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Setsuo Hirohashi

Active 1976–2010

150
Papers
27,648
Citations
103
h-index
150
i10-index

Citations

Citations per year for Setsuo Hirohashi1977: 1 citations1978: 2 citations1979: 1 citations1980: 1 citations1982: 1 citations1983: 2 citations1984: 3 citations1985: 3 citations1986: 2 citations1987: 5 citations1988: 8 citations1989: 11 citations1990: 22 citations1991: 18 citations1992: 52 citations1993: 83 citations1994: 104 citations1995: 81 citations1996: 92 citations1997: 87 citations1998: 115 citations1999: 154 citations2000: 186 citations2001: 227 citations2002: 257 citations2003: 268 citations2004: 273 citations2005: 304 citations2006: 323 citations2007: 313 citations2008: 354 citations2009: 312 citations2010: 350 citations2011: 339 citations2012: 313 citations2013: 283 citations2014: 253 citations2015: 227 citations2016: 208 citations2017: 210 citations2018: 141 citations2019: 492 citations2020: 512 citations2021: 456 citations2022: 256 citations2023: 193 citations2024: 257 citations2025: 102 citations2026: 3 citations1981: no citations, so this year is not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 2,507 citing papers, 26.4% of this breakdownJapan: 1,311 citing papers, 13.8% of this breakdownChina: 1,058 citing papers, 11.1% of this breakdownUnited Kingdom: 608 citing papers, 6.4% of this breakdownGermany: 484 citing papers, 5.1% of this breakdownItaly: 344 citing papers, 3.6% of this breakdownFrance: 323 citing papers, 3.4% of this breakdownSouth Korea: 277 citing papers, 2.9% of this breakdownSpain: 224 citing papers, 2.4% of this breakdownCanada: 220 citing papers, 2.3% of this breakdownAustralia: 166 citing papers, 1.7% of this breakdownNetherlands: 151 citing papers, 1.6% of this breakdown
0%26.4%Other 19.3%

Institutions

Fields

  • Medicine46.6%
  • Biochemistry, Genetics and Molecular Biology43.7%
  • Immunology and Microbiology4.5%
  • Neuroscience1.6%
  • Chemistry1.2%
  • Engineering0.4%
  • Other2%

Topics

  • Wnt/β-catenin signaling in development and cancer4.2%
  • Hepatocellular Carcinoma Treatment and Prognosis3.7%
  • Cancer-related gene regulation3.4%
  • Epigenetics and DNA Methylation3.2%
  • Genomics, phytochemicals, and oxidative stress2.5%
  • Cancer Cells and Metastasis2.2%
  • Other80.8%

Coauthors

All papers

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  1. Prevalence of FOXP3+ Regulatory T Cells Increases During the Progression of Pancreatic Ductal Adenocarcinoma and Its Premalignant Lesions

    Authors: Nobuyoshi Hiraoka, Kaoru Onozato, Tomoo Kosuge, Setsuo Hirohashi - Clinical Cancer Research 2006 cited by 822

  2. Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

    Authors: Tatsuhiro Shibata, Tsutomu Ohta, Kit I. Tong, Akiko Kokubu, Reiko Odogawa, Koji Tsuta, Hisao Asamura, Masayuki Yamamoto, Setsuo Hirohashi - National Academy of Sciences, Proceedings of the National Academy of Sciences 2008 cited by 721

  3. Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

    Authors: Tsutomu Ohta, Kumiko Iijima, Mamiko Miyamoto, Izumi Nakahara, Hiroshi Tanaka, Makiko Ohtsuji, Takafumi Suzuki, Akira Kobayashi, Jun Yokota, Tokuki Sakiyama, Tatsuhiro Shibata, Masayuki Yamamoto, Setsuo Hirohashi - Cancer Research 2008 cited by 628

  4. Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer

    Authors: Tatsuhiro Shibata, Akiko Kokubu, Masahiro Gotoh, Hidenori Ojima, Tsutomu Ohta, Masayuki Yamamoto, Setsuo Hirohashi - Gastroenterology 2008 cited by 472

  5. Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial

    Authors: Tadatoshi Takayama, Teruaki Sekine, Masatoshi Makuuchi, Susumu Yamasaki, Tomoo Kosuge, Junji Yamamoto, Kazuaki Shimada, Michiie Sakamoto, Setsuo Hirohashi, Yasuo Ohashi, Tadao Kakizoe - The Lancet 2000 cited by 848

  6. CXCL17 and ICAM2 Are Associated With a Potential Anti-Tumor Immune Response in Early Intraepithelial Stages of Human Pancreatic Carcinogenesis

    Authors: Nobuyoshi Hiraoka, Rie Yamazaki–Itoh, Yoshinori Ino, Yasunori Mizuguchi, Tesshi Yamada, Setsuo Hirohashi, Yae Kanai - Gastroenterology 2010 cited by 188

  7. Global Downstream Pathway Analysis Reveals a Dependence of Oncogenic NF-E2–Related Factor 2 Mutation on the mTOR Growth Signaling Pathway

    Authors: Tatsuhiro Shibata, Shigeru Saito, Akiko Kokubu, Takafumi Suzuki, Masayuki Yamamoto, Setsuo Hirohashi - Cancer Research 2010 cited by 127

  8. Small adenocarcinoma of the lung. Histologic characteristics and prognosis

    Authors: Masayuki Noguchi, Akio Morikawa, Masanori Kawasaki, Yoshihiro Matsuno, Tesshi Yamada, Setsuo Hirohashi, Haruhiko Kondoh, 下里 幸雄 - Cancer 1995 cited by 1,156

  9. Increased DNA Methyltransferase 1 (DNMT1) Protein Expression Correlates Significantly with Poorer Tumor Differentiation and Frequent DNA Hypermethylation of Multiple CpG Islands in Gastric Cancers

    Authors: Tsuyoshi Etoh, Yae Kanai, Saori Ushijima, Tohru Nakagawa, Yukihiro Nakanishi, Mitsuru Sasako, Seigo Kitano, Setsuo Hirohashi - American Journal Of Pathology 2004 cited by 291

  10. Actinin-4, a Novel Actin-bundling Protein Associated with Cell Motility and Cancer Invasion

    Authors: Kazufumi Honda, Tesshi Yamada, Ritsuko Endo, Yoshinori Ino, Masahiro Gotoh, Hitoshi Tsuda, Yozo Yamada, Hiroshige Chiba, Setsuo Hirohashi - The Journal of Cell Biology 1998 cited by 491

  11. FOXP3+ Regulatory T Cells Affect the Development and Progression of Hepatocarcinogenesis

    Authors: Noritoshi Kobayashi, Nobuyoshi Hiraoka, Wataru Yamagami, Hidenori Ojima, Yae Kanai, Tomoo Kosuge, Atsushi Nakajima, Setsuo Hirohashi - Clinical Cancer Research 2007 cited by 428

  12. Craniopharyngiomas of Adamantinomatous Type Harbor β-Catenin Gene Mutations

    Authors: Shigeki Sekine, Tatsuhiro Shibata, Akiko Kokubu, Yukio Morishita, Masayuki Noguchi, Yukihiro Nakanishi, Michiie Sakamoto, Setsuo Hirohashi - American Journal Of Pathology 2002 cited by 304

  13. Traf2- and Nck-Interacting Kinase Is Essential for Wnt Signaling and Colorectal Cancer Growth

    Authors: Miki Shitashige, Reiko Satow, Takafumi Jigami, Kazunori Aoki, Kazufumi Honda, Tatsuhiro Shibata, Masaya Ono, Setsuo Hirohashi, Tesshi Yamada - Cancer Research 2010 cited by 123

  14. Establishment of Perineural Invasion Models and Analysis of Gene Expression Revealed an Invariant Chain (CD74) as a Possible Molecule Involved in Perineural Invasion in Pancreatic Cancer

    Authors: Norimasa Koide, Taketo Yamada, Rie Shibata, Taisuke Mori, Mariko Fukuma, Ken Yamazaki, Koichi Aiura, Motohide Shimazu, Setsuo Hirohashi, Yuji Nimura, Michiie Sakamoto - Clinical Cancer Research 2006 cited by 112

  15. Cell adhesion system and human cancer morphogenesis

    Authors: Setsuo Hirohashi, Yae Kanai - Cancer Science 2003 cited by 442

  16. Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas

    Authors: Yoshimasa Saito, Yae Kanai, Tohru Nakagawa, Michiie Sakamoto, Hidetsugu Saito, Hiromasa Ishii, Setsuo Hirohashi - International Journal of Cancer 2003 cited by 252

  17. Cloning of the Novel Gene Intelectin, Which Is Expressed in Intestinal Paneth Cells in Mice

    Authors: Tohru Komiya, Yoko Tanigawa, Setsuo Hirohashi - Biochemical and Biophysical Research Communications 1998 cited by 201

  18. Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers

    Authors: Yae Kanai, Saori Ushijima, Yukihiro Nakanishi, Michiie Sakamoto, Setsuo Hirohashi - Cancer Letters 2003 cited by 140

  19. Prognostic Significance of CXCL12 Expression in Patients With Colorectal Carcinoma

    Authors: Yuri Akishima‐Fukasawa, Yukihiro Nakanishi, Yoshinori Ino, Yoshihiro Moriya, Yae Kanai, Setsuo Hirohashi - American Journal of Clinical Pathology 2009 cited by 84

  20. E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro

    Authors: Aimin Tang, Mark S. Eller, Masahiro Hara, Mina Yaar, Setsuo Hirohashi, Barbara A. Gilchrest - Journal of Cell Science 1994 cited by 296

  21. Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma

    Authors: Kazuaki Nakanishi, Michiie Sakamoto, Susumu Yamasaki, Satoru Todo, Setsuo Hirohashi - Cancer 2004 cited by 224

  22. Overexpression of Orphan G–Protein-Coupled Receptor, Gpr49 , in Human Hepatocellular Carcinomas With β–Catenin Mutations

    Authors: Yoshiya Yamamoto, Michiie Sakamoto, Gen Fujii, Hitomi Tsuiji, Kengo Kenetaka, Masahiro Asaka, Setsuo Hirohashi - Hepatology 2003 cited by 200

  23. Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis

    Authors: Yoshinori Ino, Masahiro Gotoh, Michiie Sakamoto, Kiyomi Tsukagoshi, Setsuo Hirohashi - National Academy of Sciences, Proceedings of the National Academy of Sciences 2001 cited by 176

  24. DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas

    Authors: Dunfa Peng, Yae Kanai, Morio Sawada, Saori Ushijima, Nobuyoshi Hiraoka, Sohei Kitazawa, Setsuo Hirohashi - Carcinogenesis 2006 cited by 151