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Leonard D. Shultz

Active 1975–2024

181
Papers
37,220
Citations
108
h-index
180
i10-index

Citations

Citations per year for Leonard D. Shultz1943: 1 citations1980: 1 citations1981: 2 citations1984: 4 citations1985: 11 citations1986: 14 citations1987: 9 citations1988: 12 citations1989: 16 citations1990: 15 citations1991: 19 citations1992: 24 citations1993: 53 citations1994: 28 citations1995: 59 citations1996: 78 citations1997: 111 citations1998: 197 citations1999: 201 citations2000: 239 citations2001: 227 citations2002: 245 citations2003: 260 citations2004: 180 citations2005: 222 citations2006: 223 citations2007: 232 citations2008: 287 citations2009: 281 citations2010: 333 citations2011: 341 citations2012: 370 citations2013: 367 citations2014: 315 citations2015: 321 citations2016: 324 citations2017: 358 citations2018: 373 citations2019: 1,073 citations2020: 1,158 citations2021: 1,125 citations2022: 753 citations2023: 635 citations2024: 1,017 citations2025: 574 citations2026: 12 citations1944–1979: no citations, so these years are not shown1982–1983: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 4,873 citing papers, 33.7% of this breakdownChina: 1,262 citing papers, 8.7% of this breakdownUnited Kingdom: 918 citing papers, 6.3% of this breakdownGermany: 881 citing papers, 6.1% of this breakdownJapan: 648 citing papers, 4.5% of this breakdownCanada: 560 citing papers, 3.9% of this breakdownFrance: 514 citing papers, 3.6% of this breakdownItaly: 480 citing papers, 3.3% of this breakdownAustralia: 461 citing papers, 3.2% of this breakdownSwitzerland: 390 citing papers, 2.7% of this breakdownNetherlands: 347 citing papers, 2.4% of this breakdownSpain: 304 citing papers, 2.1% of this breakdown
0%33.7%Other 19.5%

Institutions

Fields

  • Medicine45.2%
  • Biochemistry, Genetics and Molecular Biology31.7%
  • Immunology and Microbiology17.6%
  • Neuroscience2.4%
  • Engineering1.1%
  • Agricultural and Biological Sciences0.6%
  • Other1.4%

Topics

  • Immune Cell Function and Interaction4.7%
  • T-cell and B-cell Immunology3.5%
  • Immunotherapy and Immune Responses3.2%
  • Immune cells in cancer2.6%
  • Cancer Cells and Metastasis2.5%
  • CAR-T cell therapy research2.2%
  • Other81.3%

Coauthors

All papers

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  1. Humanized mouse models for immuno-oncology research

    Authors: Jane Chuprin, Hannah Buettner, Mina O. Seedhom, Dale L. Greiner, James Keck, Fumihiko Ishikawa, Leonard D. Shultz, Michael A. Brehm - Nature Reviews Clinical Oncology 2023 cited by 360

  2. Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis

    Authors: Peishan Li, Ming Lü, Jiayuan Shi, Zheng Gong, Li Hua, Qing Li, Bora Lim, Xiang H.-F. Zhang, Xiaowen Chen, Sheng Li, Leonard D. Shultz, Guangwen Ren - Nature Immunology 2020 cited by 242

  3. Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment

    Authors: Zheng Gong, Qing Li, Jiayuan Shi, Jian Wei, Peishan Li, Chih‐Hao Chang, Leonard D. Shultz, Guangwen Ren - Immunity 2022 cited by 244

  4. Human Lymphoid and Myeloid Cell Development in NOD/LtSz- scid IL2R γ null Mice Engrafted with Mobilized Human Hemopoietic Stem Cells,

    Authors: Leonard D. Shultz, Bonnie Lyons, Lisa Burzenski, Bruce Gott, Xiaohua Chen, Stanley Chaleff, Malak Kotb, Stephen D. Gillies, Marie King, Julie Mangada, Dale L. Greiner, Rupert Handgretinger - The Journal of Immunology 2005 cited by 1,715

  5. Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells

    Authors: Zheng Gong, Qing Li, Jiayuan Shi, Edison T. Liu, Leonard D. Shultz, Guangwen Ren - Cell Metabolism 2022 cited by 121

  6. Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis

    Authors: Zheng Gong, Qing Li, Jiayuan Shi, Peishan Li, Li Hua, Leonard D. Shultz, Guangwen Ren - Science Immunology 2023 cited by 118

  7. Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status

    Authors: Peishan Li, Ming Lü, Jiayuan Shi, Li Hua, Zheng Gong, Qing Li, Leonard D. Shultz, Guangwen Ren - Nature Communications 2020 cited by 157

  8. Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain

    Authors: Devon S. Svoboda, M. Inmaculada Barrasa, Jian Shu, Rosalie Rietjens, Shupei Zhang, Maya Mitalipova, Peter Berube, Dongdong Fu, Leonard D. Shultz, George W. Bell, Rudolf Jaenisch - National Academy of Sciences, Proceedings of the National Academy of Sciences 2019 cited by 222

  9. Humanized mice for immune system investigation: progress, promise and challenges

    Authors: Leonard D. Shultz, Michael A. Brehm, J. Víctor García, Dale L. Greiner - Nature reviews. Immunology 2012 cited by 963

  10. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region

    Authors: Fumihiko Ishikawa, Shuro Yoshida, Yoriko Saito, Atsushi Hijikata, Hiroshi Kitamura, Satoshi Tanaka, Ryu Nakamura, Toru Tanaka, Hiroko Tomiyama, Noriyuki Saito, Mitsuhiro Fukata, Toshihiro Miyamoto, Bonnie Lyons, Koichi Ohshima, Naoyuki Uchida, Shuichi Taniguchi, Osamu Ohara, Koichi Akashi, Mine Harada, Leonard D. Shultz - Nature Biotechnology 2007 cited by 975

  11. Humanized immune system mouse models: progress, challenges and opportunities

    Authors: Todd M. Allen, Michael A. Brehm, Sandra H. Bridges, S E Ferguson, Priti Kumar, Oleg Mirochnitchenko, Karolina Palucka, Roberta Pelanda, Brigitte E. Sanders-Beer, Leonard D. Shultz, Lishan Su, Mercy PrabhuDas - Nature Immunology 2019 cited by 249

  12. Humanized mice in translational biomedical research

    Authors: Leonard D. Shultz, Fumihiko Ishikawa, Dale L. Greiner - Nature reviews. Immunology 2007 cited by 1,259

  13. Humanized Mouse Models of Clinical Disease

    Authors: Nicole C. Walsh, Laurie L. Kenney, Sonal Jangalwe, Ken‐Edwin Aryee, Dale L. Greiner, Michael A. Brehm, Leonard D. Shultz - Annual Review of Pathology Mechanisms of Disease 2016 cited by 555

  14. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chainnull mice

    Authors: Fumihiko Ishikawa, Masaki Yasukawa, Bonnie Lyons, Shuro Yoshida, Toshihiro Miyamoto, Goichi Yoshimoto, Takeshi Watanabe, Koichi Akashi, Leonard D. Shultz, Mine Harada - Blood 2005 cited by 920

  15. Lack of acute xenogeneic graft‐ versus ‐host disease, but retention of T‐cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression

    Authors: Michael A. Brehm, Laurie L. Kenney, Michael V. Wiles, Benjamin E. Low, Roland Tisch, Lisa Burzenski, Christian Mueller, Dale L. Greiner, Leonard D. Shultz - The FASEB Journal 2018 cited by 182

  16. Multiple defects in innate and adaptive immunologic function in NOD/LtSz- scid mice.

    Authors: Leonard D. Shultz, Peter A. Schweitzer, Sherri W. Christianson, Bruce Gott, Isabelle B. Schweitzer, Barbara J. Tennent, Sarah McKenna, L E Mobraaten, T. V. Rajan, Dale L. Greiner, E H Leiter - The Journal of Immunology 1995 cited by 1,227

  17. Humanized mice in studying efficacy and mechanisms of PD‐1‐targeted cancer immunotherapy

    Authors: Minan Wang, Li‐Chin Yao, Mingshan Cheng, Danying Cai, Jan Martínek, Chong-xian Pan, Wei Shi, Ai‐Hong Ma, Ralph W. de Vere White, Susan Airhart, Edison T. Liu, Jacques Banchereau, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Karolina Palucka, James Keck - The FASEB Journal 2017 cited by 354

  18. Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

    Authors: Michelle A. King, Laurence Covassin, Michael A. Brehm, Waldemar J. Racki, Todd Pearson, Jean Leif, Joseph Laning, William L. Fodor, Oded Foreman, Lisa Burzenski, Thomas H. Chase, Bruce Gott, Aldo A. Rossini, Rita Bortell, Leonard D. Shultz, Dale L. Greiner - Clinical & Experimental Immunology 2009 cited by 376

  19. Genetic risk converges on regulatory networks mediating early type 2 diabetes

    Authors: John T. Walker, Diane C. Saunders, Vivek Rai, Hung‐Hsin Chen, Peter Orchard, Chunhua Dai, Yasminye D. Pettway, Alexander L. Hopkirk, Conrad Reihsmann, Yicheng Tao, Simin Fan, Shristi Shrestha, Arushi Varshney, Lauren E. Petty, J. J. Wright, Christa Ventresca, Samir Agarwala, Radhika Aramandla, Greg Poffenberger, Regina Jenkins, Shaojun Mei, Nathaniel Hart, Sharon Phillips, Hakmook Kang, Dale L. Greiner, Leonard D. Shultz, Rita Bottino, Jie Liu, Jennifer E. Below, Stephen C.J. Parker, Alvin C. Powers, Marcela Briššová - Nature 2023 cited by 71

  20. Mesenchymal stem cells: From regeneration to cancer

    Authors: Peishan Li, Zheng Gong, Leonard D. Shultz, Guangwen Ren - Pharmacology & Therapeutics 2019 cited by 142

  21. Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma

    Authors: Ramona Crescenzo, Francesco Abate, Elena Lasorsa, Fabrizio Tabbò, Marcello Gaudiano, Nicoletta Chiesa, Filomena Di Giacomo, Elisa Spaccarotella, Luigi Barbarossa, Elisabetta Ercole, Maria Chiara Todaro, Michela Boi, Andrea Acquaviva, Elisa Ficarra, Domenico Novero, Andrea Rinaldi, Thomas Tousseyn, Andreas Rosenwald, Lukas Kenner, Lorenzo Cerroni, Alexandar Tzankov, Maurilio Ponzoni, Marco Paulli, Dennis D. Weisenburger, Wing C. Chan, Javeed Iqbal, Miguel Á. Piris, Alberto Zamò, Carmela Ciardullo, Davide Rossi, Gianluca Gaïdano, Stefano Pileri, Enrico Tiacci, Brunangelo Falini, Leonard D. Shultz, Laurence Mévellec, Jorge Vialard, Roberto Piva, Francesco Bertoni, Raúl Rabadán, Giorgio Inghirami - Cancer Cell 2015 cited by 442

  22. α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes

    Authors: Marcela Briššová, Rachana Haliyur, Diane C. Saunders, Shristi Shrestha, Chunhua Dai, David M. Blodgett, Rita Bottino, Martha Campbell‐Thompson, Radhika Aramandla, Gregory Poffenberger, J Lindner, Fong Cheng Pan, Matthias G. von Herrath, Dale L. Greiner, Leonard D. Shultz, May Sanyoura, Louis H. Philipson, Mark A. Atkinson, David M. Harlan, Shawn Levy, Nripesh Prasad, Roland Stein, Alvin C. Powers - Cell Reports 2018 cited by 219

  23. Identification of Therapeutic Targets for Quiescent, Chemotherapy-Resistant Human Leukemia Stem Cells

    Authors: Yoriko Saito, Hiroshi Kitamura, Atsushi Hijikata, Mariko Tomizawa-Murasawa, Satoshi Tanaka, Shinsuke Takagi, Naoyuki Uchida, Nahoko Suzuki, Akiko Sone, Yuho Najima, Hidetoshi Ozawa, Atsushi Wake, Shuichi Taniguchi, Leonard D. Shultz, Osamu Ohara, Fumihiko Ishikawa - Science Translational Medicine 2010 cited by 458

  24. Enhanced development of functional human NK cells in NOD‐ scid‐IL2rg null mice expressing human IL15

    Authors: Ken‐Edwin Aryee, Lisa Burzenski, Li‐Chin Yao, James Keck, Dale L. Greiner, Leonard D. Shultz, Michael A. Brehm - The FASEB Journal 2022 cited by 53