 176 citing papers, 2.5% of this breakdownAustralia: 165 citing papers, 2.3% of this breakdownIndia: 115 citing papers, 1.6% of this breakdownNetherlands: 113 citing papers, 1.6% of this breakdown
0%28%Other 22.4%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology52.3%
  • Medicine25.7%
  • Immunology and Microbiology9.9%
  • Engineering3%
  • Neuroscience2.8%
  • Chemistry1.8%
  • Other4.5%

Topics

  • Heme Oxygenase-1 and Carbon Monoxide12.9%
  • Neonatal Health and Biochemistry4.1%
  • Hemoglobin structure and function3.4%
  • Immune cells in cancer2.6%
  • Nanoplatforms for cancer theranostics1.7%
  • Cannabis and Cannabinoid Research1.5%
  • Other73.8%

Coauthors

All papers

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  1. The therapeutic potential of carbon monoxide

    Authors: Roberto Motterlini, Leo E. Otterbein - Nature Reviews Drug Discovery 2010 cited by 1,612

  2. The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

    Authors: Arvand Haschemi, Paul Kosma, Lars Gille, Charles R. Evans, Charles Burant, Philipp Starkl, Bernhard Knapp, Robert Haas, Johannes A. Schmid, Christoph Jandl, Shahzada Amir, Gert Lübec, Jaehong Park, Harald Esterbauer, Martin Bilban, Leonardo Brizuela, J. Andrew Pospisilik, Leo E. Otterbein, Oswald Wagner - Cell Metabolism 2012 cited by 631

  3. Enrichment-triggered prodrug activation demonstrated through mitochondria-targeted delivery of doxorubicin and carbon monoxide

    Authors: Yueqin Zheng, Xingyue Ji, Bingchen Yu, Kaili Ji, David Gallo, Eva Csizmadia, Mengyuan Zhu, Manjusha Roy Choudhury, Ladie Kimberly C. De La Cruz, Vayou Chittavong, Zhixiang Pan, Zhengnan Yuan, Leo E. Otterbein, Binghe Wang - Nature Chemistry 2018 cited by 313

  4. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

    Authors: Leo E. Otterbein, Fritz H. Bach, Jawed Alam, Miguel P. Soares, Hong Lu, Mark Wysk, Roger J. Davis, Richard A. Flavell, Augustine M.K. Choi - Nature Medicine 2000 cited by 2,140

  5. Caveolin-1 selectively regulates microRNA sorting into microvesicles after noxious stimuli

    Authors: Heedoo Lee, Chunhua Li, Yang Zhang, Duo Zhang, Leo E. Otterbein, Yang Jin - The Journal of Experimental Medicine 2019 cited by 216

  6. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

    Authors: Iván Mascanfroni, Maisa C. Takenaka, Ada Yeste, Bonny Patel, Yan Wu, Jessica E. Kenison, Shafiuddin Siddiqui, Alexandre S. Basso, Leo E. Otterbein, Drew M. Pardoll, Fan Pan, Avner Priel, Clary B. Clish, Simon C. Robson, Francisco J. Quintana - Nature Medicine 2015 cited by 446

  7. Carbon Monoxide Expedites Metabolic Exhaustion to Inhibit Tumor Growth

    Authors: Barbara Wegiel, David Gallo, Eva Csizmadia, Clair Harris, John D. Belcher, Gregory M. Vercellotti, Nuno Penacho, Pankaj Seth, Vikas P. Sukhatme, Asif Ahmed, Pier Paolo Pandolfi, Leszek Helczynski, Anders Bjartell, Jenny L. Persson, Leo E. Otterbein - Cancer Research 2013 cited by 373

  8. Heme oxygenase-1: unleashing the protective properties of heme

    Authors: Leo E. Otterbein, Miguel P. Soares, Kenichiro Yamashita, Fritz H. Bach - Trends in Immunology 2003 cited by 1,162

  9. Delivery of therapeutic carbon monoxide by gas-entrapping materials

    Authors: James D. Byrne, David Gallo, Hannah Boyce, Sarah Becker, Kristi M. Kezar, Alicia T. Cotoia, Vivian R. Feig, Aaron Lopes, Eva Csizmadia, Maria Serena Longhi, Jung Seung Lee, Hyunjoon Kim, Adam Wentworth, Sidharth Shankar, Ghee Rye Lee, Jianling Bi, Emily Witt, Keiko Ishida, Alison Hayward, Johannes Kuosmanen, J. A. Jenkins, Jacob Wainer, Aya Aragon, Kaitlyn Wong, Christoph Steiger, William R. Jeck, Dustin E. Bosch, Mitchell C. Coleman, Douglas R. Spitz, Michael S. Tift, Róbert Langer, Leo E. Otterbein, Giovanni Traverso - Science Translational Medicine 2022 cited by 82

  10. Heme Oxygenase-1 and Carbon Monoxide in the Heart

    Authors: Leo E. Otterbein, Roberta Foresti, Roberto Motterlini - Circulation Research 2016 cited by 220

  11. Mitochondrial DNA Released by Trauma Induces Neutrophil Extracellular Traps

    Authors: Kiyoshi Itagaki, Elżbieta Kaczmarek, Yen Ting Lee, I. Tien Tang, Burak Isal, Yashar Adibnia, Nicola Sandler, Melissa Grimm, Brahm H. Segal, Leo E. Otterbein, Carl J. Hauser - PLoS ONE 2015 cited by 192

  12. Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1

    Authors: Nils Schallner, Rambhau Pandit, Robert H. LeBlanc, Ajith J. Thomas, Christopher S. Ogilvy, Brian S. Zuckerbraun, David Gallo, Leo E. Otterbein, Khalid A. Hanafy - Journal of Clinical Investigation 2015 cited by 220

  13. Mitochondrial DAMPs Increase Endothelial Permeability through Neutrophil Dependent and Independent Pathways

    Authors: Shiqin Sun, Tolga Sursal, Yasaman Adibnia, Cong Zhao, Yi Zheng, Haipeng Li, Leo E. Otterbein, Carl J. Hauser, Kiyoshi Itagaki - PLoS ONE 2013 cited by 213

  14. Macrophages sense and kill bacteria through carbon monoxide–dependent inflammasome activation

    Authors: Barbara Wegiel, Rasmus Larsen, David Gallo, Beek Yoke Chin, Clair Harris, Praveen Mannam, Elżbieta Kaczmarek, Patty J. Lee, Brian S. Zuckerbraun, Richard A. Flavell, Miguel P. Soares, Leo E. Otterbein - Journal of Clinical Investigation 2014 cited by 181

  15. Carbon Monoxide: from Poison to Clinical Trials

    Authors: Rosalba Siracusa, Alexa Schaufler, Vittorio Calabrese, Patrick M. Fuller, Leo E. Otterbein - Trends in Pharmacological Sciences 2021 cited by 92

  16. Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis

    Authors: Sophie Brouard, Leo E. Otterbein, Josef Anrather, Edda Tobiasch, Fritz H. Bach, Augustine M.K. Choi, Miguel P. Soares - The Journal of Experimental Medicine 2000 cited by 983

  17. Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species

    Authors: Brian S. Zuckerbraun, Beek Yoke Chin, Martin Bilban, Joana C. d’Avila, Jayashree Rao, Timothy R. Billiar, Leo E. Otterbein - The FASEB Journal 2007 cited by 319

  18. Hypoxia-inducible factor 1α stabilization by carbon monoxide results in cytoprotective preconditioning

    Authors: Beek Yoke Chin, Ge Jiang, Barbara Wegiel, Hong J. Wang, Theresa Y. MacDonald, Xuchen Zhang, David Gallo, Eva Cszimadia, Fritz H. Bach, Patty J. Lee, Leo E. Otterbein - National Academy of Sciences, Proceedings of the National Academy of Sciences 2007 cited by 223

  19. Toward Carbon Monoxide–Based Therapeutics: Critical Drug Delivery and Developability Issues

    Authors: Xingyue Ji, Krishna Damera, Yueqin Zheng, Bingchen Yu, Leo E. Otterbein, Binghe Wang - Journal of Pharmaceutical Sciences 2016 cited by 171

  20. Mitochondrial DAMPs Are Released During Cardiopulmonary Bypass Surgery and Are Associated With Postoperative Atrial Fibrillation

    Authors: Nicola Sandler, Elżbieta Kaczmarek, Kiyoshi Itagaki, Yi Zheng, Leo E. Otterbein, Kamal R. Khabbaz, David Liu, Venkatachalam Senthilnathan, Russell L. Gruen, Carl J. Hauser - Heart Lung and Circulation 2017 cited by 92

  21. NO, CO and H2S: A trinacrium of bioactive gases in the brain

    Authors: Rosalba Siracusa, Vanessa Azevedo Voltarelli, Angela Trovato Salinaro, Sergio Modafferi, Salvatore Cuzzocrea, Edward J. Calabrese, Rosanna Di Paola, Leo E. Otterbein, Vittorio Calabrese - Biochemical Pharmacology 2022 cited by 54

  22. Trauma-induced heme release increases susceptibility to bacterial infection

    Authors: Ghee Rye Lee, David Gallo, Rodrigo Wagner Alves de Souza, Shilpa Tiwari‐Heckler, Eva Csizmadia, James Harbison, Sidharth Shankar, Valerie Banner‐Goodspeed, Michael B. Yaffe, Maria Serena Longhi, Carl J. Hauser, Leo E. Otterbein - JCI Insight 2021 cited by 29

  23. Go Green: The Anti-Inflammatory Effects of Biliverdin Reductase

    Authors: Barbara Wegiel, Leo E. Otterbein - Frontiers in Pharmacology 2012 cited by 137

  24. Carbon monoxide and a change of heart

    Authors: Louis M. Chu, Shazhad Shaefi, James D. Byrne, Rodrigo Wagner Alves de Souza, Leo E. Otterbein - Redox Biology 2021 cited by 45