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Regis J. O’Keefe

Active 1988–2025

126
Papers
19,923
Citations
91
h-index
124
i10-index

Citations

Citations per year for Regis J. O’Keefe1986: 1 citations1989: 2 citations1990: 2 citations1991: 3 citations1992: 10 citations1993: 5 citations1994: 8 citations1995: 4 citations1996: 3 citations1997: 6 citations1998: 3 citations1999: 19 citations2000: 32 citations2001: 44 citations2002: 85 citations2003: 109 citations2004: 132 citations2005: 132 citations2006: 161 citations2007: 174 citations2008: 190 citations2009: 205 citations2010: 213 citations2011: 184 citations2012: 231 citations2013: 198 citations2014: 238 citations2015: 185 citations2016: 184 citations2017: 140 citations2018: 96 citations2019: 491 citations2020: 536 citations2021: 436 citations2022: 430 citations2023: 313 citations2024: 466 citations2025: 201 citations2026: 8 citations1987–1988: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 1,983 citing papers, 30.1% of this breakdownChina: 1,196 citing papers, 18.1% of this breakdownUnited Kingdom: 367 citing papers, 5.6% of this breakdownGermany: 309 citing papers, 4.7% of this breakdownJapan: 286 citing papers, 4.3% of this breakdownCanada: 201 citing papers, 3.1% of this breakdownAustralia: 184 citing papers, 2.8% of this breakdownItaly: 166 citing papers, 2.5% of this breakdownNetherlands: 162 citing papers, 2.5% of this breakdownFrance: 143 citing papers, 2.2% of this breakdownSpain: 128 citing papers, 1.9% of this breakdownSwitzerland: 127 citing papers, 1.9% of this breakdown
0%30.1%Other 20.3%

Institutions

Fields

  • Medicine60.3%
  • Biochemistry, Genetics and Molecular Biology28.8%
  • Engineering4.5%
  • Immunology and Microbiology1.1%
  • Materials Science1.1%
  • Dentistry0.9%
  • Other3.3%

Topics

  • Osteoarthritis Treatment and Mechanisms8.5%
  • Bone Metabolism and Diseases6.8%
  • Bone health and treatments4.5%
  • Bone health and osteoporosis research4%
  • TGF-β signaling in diseases2.5%
  • Bone Tissue Engineering Materials2.5%
  • Other71.2%

Coauthors

All papers

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  1. LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis

    Authors: Manoj Arra, Gaurav Swarnkar, Ke Ke, Jesse E. Otero, Jun Ying, Xin Duan, Takashi Maruyama, Muhammad Farooq, Regis J. O’Keefe, Gabriel Mbalaviele, Jie Shen, Yousef Abu‐Amer - Nature Communications 2020 cited by 394

  2. Atypical Subtrochanteric and Diaphyseal Femoral Fractures: Second Report of a Task Force of the American Society for Bone and Mineral Research

    Authors: Elizabeth Shane, David B. Burr, Bo Abrahamsen, Robert A. Adler, Thomas D. Brown, Angela M. Cheung, Felicia Cosman, Jeffrey R. Curtis, Richard Dell, David W. Dempster, Peter R. Ebeling, Thomas A. Einhorn, Harry K. Genant, Piet Geusens, Klaus Klaushofer, Joseph M. Lane, Fergus McKiernan, Ross E. McKinney, Alvin Choong Meng Ng, Jeri W. Nieves, Regis J. O’Keefe, Socrates E. Papapoulos, Tet Sen Howe, Marjolein C. H. van der Meulen, Robert S. Weinstein, Michael P. Whyte - Journal of Bone and Mineral Research 2013 cited by 2,118

  3. FoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis

    Authors: Cuicui Wang, Jie Shen, Jun Ying, Ding Xiao, Regis J. O’Keefe - National Academy of Sciences, Proceedings of the National Academy of Sciences 2020 cited by 105

  4. Inflammation and epigenetic regulation in osteoarthritis

    Authors: Jie Shen, Yousef Abu‐Amer, Regis J. O’Keefe, Audrey McAlinden - Connective Tissue Research 2016 cited by 226

  5. What is the Impact of Social Deprivation on Physical and Mental Health in Orthopaedic Patients?

    Authors: Melissa A. Wright, Muyibat A. Adelani, Christopher J. Dy, Regis J. O’Keefe, Ryan P. Calfee - Clinical Orthopaedics and Related Research 2019 cited by 134

  6. Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

    Authors: Mei Zhu, Dezhi Tang, Qiuqian Wu, Suyang Hao, Mo Chen, Chao Xie, Randy N. Rosier, Regis J. O’Keefe, Michael J. Zuscik, Di Chen - Journal of Bone and Mineral Research 2008 cited by 482

  7. Articular Cartilage Biology

    Authors: Michael Ulrich‐Vinther, Michael D. Maloney, Edward M. Schwarz, Randy N. Rosier, Regis J. O’Keefe - Journal of the American Academy of Orthopaedic Surgeons 2003 cited by 281

  8. Bone Tissue Engineering and Regeneration: From Discovery to the Clinic—An Overview

    Authors: Regis J. O’Keefe, Jeremy J. Mao - Tissue Engineering Part B Reviews 2011 cited by 280

  9. Runx2 plays a central role in Osteoarthritis development

    Authors: Di Chen, Dongyeon J. Kim, Jie Shen, Zhen Zou, Regis J. O’Keefe - Journal of Orthopaedic Translation 2019 cited by 100

  10. Magnesium facilitates the healing of atypical femoral fractures: A single-cell transcriptomic study

    Authors: Nianye Zheng, Jiankun Xu, Ye Chun Ruan, Liang Chang, Xinluan Wang, Hao Yao, Jiali Wang, Ri Zhang, Qingyun Xue, Ning Tang, Tim-yun Ong, Jörg Schilcher, Regis J. O’Keefe, Ling Qin - Materials Today 2022 cited by 47

  11. NOTCH signaling in skeletal progenitors is critical for fracture repair

    Authors: Cuicui Wang, Jason A. Inzana, Anthony J. Mirando, Yinshi Ren, Zhaoyang Liu, Jie Shen, Regis J. O’Keefe, Hani A. Awad, Matthew J. Hilton - Journal of Clinical Investigation 2016 cited by 122

  12. Periosteal Progenitor Cell Fate in Segmental Cortical Bone Graft Transplantations: Implications for Functional Tissue Engineering

    Authors: Xinping Zhang, Chao Xie, Angela Lin, Hiromu Ito, Hani A. Awad, Jay R. Lieberman, Paul T. Rubery, Edward M. Schwarz, Regis J. O’Keefe, Robert E. Guldberg - Journal of Bone and Mineral Research 2005 cited by 353

  13. BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development

    Authors: Bing Shu, Ming Zhang, Rong Xie, Meina Wang, Hongting Jin, Wei Hou, Dezhi Tang, Stephen E. Harris, Yuji Mishina, Regis J. O’Keefe, Matthew J. Hilton, Yongjun Wang, Di Chen - Journal of Cell Science 2011 cited by 265

  14. TNF.ALPHA. and pathologic bone resorption

    Authors: Brendan Boyce, Ping Li, Zhenqiang Yao, Qian Zhang, I.R. Badell, Edward M. Schwarz, Regis J. O’Keefe, Lianping Xing - The Keio Journal of Medicine 2005 cited by 260

  15. Inhibition of β‐catenin signaling in articular chondrocytes results in articular cartilage destruction

    Authors: Mei Zhu, Mo Chen, Michael J. Zuscik, Qiuqian Wu, Yongjun Wang, Randy N. Rosier, Regis J. O’Keefe, Di Chen - Arthritis & Rheumatism 2008 cited by 257

  16. Malic Enzyme 1 Absence in Synovial Sarcoma Shifts Antioxidant System Dependence and Increases Sensitivity to Ferroptosis Induction with ACXT-3102

    Authors: Caitlyn B. Brashears, Bethany C. Prudner, Richa Rathore, Katharine E. Caldwell, Carina Dehner, Jane L. Buchanan, Sara E.S. Lange, Neal Poulin, Jennifer K. Sehn, Jason Roszik, Dirk Spitzer, Kevin B. Jones, Regis J. O’Keefe, Torsten O. Nielsen, Eric B. Taylor, Jason M. Held, William G. Hawkins, Brian A. Van Tine - Clinical Cancer Research 2022 cited by 31

  17. A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis

    Authors: Zhaoyang Liu, Jianquan Chen, Anthony J. Mirando, Cuicui Wang, Michael J. Zuscik, Regis J. O’Keefe, Matthew J. Hilton - Science Signaling 2015 cited by 118

  18. Deletion of Glut1 in early postnatal cartilage reprograms chondrocytes toward enhanced glutamine oxidation

    Authors: Cuicui Wang, Jun Ying, Xiangfeng Niu, Xiaofei Li, Gary J. Patti, Jie Shen, Regis J. O’Keefe - Bone Research 2021 cited by 40

  19. Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene

    Authors: Yasuhiko Nishio, Yufeng Dong, Mark Paris, Regis J. O’Keefe, Edward M. Schwarz, Hicham Drissi - Gene 2006 cited by 342

  20. Regulation of chondrogenesis and chondrocyte differentiation by stress

    Authors: Michael J. Zuscik, Matthew J. Hilton, Xinping Zhang, Di Chen, Regis J. O’Keefe - Journal of Clinical Investigation 2008 cited by 251

  21. Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor

    Authors: Yu‐Feng Dong, Do Y. Soung, Edward M. Schwarz, Regis J. O’Keefe, Hicham Drissi - Journal of Cellular Physiology 2006 cited by 247

  22. Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice

    Authors: Jie Shen, Cuicui Wang, Jun Ying, Taotao Xu, Audrey McAlinden, Regis J. O’Keefe - JCI Insight 2019 cited by 43

  23. Deletion of the Transforming Growth Factor β Receptor Type II Gene in Articular Chondrocytes Leads to a Progressive Osteoarthritis‐like Phenotype in Mice

    Authors: Jie Shen, Jia Li, Baoli Wang, Hongting Jin, Meina Wang, Yejia Zhang, Yunzhi Yang, Hee‐Jeong Im, Regis J. O’Keefe, Di Chen - Arthritis & Rheumatism 2013 cited by 207

  24. RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development

    Authors: Yufeng Dong, Alana M. Jesse, Anat Kohn, Lea M. Gunnell, Tasuku Honjo, Michael J. Zuscik, Regis J. O’Keefe, Matthew J. Hilton - Development 2010 cited by 179