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Manfred T. Reetz

Active 1972–2025

184
Papers
35,626
Citations
116
h-index
183
i10-index

Citations

Citations per year for Manfred T. Reetz1972: 2 citations1974: 1 citations1982: 1 citations1983: 4 citations1984: 15 citations1985: 9 citations1986: 2 citations1987: 17 citations1988: 15 citations1989: 3 citations1990: 14 citations1991: 23 citations1992: 4 citations1993: 7 citations1994: 16 citations1995: 6 citations1996: 36 citations1997: 46 citations1998: 65 citations1999: 114 citations2000: 128 citations2001: 204 citations2002: 198 citations2003: 244 citations2004: 294 citations2005: 311 citations2006: 300 citations2007: 266 citations2008: 310 citations2009: 242 citations2010: 370 citations2011: 312 citations2012: 240 citations2013: 229 citations2014: 211 citations2015: 198 citations2016: 191 citations2017: 236 citations2018: 220 citations2019: 699 citations2020: 660 citations2021: 663 citations2022: 548 citations2023: 373 citations2024: 655 citations2025: 249 citations2026: 4 citations1973: no citations, so this year is not shown1975–1981: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorChina: 1,005 citing papers, 17.1% of this breakdownUnited States: 962 citing papers, 16.3% of this breakdownGermany: 709 citing papers, 12% of this breakdownUnited Kingdom: 322 citing papers, 5.5% of this breakdownNetherlands: 277 citing papers, 4.7% of this breakdownSpain: 271 citing papers, 4.6% of this breakdownIndia: 201 citing papers, 3.4% of this breakdownFrance: 191 citing papers, 3.2% of this breakdownSwitzerland: 183 citing papers, 3.1% of this breakdownJapan: 182 citing papers, 3.1% of this breakdownCanada: 123 citing papers, 2.1% of this breakdownSouth Korea: 120 citing papers, 2% of this breakdown
0%17.1%Other 22.9%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology50.8%
  • Chemistry23.8%
  • Materials Science8.4%
  • Medicine3.7%
  • Pharmacology, Toxicology and Pharmaceutics3.5%
  • Engineering3.4%
  • Other6.4%

Topics

  • Enzyme Catalysis and Immobilization13.9%
  • Microbial Metabolic Engineering and Bioproduction7.5%
  • Chemical Synthesis and Analysis4.6%
  • Asymmetric Hydrogenation and Catalysis3.4%
  • Protein Structure and Dynamics2.2%
  • Pharmacogenetics and Drug Metabolism2%
  • Other66.4%

Coauthors

All papers

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  1. The Crucial Role of Methodology Development in Directed Evolution of Selective Enzymes

    Authors: Ge Qu, Aitao Li, Carlos G. Acevedo‐Rocha, Zhoutong Sun, Manfred T. Reetz - Angewandte Chemie International Edition 2019 cited by 469

  2. Utility of B-Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability

    Authors: Zhoutong Sun, Qian Liu, Ge Qu, Yan Feng, Manfred T. Reetz - Chemical Reviews 2019 cited by 541

  3. Iterative saturation mutagenesis (ISM) for rapid directed evolution of functional enzymes

    Authors: Manfred T. Reetz, José Daniel Carballeira - Nature Protocols 2007 cited by 866

  4. Engineered enzymes for the synthesis of pharmaceuticals and other high-value products

    Authors: Manfred T. Reetz, Ge Qu, Zhoutong Sun - Nature Synthesis 2024 cited by 154

  5. Stereodivergent Protein Engineering of a Lipase To Access All Possible Stereoisomers of Chiral Esters with Two Stereocenters

    Authors: Jian Xu, Yixin Cen, Warispreet Singh, Jiajie Fan, Lian Wu, Xianfu Lin, Jiahai Zhou, Meilan Huang, Manfred T. Reetz, Qi Wu - Journal of the American Chemical Society 2019 cited by 207

  6. Reducing Codon Redundancy and Screening Effort of Combinatorial Protein Libraries Created by Saturation Mutagenesis

    Authors: Sabrina Kille, Carlos G. Acevedo‐Rocha, Loreto P. Parra, Zhigang Zhang, Diederik J. Opperman, Manfred T. Reetz, Juan Pablo Acevedo - ACS Synthetic Biology 2012 cited by 358

  7. Expanding the Range of Substrate Acceptance of Enzymes: Combinatorial Active‐Site Saturation Test

    Authors: Manfred T. Reetz, Marco Bocola, José Daniel Carballeira, Dongxing Zha, Andreas Vogel - Angewandte Chemie 2005 cited by 504

  8. Biocatalysis in Organic Chemistry and Biotechnology: Past, Present, and Future

    Authors: Manfred T. Reetz - Journal of the American Chemical Society 2013 cited by 762

  9. Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics

    Authors: Carlos G. Acevedo‐Rocha, Aitao Li, Lorenzo D’Amore, Sabrina Hoebenreich, Joaquı́n Sanchis, Paul Lubrano, Matteo P. Ferla, Marc Garcia‐Borràs, Sílvia Osuna, Manfred T. Reetz - Nature Communications 2021 cited by 123

  10. A machine learning approach for reliable prediction of amino acid interactions and its application in the directed evolution of enantioselective enzymes

    Authors: Frédéric Cadet, Nicolas Fontaine, Guangyue Li, Joaquı́n Sanchis, Matthieu Ng Fuk Chong, Rudy Pandjaitan, Iyanar Vetrivel, Bernard Offmann, Manfred T. Reetz - Scientific Reports 2018 cited by 142

  11. Laboratory Evolution of Stereoselective Enzymes: A Prolific Source of Catalysts for Asymmetric Reactions

    Authors: Manfred T. Reetz - Angewandte Chemie International Edition 2010 cited by 533

  12. Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution

    Authors: Sabrina Kille, Felipe E. Zilly, Juan Pablo Acevedo, Manfred T. Reetz - Nature Chemistry 2011 cited by 413

  13. Structure-Guided Triple-Code Saturation Mutagenesis: Efficient Tuning of the Stereoselectivity of an Epoxide Hydrolase

    Authors: Zhoutong Sun, Richard Lonsdale, Lian Wu, Guangyue Li, Aitao Li, Jian‐bo Wang, Jiahai Zhou, Manfred T. Reetz - ACS Catalysis 2016 cited by 135

  14. Can Machine Learning Revolutionize Directed Evolution of Selective Enzymes?

    Authors: Guangyue Li, Yijie Dong, Manfred T. Reetz - Advanced Synthesis & Catalysis 2019 cited by 125

  15. Making Enzymes Suitable for Organic Chemistry by Rational Protein Design

    Authors: Manfred T. Reetz - ChemBioChem 2022 cited by 70

  16. Learning from Protein Engineering by Deconvolution of Multi‐Mutational Variants

    Authors: Frank Hollmann, Joaquı́n Sanchis, Manfred T. Reetz - Angewandte Chemie International Edition 2024 cited by 40

  17. Catalytic Asymmetric Reduction of Difficult-to-Reduce Ketones: Triple-Code Saturation Mutagenesis of an Alcohol Dehydrogenase

    Authors: Zhoutong Sun, Richard Lonsdale, Adriana Ilie, Guang‐Yue Li, Jiahai Zhou, Manfred T. Reetz - ACS Catalysis 2016 cited by 141

  18. Regio‐ and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants

    Authors: Aitao Li, Carlos G. Acevedo‐Rocha, Lorenzo D’Amore, Jinfeng Chen, Yaqin Peng, Marc Garcia‐Borràs, Chenghua Gao, Jinmei Zhu, Harry Rickerby, Sílvia Osuna, Jiahai Zhou, Manfred T. Reetz - Angewandte Chemie 2020 cited by 136

  19. Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution

    Authors: Yixin Cen, Warispreet Singh, M Arkin, Thomas S. Moody, Meilan Huang, Jiahai Zhou, Qi Wu, Manfred T. Reetz - Nature Communications 2019 cited by 100

  20. Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles

    Authors: Jun‐Kuan Li, Ge Qu, Xu Li, Yuchen Tian, Chengsen Cui, Fa‐Guang Zhang, Wuyuan Zhang, Jun‐An Ma, Manfred T. Reetz, Zhoutong Sun - Nature Communications 2022 cited by 31

  21. Bacterial Biocatalysts: Molecular Biology, Three-Dimensional Structures, and Biotechnological Applications of Lipases

    Authors: K-E. Jaeger, Bauke W. Dijkstra, Manfred T. Reetz - Annual Review of Microbiology 1999 cited by 1,085

  22. Addressing the Numbers Problem in Directed Evolution

    Authors: Manfred T. Reetz, Daniel Kahakeaw, Renate Lohmer - ChemBioChem 2008 cited by 440

  23. P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping

    Authors: Carlos G. Acevedo‐Rocha, Charles G. Gamble, Richard Lonsdale, Aitao Li, Nathalie Nett, Sabrina Hoebenreich, Julia B. Lingnau, C. Wirtz, Christophe Farès, Heike Hinrichs, Alfred Deege, Adrian J. Mulholland, Yuval Nov, David Leys, Kirsty J. McLean, Andrew W. Munro, Manfred T. Reetz - ACS Catalysis 2018 cited by 172

  24. Iterative Saturation Mutagenesis on the Basis of B Factors as a Strategy for Increasing Protein Thermostability

    Authors: Manfred T. Reetz, José Daniel Carballeira, Andreas Vogel - Angewandte Chemie 2006 cited by 484