P. Nigel Leigh
Active 1951–2025
- 142
- Papers
- 30,454
- Citations
- 96
- h-index
- 140
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Medicine72.4%
- Biochemistry, Genetics and Molecular Biology12.4%
- Neuroscience11.2%
- Psychology1%
- Health Professions0.6%
- Pharmacology, Toxicology and Pharmaceutics0.5%
- Other1.9%
Topics
- Amyotrophic Lateral Sclerosis Research18.4%
- Neurogenetic and Muscular Disorders Research8.7%
- Parkinson's Disease Mechanisms and Treatments7.7%
- Alzheimer's disease research and treatments4.3%
- Genetic Neurodegenerative Diseases3.9%
- Neurological diseases and metabolism2.9%
- Other54.1%
Coauthors
- Ammar Al‐Chalabi43
- Christopher E. Shaw37
- Laura H. Goldstein24
- Martin R. Turner14
- Gilbert Bensimon12
- Sharon Abrahams12
- Brian H. Anderton11
- Christopher C.J. Miller11
- Pamela J. Shaw11
- Vincent Meininger11
- Steven Williams10
- David J. Brooks9
- C. M. Ellis8
- Steven Ackerley8
- Janet Brownlees7
- John Powell7
- Leonard H. van den Berg7
- Wim Robberecht7
- Albert C. Ludolph6
- Aleksey Shatunov6
- Andrew Simmons6
- Jan H. Veldink6
- John Moxham6
- Michael A. van Es6
All papers
- TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
Authors: Jemeen Sreedharan, Ian P. Blair, Vineeta B. Tripathi, Xun Hu, Caroline Vance, Boris Rogelj, Steven Ackerley, Jennifer C. Durnall, Kelly L. Williams, Emanuele Buratti, Francisco E. Baralle, Jacqueline de Belleroche, John D. Mitchell, P. Nigel Leigh, Ammar Al‐Chalabi, Christopher C.J. Miller, Garth A. Nicholson, Christopher E. Shaw - Science 2008 cited by 2,657
- Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
Authors: Caroline Vance, Boris Rogelj, Tibor Hortobágyi, Kurt J. De Vos, Agnes L. Nishimura, Jemeen Sreedharan, Xun Hu, Bradley Smith, Deborah Ruddy, Paul D. Wright, Jeban Ganesalingam, Kelly L. Williams, Vineeta Tripathi, Safa Al‐Saraj, Ammar Al‐Chalabi, P. Nigel Leigh, Ian P. Blair, Garth A. Nicholson, Jackie de Belleroche, Jean‐Marc Gallo, Christopher C.J. Miller, Christopher E. Shaw - Science 2009 cited by 2,599
- Dose-ranging study of riluzole in amyotrophic lateral sclerosis
Authors: Amyotrophic Lateral Sclerosis/Riluzole Study Group II, Lucette Lacomblez, Gilbert Bensimon, Vincent Meininger, P. Nigel Leigh, Philippe Guillet - The Lancet 1996 cited by 1,292
- A proposed staging system for amyotrophic lateral sclerosis
Authors: J.C. Roche, Ricard Rojas‐García, Kirsten M. Scott, William J. Scotton, Catherine Ellis, Rachel Burman, Lokesh Wijesekera, Martin R. Turner, P. Nigel Leigh, Christopher E. Shaw, Ammar Al‐Chalabi - Brain 2012 cited by 462
- Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome
Authors: Edwin Jabbari, Negin Holland, Viorica Chelban, P. Simon Jones, Ruth Lamb, Charlotte Rawlinson, Tong Guo, Alyssa Costantini, Manuela Tan, Amanda Heslegrave, Federico Roncaroli, Johannes Klein, Olaf Ansorge, Kieren Allinson, Zane Jaunmuktane, Janice L. Holton, Tamás Révész, Thomas T. Warner, Andrew J. Lees, Henrik Zetterberg, Lucy L. Russell, Martina Bocchetta, Jonathan D. Rohrer, Nigel Williams, Donald G. Grosset, David J. Burn, Nicola Pavese, Alexander Gerhard, Christopher Kobylecki, P. Nigel Leigh, Alistair Church, Michele T. M. Hu, John Woodside, Henry Houlden, James B. Rowe, Huw R. Morris - JAMA Neurology 2019 cited by 178
- Amyotrophic lateral sclerosis.
Authors: Lokesh Wijesekera, P. Nigel Leigh - Orphanet Journal of Rare Diseases 1951 cited by 948
- Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study
Authors: Martin R. Turner, Annachiara Cagnin, Federico Turkheimer, Christopher C.J. Miller, Christopher E. Shaw, David J. Brooks, P. Nigel Leigh, Richard B. Banati - Neurobiology of Disease 2004 cited by 727
- Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study
Authors: Ammar Al‐Chalabi, Andrea Calvo, Adriano Chiò, Shuna Colville, Cathy Ellis, Orla Hardiman, Mark Heverin, Robin Howard, Mark Huisman, Noa Keren, P. Nigel Leigh, Letizia Mazzini, Gabriele Mora, Richard W. Orrell, James Rooney, Kirsten M. Scott, William J. Scotton, Meinie Seelen, Christopher E. Shaw, Katie Sidle, Robert Swingler, Miho Tsuda, Jan H. Veldink, Anne E Visser, Leonard H. van den Berg, Neil Pearce - The Lancet Neurology 2014 cited by 425
- Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study
Authors: Edwin Jabbari, Shunsuke Koga, Rebecca R. Valentino, Regina H. Reynolds, Raffaele Ferrari, Manuela Tan, James B. Rowe, Clifton L. Dalgard, Sonja W. Scholz, Dennis W. Dickson, Thomas T. Warner, Tamás Révész, Günter U. Höglinger, Owen A. Ross, Mina Ryten, John Hardy, Maryam Shoai, Huw R. Morris, Kin Y. Mok, David Murphy, Safa Al‐Sarraj, Claire Troakes, Steve M. Gentleman, Kieren Allinson, Zane Jaunmuktane, Janice L. Holton, Andrew J. Lees, Christopher M. Morris, Yaroslau Compta, Ellen Gelpí, John C. van Swieten, Alex Rajput, Leslie W. Ferguson, Mark Cookson, J. Raphael Gibbs, Cornelis Blauwendraat, Jinhui Ding, Ruth Chia, Bryan J. Traynor, Alexander Pantelyat, Coralie Viollet, Bryan J. Traynor, Olga Pletniková, Juan C. Troncoso, Liana S. Rosenthal, Adam L. Boxer, Gesine Respondek, Thomas Arzberger, Sigrun Roeber, Armin Giese, David J. Burn, Nicola Pavese, Alexander Gerhard, Christopher Kobylecki, P. Nigel Leigh, Alistair Church, Michele T.M. Hu - The Lancet Neurology 2020 cited by 120
- NEK1 variants confer susceptibility to amyotrophic lateral sclerosis
Authors: Kevin P. Kenna, Perry T.C. van Doormaal, Annelot M. Dekker, Nicola Ticozzi, Brendan Kenna, Frank P. Diekstra, Wouter van Rheenen, Kristel R. van Eijk, Ashley R Jones, Pamela Keagle, Aleksey Shatunov, William Sproviero, Bradley Smith, Michael A. van Es, Simon Topp, Aoife Kenna, Jack W. Miller, Claudia Fallini, Cinzia Tiloca, Russell L. McLaughlin, Caroline Vance, Claire Troakes, Claudia Colombrita, Gabriele Mora, Andrea Calvo, Federico Verde, Safa Al‐Sarraj, Andrew King, Daniela Calini, Jacqueline de Belleroche, Frank Baas, Anneke J. van der Kooi, Marianne de Visser, Anneloor L.M.A. ten Asbroek, Peter C. Sapp, Diane McKenna‐Yasek, Meraida Polak, Seneshaw Asress, José Luís Muñoz-Blanco, Tim M. Strom, Thomas Meitinger, Karen Morrison, Giuseppe Lauria, Kelly L. Williams, P. Nigel Leigh, Garth A. Nicholson, Ian P. Blair, Claire S. Leblond, Patrick A. Dion, Guy A. Rouleau, Hardev Pall, Pamela J. Shaw, Martin R. Turner, Kevin Talbot, Franco Taroni, Khrista Boylan, Marka van Blitterswijk, Rosa Rademakers, Jesús Esteban‐Pérez, Alberto García‐Redondo, Phillip Van Damme, Wim Robberecht, Adriano Chiò, Cinzia Gellera, Carsten Drepper, Michael Sendtner, Antonia Ratti, Jonathan D. Glass, Jesús S. Mora, Nazlı Başak, Orla Hardiman, Albert C. Ludolph, Peter M. Andersen, Jochen H. Weishaupt, Robert H. Brown, Ammar Al‐Chalabi, Vincenzo Silani, Christopher E. Shaw, Leonard H. van den Berg, Jan H. Veldink, John E. Landers - Nature Genetics 2016 cited by 294
- Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study
Authors: Ton Fang, Ahmad Al Khleifat, Jacques-Henri Meurgey, Ashley Jones, P. Nigel Leigh, Gilbert Bensimon, Ammar Al‐Chalabi - The Lancet Neurology 2018 cited by 252
- Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis
Authors: Michael A. van Es, Jan H. Veldink, Christiaan G. J. Saris, Hylke M. Blauw, Paul W.J. van Vught, Anna Birve, Robin Lemmens, Helenius J. Schelhaas, Ewout J. N. Groen, Mark Huisman, Anneke J. van der Kooi, Marianne de Visser, Caroline Dahlberg, Karol Estrada, Fernando Rivadeneira, Albert Hofman, Machiel J. Zwarts, Perry T.C. van Doormaal, Dan Rujescu, Eric Strengman, Ina Giegling, Pierandrea Muglia, Barbara Tomik, Agnieszka Słowik, André G. Uitterlinden, Corinna Hendrich, Stefan Waibel, Thomas Meyer, Albert C. Ludolph, Jonathan D. Glass, Shaun Purcell, Sven Cichon, Markus M. Nöthen, H‐Erich Wichmann, Stefan Schreiber, Sita H. Vermeulen, Lambertus A. Kiemeney, John H. J. Wokke, Simon Cronin, Russell L. McLaughlin, Orla Hardiman, Katsumi Fumoto, R. Jeroen Pasterkamp, Vincent Meininger, Judith Melki, P. Nigel Leigh, Christopher E. Shaw, John E. Landers, Ammar Al‐Chalabi, Robert H. Brown, Wim Robberecht, Peter M. Andersen, Roel A. Ophoff, Leonard H. van den Berg - Nature Genetics 2009 cited by 404
- Repeated 5-day cycles of low dose aldesleukin in amyotrophic lateral sclerosis (IMODALS): A phase 2a randomised, double-blind, placebo-controlled trial
Authors: William Camu, Marius Mickunas, Jean‐Luc Veyrune, Christine Payan, Cecília Garlanda, Massimo Locati, Raúl Juntas‐Morales, Nicolas Pageot, Andrea Malaspina, Ulf Andréasson, Janine Kirby, Carey Suehs, Safa Saker, Christophe Masseguin, John De Vos, Henrik Zetterberg, Pamela J. Shaw, Ammar Al‐Chalabi, P. Nigel Leigh, Timothy Tree, Gilbert Bensimon - EBioMedicine 2020 cited by 80
- Neurofilament light levels predict clinical progression and death in multiple system atrophy
Authors: Viorica Chelban, Elham Nikram, Alexandra Pérez‐Soriano, Carlo Wilke, Alexandra Foubert‐Samier, Nirosen Vijiaratnam, Tong Guo, Edwin Jabbari, Simisola Olufodun, Mariel Gonzalez, Konstantin Senkevich, Brice Laurens, Patrice Péran, Olivier Rascol, Anne Pavy‐Le Traon, Emily Todd, Alyssa Costantini, Sondos Alikhwan, Ambreen Tariq, Bai Lin Ng, Esteban Muñoz, Cèlia Painous, Yaroslau Compta, Carme Junqué, Bàrbara Segura, Kristina Zhelcheska, Henny Wellington, Lüdger Schöls, Zane Jaunmuktane, Christopher Kobylecki, Alistair Church, Michele T M Hu, James B. Rowe, P. Nigel Leigh, Luke A. Massey, David J. Burn, Nicola Pavese, Thomas Foltynie, Sofya Pchelina, Nicholas Wood, Amanda Heslegrave, Henrik Zetterberg, Martina Bocchetta, Jonathan D. Rohrer, Marı́a José Martı́, Matthis Synofzik, Huw R. Morris, Wassilios G. Meissner, Henry Houlden - Brain 2022 cited by 73
- An estimate of amyotrophic lateral sclerosis heritability using twin data
Authors: Ammar Al‐Chalabi, Fang Fang, Martha F. Hanby, P. Nigel Leigh, Christopher E. Shaw, Weimin Ye, Frühling Rijsdijk - Journal of Neurology Neurosurgery & Psychiatry 2010 cited by 329
- The sex ratio in amyotrophic lateral sclerosis: A population based study
Authors: Zita R. Manjaly, Kirsten M. Scott, Abhinav Kumar, Lokesh Wijesekera, Jeban Ganesalingam, Laura H. Goldstein, Anna Janssen, Andrew Dougherty, Emma Willey, Biba Stanton, Martin R. Turner, Mary‐Ann Ampong, Mohammed Sakel, Richard W. Orrell, Robin Howard, Christopher E. Shaw, P. Nigel Leigh, Ammar Al‐Chalabi - Amyotrophic Lateral Sclerosis 2010 cited by 211
- Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases
Authors: Jason Chen, Zhongbo Chen, Hyejung Won, Alden Huang, Jennifer K. Lowe, Kevin Wojta, Jennifer S. Yokoyama, Gilbert Bensimon, P. Nigel Leigh, C. Payán, Aleksey Shatunov, Ashley R. Jones, Cathryn M. Lewis, Panagiotis Deloukas, Philippe Amouyel, Christophe Tzourio, Jean‐François Dartigues, Albert Ludolph, Adam L. Boxer, Jeff M. Bronstein, Ammar Al‐Chalabi, Daniel H. Geschwind, Giovanni Coppola - Molecular Neurodegeneration 2018 cited by 137
- Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis
Authors: Michael J. Strong, Gloria M. Grace, Morris Freedman, Cathy Lomen-Hoerth, Susan Woolley, Laura H. Goldstein, Jennifer Murphy, Christen Shoesmith, Jeffery Rosenfeld, P. Nigel Leigh, Lucie Bruijn, Paul G. Ince, Denise A. Figlewicz - Amyotrophic Lateral Sclerosis 2009 cited by 539
- Neurite orientation and dispersion density imaging (NODDI) detects cortical and corticospinal tract degeneration in ALS
Authors: Rebecca Broad, Matt C. Gabel, Nicholas G. Dowell, David J. Schwartzman, Anil K. Seth, Hui Zhang, Daniel C. Alexander, Mara Cercignani, P. Nigel Leigh - Journal of Neurology Neurosurgery & Psychiatry 2018 cited by 101
- Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: The NNIPPS Study
Authors: Gilbert Bensimon, Albert Ludolph, Yves Agid, Marie Vidailhet, Christine Payan, P. Nigel Leigh - Brain 2008 cited by 346
- Variants of the elongator protein 3 ( ELP3 ) gene are associated with motor neuron degeneration
Authors: Claire L. Simpson, Robin Lemmens, Katarzyna Miśkiewicz, Wendy Broom, Valerie K. Hansen, Paul W.J. van Vught, John E. Landers, Peter C. Sapp, Ludo Van Den Bosch, Jo Knight, Benjamin M. Neale, Martin R. Turner, Jan H. Veldink, Roel A. Ophoff, Vineeta B. Tripathi, Ana Beleza, Meera N. Shah, Petroula Proitsi, Annelies Van Hoecke, Peter Carmeliet, H. Robert Horvitz, P. Nigel Leigh, Christopher E. Shaw, Leonard H. van den Berg, Pak C. Sham, John Powell, Patrik Verstreken, Robert H. Brown, Wim Robberecht, Ammar Al‐Chalabi - Human Molecular Genetics 2008 cited by 291
- Estimating clinical stage of amyotrophic lateral sclerosis from the ALS Functional Rating Scale
Authors: Rubika Balendra, Ashley Jones, Naheed Jivraj, Catherine Knights, C. M. Ellis, Rachel Burman, Martin R. Turner, P. Nigel Leigh, Christopher E. Shaw, Ammar Al‐Chalabi - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2014 cited by 154
- A confirmatory dose-ranging study of riluzole in ALS
Authors: Lucette Lacomblez, Gilbert Bensimon, P. Nigel Leigh, Philippe Guillet, Larry K. Powe, Sylvain Durrleman, Jean-Christophe Delumeau, Vincent Meininger - Neurology 1996 cited by 199
- Characterizing axonal myelination within the healthy population: a tract-by-tract mapping of effects of age and gender on the fiber g-ratio
Authors: Mara Cercignani, Giovanni Giulietti, Nick G. Dowell, Matt C. Gabel, Rebecca Broad, P. Nigel Leigh, Neil A. Harrison, Marco Bozzali - Neurobiology of Aging 2016 cited by 104
