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Thomas Helleday

Active 1999–2025

150
Papers
32,261
Citations
84
h-index
143
i10-index

Citations

Citations per year for Thomas Helleday1996: 1 citations1998: 2 citations2000: 2 citations2001: 6 citations2002: 9 citations2003: 26 citations2004: 31 citations2005: 87 citations2006: 114 citations2007: 152 citations2008: 181 citations2009: 205 citations2010: 384 citations2011: 363 citations2012: 424 citations2013: 454 citations2014: 450 citations2015: 535 citations2016: 568 citations2017: 514 citations2018: 427 citations2019: 1,285 citations2020: 1,532 citations2021: 1,403 citations2022: 1,059 citations2023: 740 citations2024: 1,144 citations2025: 536 citations2026: 17 citations1997: no citations, so this year is not shown1999: no citations, so this year is not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 3,923 citing papers, 26.5% of this breakdownChina: 1,541 citing papers, 10.4% of this breakdownUnited Kingdom: 1,510 citing papers, 10.2% of this breakdownGermany: 723 citing papers, 4.9% of this breakdownFrance: 579 citing papers, 3.9% of this breakdownItaly: 556 citing papers, 3.7% of this breakdownCanada: 524 citing papers, 3.5% of this breakdownSweden: 449 citing papers, 3% of this breakdownSpain: 433 citing papers, 2.9% of this breakdownNetherlands: 396 citing papers, 2.7% of this breakdownJapan: 385 citing papers, 2.6% of this breakdownSwitzerland: 309 citing papers, 2.1% of this breakdown
0%26.5%Other 23.6%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology54.6%
  • Medicine36.6%
  • Immunology and Microbiology3.7%
  • Computer Science1%
  • Chemistry0.9%
  • Neuroscience0.8%
  • Other2.4%

Topics

  • DNA Repair Mechanisms13.8%
  • PARP inhibition in cancer therapy8.7%
  • CRISPR and Genetic Engineering3.9%
  • Cancer-related Molecular Pathways2.8%
  • Epigenetics and DNA Methylation2.6%
  • Cancer Genomics and Diagnostics2.6%
  • Other65.6%

Coauthors

All papers

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  1. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

    Authors: Helen E. Bryant, Niklas Schultz, Huw D. Thomas, Kayan M. Parker, Dan Flower, Elena López‐Knowles, Suzanne Kyle, Mark Meuth, Nicola J. Curtin, Thomas Helleday - Nature 2005 cited by 5,221

  2. Spatially resolved clonal copy number alterations in benign and malignant tissue

    Authors: Andrew Erickson, Mengxiao He, Emelie Berglund, Maja Marklund, Reza Mirzazadeh, Niklas Schultz, Linda Kvastad, Alma Andersson, Ludvig Bergenstråhle, Joseph Bergenstråhle, Ludvig Larsson, Leire Alonso Galicia, Alia Shamikh, Elisa Basmaci, Teresita Díaz de Ståhl, Timothy Rajakumar, Dimitrios Doultsinos, Kim Thrane, Andrew L. Ji, Paul A. Khavari, Firaz Tarish, Anna Tanoglidi, Jonas Maaskola, Richard Colling, Tuomas Mirtti, Freddie C. Hamdy, Dan J. Woodcock, Thomas Helleday, Ian G. Mills, Alastair Lamb, Joakim Lundeberg - Nature 2022 cited by 318

  3. Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity

    Authors: Emelie Berglund, Jonas Maaskola, Niklas Schultz, Stefanie Friedrich, Maja Marklund, Joseph Bergenstråhle, Firas Tarish, Anna Tanoglidi, Sanja Vicković, Ludvig Larsson, Fredrik Salmén, Christoph Ogris, Karolina Wallenborg, Jens Lagergren, Patrik L. Ståhl, Erik L. L. Sonnhammer, Thomas Helleday, Joakim Lundeberg - Nature Communications 2018 cited by 619

  4. Replication stress links structural and numerical cancer chromosomal instability

    Authors: Rebecca A. Burrell, Sarah E. McClelland, David Endesfelder, Petra Groth, Marie-Christine Weller, Nadeem Shaikh, Enric Domingo, Nnennaya Kanu, Sally M. Dewhurst, Eva Grönroos, Su Kit Chew, Andrew Rowan, Arne Schenk, Michal Sheffer, Michael Howell, Maik Kschischo, Axel Behrens, Thomas Helleday, Jiří Bártek, Ian Tomlinson, Charles Swanton - Nature 2013 cited by 921

  5. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

    Authors: Jiřina Bártková, Nousin Rezaei, Michalis Liontos, Panagiotis Karakaidos, Dimitris Kletsas, Natalia Issaeva, Leandros-Vassilios Vassiliou, Evangelos Kolettas, Katerina Niforou, Vassilis Zoumpourlis, Munenori Takaoka, Hiroshi Nakagawa, Frederic Tort, Kasper Fugger, Fredrik Johansson, Maxwell Sehested, Claus L. Andersen, Lars Dyrskjøt, Torben Ørntoft, Jiri Lukas, Christos Kittas, Thomas Helleday, Thanos D. Halazonetis, Jiří Bártek, Vassilis G. Gorgoulis - Nature 2006 cited by 1,980

  6. DNA repair pathways as targets for cancer therapy

    Authors: Thomas Helleday, Eva Petermann, Cecilia Lundin, Ben Hodgson, Ricky A. Sharma - Nature reviews. Cancer 2008 cited by 1,678

  7. The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings

    Authors: Thomas Helleday - Molecular Oncology 2011 cited by 847

  8. Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer

    Authors: Charlotte Thålin, Staffan Lundström, Cédric Seignez, Maud Daleskog, Annika Lundström, Peter Henriksson, Thomas Helleday, Mia Phillipson, Håkan Wallén, Mélanie Demers - PLoS ONE 2018 cited by 219

  9. Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer

    Authors: Mohammad Asim, Firas Tarish, Heather Zecchini, Kumar Sanjiv, Eleni Gelali, Charles Massie, Ajoeb Baridi, Anne Y. Warren, Wanfeng Zhao, Christoph Ogris, Leigh‐Anne McDuffus, Patrice Mascalchi, Greg Shaw, Harveer Dev, Karan Wadhwa, Paul W.G. Wijnhoven, Josep V. Forment, Scott R. Lyons, Andy G. Lynch, Cormac O’Neill, Vincent Zecchini, Paul S. Rennie, Aria Baniahmad, Simon Tavaré, Ian G. Mills, Yaron Galanty, Nicola Crosetto, Niklas Schultz, David E. Neal, Thomas Helleday - Nature Communications 2017 cited by 278

  10. Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells

    Authors: Lorenzo Costantino, Sotirios K. Sotiriou, Juha Rantala, Simon Magin, Emil Mladenov, Thomas Helleday, James E. Haber, George Iliakis, Olli Kallioniemi, Thanos D. Halazonetis - Science 2013 cited by 448

  11. Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model

    Authors: Lloyd Tanner, Andrew Single, Ravi K. V. Bhongir, Moritz Heusel, Tirthankar Mohanty, Christofer Karlsson, Lang Pan, C.-M. Clausson, Jesper Bergwik, K. Wang, Cecilia Andersson, R. M. Oommen, Jonas S. Erjefält, Johan Malmström, Olov Wallner, István Boldogh, Thomas Helleday, Christina Kalderén, Arne Egesten - Nature Communications 2023 cited by 105

  12. Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

    Authors: Eva Petermann, Manuel Luís Orta, Natalia Issaeva, Niklas Schultz, Thomas Helleday - Molecular Cell 2010 cited by 832

  13. PARP is activated at stalled forks to mediate Mre11‐dependent replication restart and recombination

    Authors: Helen E. Bryant, Eva Petermann, Niklas Schultz, Ann‐Sofie Jemth, Olga Loseva, Natalia Issaeva, Fredrik Johansson, Serena Fernandez, Peter McGlynn, Thomas Helleday - The EMBO Journal 2009 cited by 596

  14. Mechanisms underlying mutational signatures in human cancers

    Authors: Thomas Helleday, Saeed Eshtad, Serena Nik‐Zainal - Nature Reviews Genetics 2014 cited by 877

  15. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

    Authors: Helge Gad, Tobias Koolmeister, Ann‐Sofie Jemth, Saeed Eshtad, Sylvain A. Jacques, Cecilia Ström, L. Svensson, Niklas Schultz, Thomas Lundbäck, Berglind O. Einarsdottir, Aljona Saleh, Camilla Göktürk, Paweł Baranczewski, Richard Svensson, Ronnie P.‐A. Berntsson, Robert Gustafsson, Kia Strömberg, Kumar Sanjiv, Marie‐Caroline Jacques‐Cordonnier, Matthieu Desroses, Anna‐Lena Gustavsson, Roger Olofsson Bagge, Fredrik Johansson, Evert Homan, Olga Loseva, Lars Bräutigam, L. E. B. Johansson, Andreas Höglund, Anna Hagenkort, Therese Pham, Mikael Altun, Fabienne Z. Gaugaz, Svante Vikingsson, Bastiaan Evers, Martin Henriksson, Karl S. A. Vallin, Olov Wallner, Lars G.J. Hammarström, Elisée Wiita, Ingrid Almlöf, Christina Kalderén, Hanna Axelsson, Tatjana Djureinovic, Jordi Carreras‐Puigvert, Maria Häggblad, Fredrik Jeppsson, Ulf Märtens, Cecilia Lundin, Bo Lundgren, Ingrid Granelli, Annika Jenmalm Jensen, Per Artursson, Jonas A. Nilsson, Pål Stenmark, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday - Nature 2014 cited by 529

  16. Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

    Authors: Torkild Visnes, Armando Cázares‐Körner, Wenjing Hao, Olov Wallner, Geoffrey Masuyer, Olga Loseva, Oliver Mortusewicz, Elisée Wiita, Antonio Sarno, Aleksandr Manoilov, Juan Astorga‐Wells, Ann‐Sofie Jemth, Lang Pan, Kumar Sanjiv, Stella Karsten, Camilla Göktürk, Maurice Grube, Evert Homan, Bishoy Hanna, Cynthia B. J. Paulin, Therese Pham, Azita Rasti, Ulrika Warpman Berglund, Catharina Von Nicolai, Carlos Benitéz‐Buelga, Tobias Koolmeister, Dag Ivanic, Petar Iliev, Martin Scobie, Hans E. Krokan, Paweł Baranczewski, Per Artursson, Mikael Altun, Annika Jenmalm Jensen, Christina Kalderén, Xueqing Ba, Roman A. Zubarev, Pål Stenmark, István Boldogh, Thomas Helleday - Science 2018 cited by 233

  17. SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

    Authors: Sophia X. Pfister, Sara Ahrabi, Lykourgos‐Panagiotis Zalmas, Sovan Sarkar, François Aymard, Csanád Z. Bachrati, Thomas Helleday, Gaëlle Legube, Nicholas B. La Thangue, Andrew C.G. Porter, Timothy C. Humphrey - Cell Reports 2014 cited by 460

  18. Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function

    Authors: Maurice Michel, Carlos Benitéz‐Buelga, Patricia A. Calvo, Bishoy Hanna, Oliver Mortusewicz, Geoffrey Masuyer, Jonathan Davies, Olov Wallner, Kumar Sanjiv, Julian J. Albers, Sergio Castañeda‐Zegarra, Ann‐Sofie Jemth, Torkild Visnes, Ana Sastre-Perona, Akhilesh Nagesh Danda, Evert Homan, Karthick Marimuthu, Zhao Zhenjun, N. Celestine, Antonio Sarno, Elisée Wiita, Catharina Von Nicolai, Anna J. Komor, Varshni Rajagopal, Sarah Müller, Emily C. Hank, Marek Varga, Emma Rose Scaletti, Monica Pandey, Stella Karsten, Hanne Haslene‐Hox, Simon Loevenich, Petra Marttila, Azita Rasti, Kirill Mamonov, Florian Ortis, Fritz Schömberg, Olga Loseva, Josephine Stewart, Nicholas D’Arcy-Evans, Tobias Koolmeister, Martin Henriksson, Dana Michel, Ana de Ory, Lucía Acero-Riaguas, Oriol Calvete, Martin Scobie, Christian Hertweck, Ivan Vilotijević, Christina Kalderén, Ana Osório, Rosario Perona, Alexandra Stolz, Pål Stenmark, Ulrika Warpman Berglund, Miguel de Vega, Thomas Helleday - Science 2022 cited by 75

  19. Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress

    Authors: Rebecca M. Jones, Oliver Mortusewicz, Irfan Afzal, Maëlle Lorvellec, Paloma García, Thomas Helleday, Eva Petermann - Oncogene 2012 cited by 293

  20. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

    Authors: Brent D. G. Page, Nicholas C.K. Valerie, Roni H. G. Wright, Olov Wallner, Rebecka Isaksson, Megan Carter, Sean G. Rudd, Olga Loseva, Ann‐Sofie Jemth, Ingrid Almlöf, Jofre Font-Mateu, Sabin Llona‐Minguez, Paweł Baranczewski, Fredrik Jeppsson, Evert Homan, Helena Almqvist, Hanna Axelsson, Shruti Regmi, Anna‐Lena Gustavsson, Thomas Lundbäck, Martin Scobie, Kia Strömberg, Pål Stenmark, Miguel Beato, Thomas Helleday - Nature Communications 2018 cited by 124

  21. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

    Authors: K. Huber, E. Salah, Branka Radic-Sarikas, Manuela Gridling, Jonathan M. Elkins, Alexey Stukalov, Ann‐Sofie Jemth, Camilla Göktürk, Kumar Sanjiv, Kia Strömberg, Therese Pham, Ulrika Warpman Berglund, Jacques Colinge, Keiryn L. Bennett, Joanna I. Loizou, Thomas Helleday, Stefan Knapp, Giulio Superti‐Furga - Nature 2014 cited by 390

  22. Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

    Authors: Nadilly Bonagas, Nina Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay R. Borhade, Alanna C. Green, Karl S. A. Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann‐Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith E. Unterlass, Martin Haraldsson, Yasmin Andersson, Emma Rose Scaletti, Christoffer Bengtsson, Cynthia B. J. Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Märtens, Sabin Llona‐Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene Lisa Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans E. Krokan, Per I. Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert Homan, Thomas Helleday - Nature Cancer 2022 cited by 105

  23. Mechanisms for stalled replication fork stabilization: new targets for synthetic lethality strategies in cancer treatments

    Authors: Hongwei Liao, Fang Ji, Thomas Helleday, Songmin Ying - EMBO Reports 2018 cited by 185

  24. Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

    Authors: Nina Gustafsson, Katarina Färnegårdh, Nadilly Bonagas, Anna Huguet Ninou, Petra Groth, Elisée Wiita, Mattias Jönsson, Kenth Hallberg, Jemina Lehto, Rosa Pennisi, Jessica Martinsson, Carina Norström, Jessica Hollers, Johan Schultz, Martin Andersson, Natalia Markova, Petra Marttila, Baek Kim, Martin Norin, Thomas Olin, Thomas Helleday - Nature Communications 2018 cited by 131