Roberto Zoncu
Active 2002–2025
- 66
- Papers
- 27,591
- Citations
- 48
- h-index
- 60
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Medicine46.4%
- Biochemistry, Genetics and Molecular Biology43%
- Neuroscience3.4%
- Immunology and Microbiology3.1%
- Agricultural and Biological Sciences0.8%
- Nursing0.7%
- Other2.6%
Topics
- Autophagy in Disease and Therapy6.9%
- Ferroptosis and cancer prognosis6.4%
- Cellular transport and secretion3.4%
- RNA modifications and cancer3.3%
- PI3K/AKT/mTOR signaling in cancer3.1%
- Cancer, Lipids, and Metabolism2.9%
- Other74%
Coauthors
- Rushika M. Perera16
- Derek Toomre13
- David M. Sabatini12
- Daniel K. Nomura8
- Guillermo Ayala8
- James H. Hurley7
- María Elena Díaz7
- Rafael Sebastián7
- Alejo Efeyan6
- Chun-Yan Lim6
- Hijai R. Shin6
- Pietro De Camilli6
- Rosalie Lawrence6
- Liron Bar‐Peled5
- Oliver B. Davis5
- James A. Olzmann4
- Y. Rose Citron4
- Aakriti Jain3
- Ashley Thelen3
- Brian M. Castellano3
- Charles A. Berdan3
- Dojin Kim3
- Douglas F. Covey3
- Ester Díaz3
All papers
- The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
Authors: Kirill Bersuker, Joseph M. Hendricks, Zhipeng Li, Leslie Magtanong, Breanna Ford, Peter Tang, Melissa A. Roberts, Bingqi Tong, Thomas J. Maimone, Roberto Zoncu, Michael C. Bassik, Daniel K. Nomura, Scott J. Dixon, James A. Olzmann - Nature 2019 cited by 3,681
- A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
Authors: Carmine Settembre, Roberto Zoncu, Diego L. Medina, Francesco Vetrini, Serkan Erdin, SerpilUckac Erdin, Tuong Huynh, Mathieu Ferron, Gérard Karsenty, Michel Vellard, Valeria Facchinetti, David M. Sabatini, Andrea Ballabio - The EMBO Journal 2012 cited by 1,920
- The lysosome as a cellular centre for signalling, metabolism and quality control
Authors: Rosalie Lawrence, Roberto Zoncu - Nature Cell Biology 2018 cited by 914
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
Authors: Yasemin Sancak, Liron Bar‐Peled, Roberto Zoncu, Andrew L. Markhard, Shigeyuki Nada, David M. Sabatini - Cell 2010 cited by 2,478
- mTOR: from growth signal integration to cancer, diabetes and ageing
Authors: Roberto Zoncu, Alejo Efeyan, David M. Sabatini - Nature Reviews Molecular Cell Biology 2010 cited by 3,945
- DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy
Authors: Truc B. Nguyen, Sharon M. Louie, Joseph R. Daniele, Quân Tran, Andrew Dillin, Roberto Zoncu, Daniel K. Nomura, James A. Olzmann - Developmental Cell 2017 cited by 613
- The Lysosome as a Regulatory Hub
Authors: Rushika M. Perera, Roberto Zoncu - Annual Review of Cell and Developmental Biology 2016 cited by 653
- mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H + -ATPase
Authors: Roberto Zoncu, Liron Bar‐Peled, Alejo Efeyan, Shuyu Wang, Yasemin Sancak, David M. Sabatini - Science 2011 cited by 1,633
- Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism
Authors: Rushika M. Perera, Svetlana Stoykova, Brandon Nicolay, Kenneth N. Ross, Julien Fitamant, Myriam Boukhali, Justine Lengrand, Vikram Deshpande, Martin K. Selig, Cristina R. Ferrone, Jeff Settleman, Gregory Stephanopoulos, Nicholas J. Dyson, Roberto Zoncu, Sridhar Ramaswamy, Wilhelm Haas, Nabeel Bardeesy - Nature 2015 cited by 807
- Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex
Authors: Brian M. Castellano, Ashley Thelen, Ofer Moldavski, McKenna Feltes, Reini E.N. van der Welle, Laurel Mydock‐McGrane, Xuntian Jiang, Robert J. van Eijkeren, Oliver B. Davis, Sharon M. Louie, Rushika M. Perera, Douglas F. Covey, Daniel K. Nomura, Daniel S. Ory, Roberto Zoncu - Science 2017 cited by 589
- The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
Authors: Claire Goul, Roberta Peruzzo, Roberto Zoncu - Nature Reviews Molecular Cell Biology 2023 cited by 236
- ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C
Authors: Chun-Yan Lim, Oliver B. Davis, Hijai R. Shin, Zuopeng Zhang, Charles A. Berdan, Xuntian Jiang, Jessica L. Counihan, Daniel Ory, Daniel K. Nomura, Roberto Zoncu - Nature Cell Biology 2019 cited by 318
- Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
Authors: Shuyu Wang, Zhi-Yang Tsun, Rachel L. Wolfson, Kuang Shen, Gregory A. Wyant, Molly Plovanich, Elizabeth D. Yuan, Tony D. Jones, Lynne Chantranupong, William C. Comb, Timothy C. Wang, Liron Bar‐Peled, Roberto Zoncu, Christoph Straub, Choah Kim, Jiwon V. Park, Bernardo L. Sabatini, David M. Sabatini - 2015 cited by 823
- NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
Authors: Oliver B. Davis, Hijai R. Shin, Chun-Yan Lim, Emma Wu, Matthew A. Kukurugya, Claire Maher, Rushika M. Perera, M. Paulina Ordoñez, Roberto Zoncu - Developmental Cell 2020 cited by 201
- Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1
Authors: Hijai R. Shin, Y. Rose Citron, Lei Wang, Laura Tribouillard, Claire S. Goul, Robin Stipp, Yusuke Sugasawa, Aakriti Jain, Nolwenn Samson, Chun-Yan Lim, Oliver B. Davis, David Castaneda-Carpio, Mingxing Qian, Daniel K. Nomura, Rushika M. Perera, Eunyong Park, Douglas F. Covey, Mathieu Laplante, Alex S. Evers, Roberto Zoncu - Science 2022 cited by 132
- Emerging Roles for the Lysosome in Lipid Metabolism
Authors: Ashley Thelen, Roberto Zoncu - Trends in Cell Biology 2017 cited by 275
- Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
Authors: Liron Bar‐Peled, Lawrence D. Schweitzer, Roberto Zoncu, David M. Sabatini - Cell 2012 cited by 913
- Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness
Authors: Pekka Katajisto, Julia Döhla, Christine L. Chaffer, Nalle Pentinmikko, Nemanja D. Marjanovic, Sharif Iqbal, Roberto Zoncu, Walter W. Chen, Robert A. Weinberg, David M. Sabatini - Science 2015 cited by 559
- The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1
Authors: Zhi-Yang Tsun, Liron Bar‐Peled, Lynne Chantranupong, Roberto Zoncu, Timothy C. Wang, Choah Kim, Eric Spooner, David M. Sabatini - Molecular Cell 2013 cited by 545
- Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival
Authors: Alejo Efeyan, Roberto Zoncu, Steven H. Chang, Iwona Gumper, Harriet Snitkin, Rachel L. Wolfson, Oktay Kirak, David D. Sabatini, David M. Sabatini - Nature 2012 cited by 451
- Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition
Authors: Clive Yik‐Sham Chung, Hijai R. Shin, Charles A. Berdan, Breanna Ford, Carl C. Ward, James A. Olzmann, Roberto Zoncu, Daniel K. Nomura - Nature Chemical Biology 2019 cited by 185
- Built to last: lysosome remodeling and repair in health and disease
Authors: Roberto Zoncu, Rushika M. Perera - Trends in Cell Biology 2022 cited by 79
- Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex
Authors: Rosalie Lawrence, Simon A. Fromm, Yangxue Fu, Adam L. Yokom, Dojin Kim, Ashley Thelen, Lindsey N. Young, Chun-Yan Lim, Avi J. Samelson, James H. Hurley, Roberto Zoncu - Science 2019 cited by 180
- The lysosome as a command-and-control center for cellular metabolism
Authors: Chun-Yan Lim, Roberto Zoncu - The Journal of Cell Biology 2016 cited by 296
