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Robert J. Lefkowitz

Active 1970–2025

484
Papers
138,466
Citations
213
h-index
482
i10-index

Citations

Citations per year for Robert J. Lefkowitz1970: 6 citations1971: 15 citations1972: 17 citations1973: 36 citations1974: 50 citations1975: 57 citations1976: 127 citations1977: 161 citations1978: 205 citations1979: 211 citations1980: 280 citations1981: 203 citations1982: 185 citations1983: 187 citations1984: 179 citations1985: 225 citations1986: 228 citations1987: 399 citations1988: 461 citations1989: 512 citations1990: 590 citations1991: 603 citations1992: 674 citations1993: 812 citations1994: 724 citations1995: 811 citations1996: 1,014 citations1997: 1,037 citations1998: 1,157 citations1999: 1,465 citations2000: 1,389 citations2001: 1,464 citations2002: 1,346 citations2003: 1,532 citations2004: 1,581 citations2005: 1,309 citations2006: 1,525 citations2007: 1,332 citations2008: 1,164 citations2009: 975 citations2010: 1,266 citations2011: 1,255 citations2012: 939 citations2013: 930 citations2014: 755 citations2015: 789 citations2016: 785 citations2017: 884 citations2018: 776 citations2019: 2,131 citations2020: 1,969 citations2021: 2,004 citations2022: 1,465 citations2023: 985 citations2024: 1,561 citations2025: 635 citations2026: 6 citations

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 10,153 citing papers, 43.5% of this breakdownUnited Kingdom: 1,519 citing papers, 6.5% of this breakdownGermany: 1,427 citing papers, 6.1% of this breakdownChina: 1,220 citing papers, 5.2% of this breakdownCanada: 984 citing papers, 4.2% of this breakdownFrance: 972 citing papers, 4.2% of this breakdownJapan: 837 citing papers, 3.6% of this breakdownItaly: 742 citing papers, 3.2% of this breakdownAustralia: 548 citing papers, 2.4% of this breakdownSwitzerland: 437 citing papers, 1.9% of this breakdownSpain: 396 citing papers, 1.7% of this breakdownNetherlands: 393 citing papers, 1.7% of this breakdown
0%43.5%Other 15.8%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology55.2%
  • Medicine25.3%
  • Neuroscience12.3%
  • Immunology and Microbiology2.6%
  • Agricultural and Biological Sciences0.9%
  • Psychology0.8%
  • Other2.9%

Topics

  • Receptor Mechanisms and Signaling14.4%
  • Neuropeptides and Animal Physiology6%
  • Protein Kinase Regulation and GTPase Signaling3.8%
  • Neuroscience and Neuropharmacology Research3.3%
  • Ion channel regulation and function2%
  • Cellular transport and secretion1.7%
  • Other68.8%

Coauthors

All papers

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  1. Biased signalling: from simple switches to allosteric microprocessors

    Authors: Jeffrey S. Smith, Robert J. Lefkowitz, Sudarshan Rajagopal - Nature Reviews Drug Discovery 2018 cited by 745

  2. Seven-transmembrane receptors

    Authors: Kristen L. Pierce, Richard T. Premont, Robert J. Lefkowitz - Nature Reviews Molecular Cell Biology 2002 cited by 2,690

  3. GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

    Authors: A. Thomsen, Bianca Plouffe, Thomas J. Cahill, Arun K. Shukla, Jeffrey Tarrasch, Annie Dosey, Alem W. Kahsai, Ryan T. Strachan, Biswaranjan Pani, Jacob P. Mahoney, Li-Yin Huang, Billy Breton, Franziska M. Heydenreich, Roger K. Sunahara, Georgios Skiniotis, Michel Bouvier, Robert J. Lefkowitz - Cell 2016 cited by 578

  4. Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc

    Authors: Dean P. Staus, Hongli Hu, Michael J. Robertson, A.L.W. Kleinhenz, Laura M. Wingler, W. Darrell Capel, Naomi R. Latorraca, Robert J. Lefkowitz, Georgios Skiniotis - Nature 2020 cited by 367

  5. Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR

    Authors: Laura M. Wingler, Meredith A. Skiba, Conor McMahon, Dean P. Staus, A.L.W. Kleinhenz, Carl‐Mikael Suomivuori, Naomi R. Latorraca, Ron O. Dror, Robert J. Lefkowitz, Andrew C. Kruse - Science 2020 cited by 247

  6. Conformational Basis of G Protein-Coupled Receptor Signaling Versatility

    Authors: Laura M. Wingler, Robert J. Lefkowitz - Trends in Cell Biology 2020 cited by 229

  7. Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2

    Authors: Laura Bohn, Robert J. Lefkowitz, Raul R. Gainetdinov, Karsten Peppel, Marc G. Caron, Fang‐Tsyr Lin - Science 1999 cited by 1,079

  8. Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

    Authors: Thomas J. Cahill, A. Thomsen, Jeffrey Tarrasch, Bianca Plouffe, Anthony H. Nguyen, Fan Yang, Li-Yin Huang, Alem W. Kahsai, Daniel L. Bassoni, Bryant J. Gavino, Jane E. Lamerdin, Sarah Triest, Arun K. Shukla, Benjamin Berger, John R. Little, Albert Antar, Adi Blanc, Chang-xiu Qu, Xin Chen, Kouki Kawakami, Asuka Inoue, Junken Aoki, Jan Steyaert, Jin‐Peng Sun, Michel Bouvier, Georgios Skiniotis, Robert J. Lefkowitz - National Academy of Sciences, Proceedings of the National Academy of Sciences 2017 cited by 385

  9. Transduction of Receptor Signals by ß-Arrestins

    Authors: Robert J. Lefkowitz, Sudha K. Shenoy - Science 2005 cited by 1,721

  10. Distinct Phosphorylation Sites on the β 2 -Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin

    Authors: Kelly N. Nobles, Kunhong Xiao, Seungkirl Ahn, Arun K. Shukla, Christopher M. Lam, Sudarshan Rajagopal, Ryan T. Strachan, Teng‐Yi Huang, Erin A. Bressler, Makoto R. Hara, Sudha K. Shenoy, Steven P. Gygi, Robert J. Lefkowitz - Science Signaling 2011 cited by 625

  11. Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor

    Authors: Carl‐Mikael Suomivuori, Naomi R. Latorraca, Laura M. Wingler, Stephan Eismann, Matthew C. King, A.L.W. Kleinhenz, Meredith A. Skiba, Dean P. Staus, Andrew C. Kruse, Robert J. Lefkowitz, Ron O. Dror - Science 2020 cited by 242

  12. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations

    Authors: Laura M. Wingler, Matthias Elgeti, Daniel Hilger, Naomi R. Latorraca, Michael T. Lerch, Dean P. Staus, Ron O. Dror, Brian K. Kobilka, Wayne L. Hubbell, Robert J. Lefkowitz - Cell 2019 cited by 296

  13. Mechanism of β 2 AR regulation by an intracellular positive allosteric modulator

    Authors: Xiangyu Liu, Ali Masoudi, Alem W. Kahsai, Li-Yin Huang, Biswaranjan Pani, Dean P. Staus, Paul J. Shim, Kunio Hirata, Rishabh K. Simhal, Allison M. Schwalb, Paula Rambarat, Seungkirl Ahn, Robert J. Lefkowitz, Brian K. Kobilka - Science 2019 cited by 133

  14. A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1

    Authors: Makoto R. Hara, Jeffrey J. Kovacs, Erin J. Whalen, Sudarshan Rajagopal, Ryan T. Strachan, Wayne Grant, Aaron J. Towers, Barbara Williams, Christopher M. Lam, Kunhong Xiao, Sudha K. Shenoy, Simon G. Gregory, Seungkirl Ahn, Derek R. Duckett, Robert J. Lefkowitz - Nature 2011 cited by 418

  15. μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence

    Authors: Laura Bohn, Raul R. Gainetdinov, Fang‐Tsyr Lin, Robert J. Lefkowitz, Marc G. Caron - Nature 2000 cited by 923

  16. β-arrestin-mediated receptor trafficking and signal transduction

    Authors: Sudha K. Shenoy, Robert J. Lefkowitz - Trends in Pharmacological Sciences 2011 cited by 699

  17. A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling

    Authors: James W. Wisler, Scott M. DeWire, Erin J. Whalen, Jonathan D. Violin, Matthew T. Drake, Seungkirl Ahn, Sudha K. Shenoy, Robert J. Lefkowitz - National Academy of Sciences, Proceedings of the National Academy of Sciences 2007 cited by 598

  18. Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

    Authors: Dean P. Staus, Ryan T. Strachan, Aashish Manglik, Biswaranjan Pani, Alem W. Kahsai, Tae Hun Kim, Laura M. Wingler, Seungkirl Ahn, Arnab K. Chatterjee, Ali Masoudi, Andrew C. Kruse, Els Pardon, Jan Steyaert, William I. Weis, R. Scott Prosser, Brian K. Kobilka, Tommaso Costa, Robert J. Lefkowitz - Nature 2016 cited by 328

  19. Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure

    Authors: Xiangyu Liu, Seungkirl Ahn, Alem W. Kahsai, Kai-Cheng Meng, Naomi R. Latorraca, Biswaranjan Pani, AJ Venkatakrishnan, Ali Masoudi, William I. Weis, Ron O. Dror, Xin Chen, Robert J. Lefkowitz, Brian K. Kobilka - Nature 2017 cited by 206

  20. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

    Authors: A. De Léan, Jeffrey M. Stadel, Robert J. Lefkowitz - Journal of Biological Chemistry 1980 cited by 1,605

  21. β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

    Authors: Martin J. Lohse, Jeffrey Benovic, Juan Codina, Marc G. Caron, Robert J. Lefkowitz - Science 1990 cited by 1,217

  22. β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7

    Authors: Sudarshan Rajagopal, Ji‐Hee Kim, Seungkirl Ahn, Stewart Craig, Christopher M. Lam, Norma P. Gerard, Craig Gerard, Robert J. Lefkowitz - National Academy of Sciences, Proceedings of the National Academy of Sciences 2009 cited by 595

  23. Visualization of arrestin recruitment by a G-protein-coupled receptor

    Authors: Arun K. Shukla, Gerwin Westfield, Kunhong Xiao, Rosana I. Reis, Li-Yin Huang, Prachi Tripathi‐Shukla, Jiang Qian, Sheng Li, Adi Blanc, Austin N. Oleskie, Anne M. Dosey, Min Su, Cui-Rong Liang, Ling-Ling Gu, Jin-Ming Shan, Xin Chen, Rachel Hanna, Minjung Choi, Yao Xiao, B.U. Klink, Alem W. Kahsai, Sachdev S. Sidhu, Shohei Koide, Pawel A. Penczek, Anthony A. Kossiakoff, Virgil L. Woods, Brian K. Kobilka, Georgios Skiniotis, Robert J. Lefkowitz - Nature 2014 cited by 508

  24. Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

    Authors: Arun K. Shukla, Aashish Manglik, Andrew C. Kruse, Kunhong Xiao, Rosana I. Reis, Wei-Chou Tseng, Dean P. Staus, Daniel Hilger, Serdar Uysal, Li-Yin Huang, Marcin Paduch, Prachi Tripathi‐Shukla, Akiko Koide, Shohei Koide, William I. Weis, Anthony A. Kossiakoff, Brian K. Kobilka, Robert J. Lefkowitz - Nature 2013 cited by 476