Timothy W. Schacker
Active 1996–2025
- 86
- Papers
- 22,257
- Citations
- 67
- h-index
- 83
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Immunology and Microbiology57.6%
- Medicine31.7%
- Biochemistry, Genetics and Molecular Biology7.4%
- Neuroscience1.2%
- Agricultural and Biological Sciences0.4%
- Computer Science0.2%
- Other1.5%
Topics
- HIV Research and Treatment18.9%
- Immune Cell Function and Interaction10.7%
- HIV/AIDS Research and Interventions7.1%
- T-cell and B-cell Immunology5.2%
- HIV/AIDS drug development and treatment5.1%
- HIV-related health complications and treatments4.3%
- Other48.7%
Coauthors
- Ashley T. Haase29
- Cavan Reilly16
- Daniel C. Douek16
- Gregory J. Beilman16
- Lawrence Corey16
- Jeffrey G. Chipman15
- Jodi Anderson13
- Jacob D. Estes12
- Courtney V. Fletcher11
- Stephen W. Wietgrefe10
- Jason M. Brenchley9
- Alexander Khoruts8
- Peter J. Southern8
- Steven G. Deeks8
- Ann Thorkelson6
- Benigno Rodríguez6
- Christopher J. Tignanelli6
- John V. Carlis6
- Joseph K. Wong6
- Michael M. Lederman6
- David A. Price5
- Douglas D. Richman5
- Jason V. Baker5
- Jeffrey D. Lifson5
All papers
- HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
Authors: Nicolas Chomont, Mohamed El‐Far, Petronela Ancuța, Lydie Trautmann, Francesco A. Procopio, Bader Yassine‐Diab, Geneviève Boucher, Mohamed‐Rachid Boulassel, Georges Ghattas, Jason M. Brenchley, Timothy W. Schacker, Brenna J. Hill, Daniel C. Douek, Jean‐Pierre Routy, Elias K. Haddad, Rafick‐Pierre Sékaly - Nature Medicine 2009 cited by 1,730
- Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Authors: Jason M. Brenchley, David A. Price, Timothy W. Schacker, Tedi E. Asher, Guido Silvestri, Srinivas S. Rao, Zachary Kazzaz, Ethan Bornstein, Olivier Lambotte, Daniel M. Altmann, Bruce R. Blazar, Benigno Rodríguez, Leia Teixeira-Johnson, Alan Landay, Jeffrey N. Martin, Frederick Hecht, Louis J. Picker, Michael M. Lederman, Steven G. Deeks, Daniel C. Douek - Nature Medicine 2006 cited by 3,542
- CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles
Authors: Kevin Man, Yunbo Wei, Sharon R. Lewin, Anurag Atnerkar, Iain Comerford, Claire Deléage, Peng Wang, Yu, Di, Dimitra Zotos, Yaping Chen, Jiawei Xu, Shaun R. McColl, Jeffrey G. Chipman, Lei Sun, Zhaohua Hou, Simon Preston, Martina Minnich, Gabrielle T. Belz, Cody C. Allison, Hong Sheng Ong, Jacob D. Estes, Axel Kallies, Hao Lu, Alan Landay, Umaimainthan Palendira, Gregory J. Beilman, Benjamin J. Meckiff, Timothy W. Schacker, Kevin Fenix, Alexander L. Dent, Di Wu, Marc Pellegrini, Yew Ann Leong, Heather M. Long, Jesse G. Toe, Yong Tao, Meinrad Busslinger - Nature Immunology 2016 cited by 485
- Defining total-body AIDS-virus burden with implications for curative strategies
Authors: Jacob D. Estes, Cissy Kityo, Francis Ssali, Louise Swainson, Krystelle Nganou Makamdop, Gregory Q. Del Prete, Steven G. Deeks, Paul A. Luciw, Jeffrey G. Chipman, Gregory J. Beilman, Torfi Hoskuldsson, Alexander Khoruts, Jodi Anderson, Claire Deléage, Jacob Jasurda, Thomas Schmidt, Michael Hafertepe, Samuel P. Callisto, Hope Pearson, Thomas Reimann, Jared Schuster, Jordan Schoephoerster, Peter J. Southern, Katherine Perkey, Liang Shang, Stephen W. Wietgrefe, Courtney V. Fletcher, Jeffrey D. Lifson, Daniel C. Douek, Joseph M. McCune, Ashley T. Haase, Timothy W. Schacker - Nature Medicine 2017 cited by 416
- Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues
Authors: Courtney V. Fletcher, K A Staskus, Stephen W. Wietgrefe, Meghan Rothenberger, Cavan Reilly, Jeffrey G. Chipman, Gregory J. Beilman, Alexander Khoruts, Ann Thorkelson, Thomas Schmidt, Jodi Anderson, Katherine Perkey, Mario Stevenson, Alan S. Perelson, Daniel C. Douek, Ashley T. Haase, Timothy W. Schacker - National Academy of Sciences, Proceedings of the National Academy of Sciences 2014 cited by 655
- Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a phase 1 trial
Authors: Jeffrey S. Miller, Zachary Davis, Erika S. Helgeson, Cavan Reilly, Ann Thorkelson, Jodi Anderson, Noemia S. Lima, Siri Jorstad, Geoffrey T. Hart, John H Lee, Jeffrey T. Safrit, Hing C. Wong, Sarah Cooley, Lavina Gharu, Hyunsoo Chung, Patrick Soon‐Shiong, Curtis Dobrowolski, Courtney V. Fletcher, Jonathan Karn, Daniel C. Douek, Timothy W. Schacker - Nature Medicine 2022 cited by 107
- CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract
Authors: Jason M. Brenchley, Timothy W. Schacker, Laura E. Ruff, David A. Price, Jodie H. Taylor, Gregory J. Beilman, Phuong L. Nguyen, Alexander Khoruts, Matthew Larson, Ashley T. Haase, Daniel C. Douek - The Journal of Experimental Medicine 2004 cited by 1,818
- Persistent HIV-1 replication maintains the tissue reservoir during therapy
Authors: Ramón Lorenzo-Redondo, Helen Fryer, Trevor Bedford, Eun‐Young Kim, John Archer, Sergei L. Kosakovsky Pond, Yoon‐Seok Chung, Sudhir Penugonda, Jeffrey G. Chipman, Courtney V. Fletcher, Timothy W. Schacker, Michael H. Malim, Andrew Rambaut, Ashley T. Haase, Angela R. McLean, Steven M. Wolinsky - Nature 2016 cited by 631
- Recommendations for analytical antiretroviral treatment interruptions in HIV research trials—report of a consensus meeting
Authors: Boris Jülg, Lynda Dee, Jintanat Ananworanich, Dan H. Barouch, Katharine J. Bar, Marina Caskey, Donn Colby, Liza Dawson, Krista L. Dong, Karine Dubé, Joseph J. Eron, John Frater, Rajesh T. Gandhi, Romas Geleziunas, Philip Goulder, George J. Hanna, Richard Jefferys, Rowena Johnston, Daniel R. Kuritzkes, Jonathan Z. Li, Udom Likhitwonnawut, Jan van Lunzen, Javier Martínez‐Picado, Veronica Miller, Luis J. Montaner, Douglas F. Nixon, David Palm, Giuseppe Pantaleo, Holly L. Peay, Deborah Persaud, Jessica Salzwedel, Karl Salzwedel, Timothy W. Schacker, Virginia Sheikh, Ole S. Søgaard, Serena Spudich, Kathryn E. Stephenson, Jeremy Sugarman, Jeff Taylor, Pablo Tebas, Caroline T. Tiemessen, Randall Tressler, Carol D. Weiss, Lu Zheng, Merlin L. Robb, Nelson L. Michael, John W. Mellors, Steven G. Deeks, Bruce D. Walker - The Lancet HIV 2019 cited by 206
- High-affinity memory B cells induced by SARS-CoV-2 infection produce more plasmablasts and atypical memory B cells than those primed by mRNA vaccines
Authors: Kathryn A. Pape, Thamotharampillai Dileepan, Amanda J. Kabage, Daria Kozysa, Rodolfo Batres, Clayton Evert, Michael Matson, Sharon Lopez, P. Krueger, Carolyn Graiziger, Byron P. Vaughn, Eugenia Shmidt, Joshua Rhein, Timothy W. Schacker, Alexander Khoruts, Marc K. Jenkins - Cell Reports 2021 cited by 112
- PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
Authors: Constantinos Petrovas, Joseph P. Casazza, Jason M. Brenchley, David A. Price, Emma Gostick, William C. Adams, Melissa Precopio, Timothy W. Schacker, Mario Roederer, Daniel C. Douek, Richard A. Koup - The Journal of Experimental Medicine 2006 cited by 875
- Defining HIV and SIV Reservoirs in Lymphoid Tissues
Authors: Claire Deléage, Stephen W. Wietgrefe, Gregory Q. Del Prete, David R. Morcock, Xingpei Hao, Michael Piatak, Julian W. Bess, Jodi Anderson, Katherine Perkey, Cavan Reilly, Joseph M. McCune, Ashley T. Haase, Jeffrey D. Lifson, Timothy W. Schacker, Jacob D. Estes - Pathogens and Immunity 2016 cited by 262
- Translocated microbiome composition determines immunological outcome in treated HIV infection
Authors: Krystelle Nganou‐Makamdop, Aarthi Talla, Ashish Sharma, Samuel Darko, Amy Ransier, Farida Laboune, Jeffrey G. Chipman, Gregory J. Beilman, Torfi Hoskuldsson, Slim Fourati, Thomas Schmidt, Sahaana Arumugam, Noemia S. Lima, Damee Moon, Samuel P. Callisto, Jordan Schoephoerster, Jeffery Tomalka, Peter Mugyenyi, Francis Ssali, Proscovia Muloma, Patrick Ssengendo, Ana Rachel Léda, Ryan K. Cheu, Jacob K. Flynn, Antigoni Morou, Elsa Brunet‐Ratnasingham, Benigno Rodríguez, Michael M. Lederman, Daniel E. Kaufmann, Nichole R. Klatt, Cissy Kityo, Jason M. Brenchley, Timothy W. Schacker, Rafick‐Pierre Sékaly, Daniel C. Douek - Cell 2021 cited by 80
- Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption
Authors: Meghan Rothenberger, Brandon F. Keele, Stephen W. Wietgrefe, Courtney V. Fletcher, Gregory J. Beilman, Jeffrey G. Chipman, Alexander Khoruts, Jacob D. Estes, Jodi Anderson, Samuel P. Callisto, Thomas Schmidt, Ann Thorkelson, Cavan Reilly, Katherine Perkey, Thomas Reimann, Netanya S. Utay, Krystelle Nganou Makamdop, Mario Stevenson, Daniel C. Douek, Ashley T. Haase, Timothy W. Schacker - National Academy of Sciences, Proceedings of the National Academy of Sciences 2015 cited by 278
- IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection
Authors: Souheil-Antoine Younes, Michael L. Freeman, Joseph C. Mudd, Carey L. Shive, Arnold Reynaldi, Soumya Panigrahi, Jacob D. Estes, Claire Deléage, Carissa M. Lucero, Jodi Anderson, Timothy W. Schacker, Miles P. Davenport, Joseph M. McCune, Peter W. Hunt, Sulggi A. Lee, Sergio Serrano‐Villar, Robert Debernardo, Jeffrey M. Jacobson, David H. Canaday, Rafick‐Pierre Sékaly, Benigno Rodríguez, Scott F. Sieg, Michael M. Lederman - Journal of Clinical Investigation 2016 cited by 120
- Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection
Authors: Louise Leyre, Eugène Kroon, Claire Vandergeeten, Carlo Sacdalan, Donn Colby, Supranee Buranapraditkun, Alexandra Schuetz, Nitiya Chomchey, Mark de Souza, Wendy Bakeman, Rémi Fromentin, Suteeraporn Pinyakorn, Siriwat Akapirat, Rapee Trichavaroj, Suthat Chottanapund, Sopark Manasnayakorn, Rungsun Rerknimitr, Phandee Wattanaboonyoungcharoen, Jérôme H. Kim, Sodsai Tovanabutra, Timothy W. Schacker, Robert J. O’Connell, Victor Valcour, Praphan Phanuphak, Merlin L. Robb, Nelson L. Michael, Lydie Trautmann, Nittaya Phanuphak, Jintanat Ananworanich, Nicolas Chomont, on behalf of the RV254/SEARCH010, RV304/SEARCH013, SEARCH011 study groups - Science Translational Medicine 2020 cited by 108
- Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient
Authors: Steven A. Yukl, Eli Boritz, Michael P. Busch, Christopher Bentsen, Tae‐Wook Chun, Daniel C. Douek, Evelyn E. Eisele, Ashley T. Haase, Ya‐Chi Ho, Gero Hütter, J. Shawn Justement, Sheila M. Keating, Tzong‐Hae Lee, Peilin Li, Danielle Murray, Sarah Palmer, Christopher D. Pilcher, Satish K. Pillai, Richard W. Price, Meghan Rothenberger, Timothy W. Schacker, Janet D. Siliciano, Robert F. Siliciano, Elizabeth Sinclair, Matt C. Strain, Joseph K. Wong, Douglas D. Richman, Steven G. Deeks - PLoS Pathogens 2013 cited by 290
- Multiple Origins of Virus Persistence during Natural Control of HIV Infection
Authors: Eli Boritz, Samuel Darko, Luke Swaszek, Gideon Wolf, David W. Wells, Xiaolin Wu, Amy R. Henry, Farida Laboune, Jianfei Hu, David R. Ambrozak, Marybeth S. Hughes, Rebecca Hoh, Joseph P. Casazza, Alexander Vostal, Daniel Bunis, Krystelle Nganou‐Makamdop, James Lee, Stephen A. Migueles, Richard A. Koup, Mark Connors, Susan Moir, Timothy W. Schacker, Frank Maldarelli, Stephen H. Hughes, Steven G. Deeks, Daniel C. Douek - Cell 2016 cited by 183
- Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections
Authors: Jason M. Brenchley, Mirko Paiardini, Kenneth S. Knox, Ava I. Asher, Barbara Cervasi, Tedi E. Asher, Phillip Scheinberg, David A. Price, Chadi A. Hage, Lisa M. Kholi, Alexander Khoruts, Ian Frank, James G. Else, Timothy W. Schacker, Guido Silvestri, Daniel C. Douek - Blood 2008 cited by 634
- Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production
Authors: Jing Du, Katelyn Paz, Ryan Flynn, Ante Vulic, Tara M. Robinson, Katie E. Lineburg, Kylie A. Alexander, Jingjing Meng, Sabita Roy, Angela Panoskaltsis‐Mortari, Michaël Loschi, Geoffrey R. Hill, Jonathan S. Serody, Ivan Maillard, David B. Miklos, John Koreth, Corey Cutler, Joseph H. Antin, Jerome Ritz, Kelli P. A. MacDonald, Timothy W. Schacker, Leo Luznik, Bruce R. Blazar - Blood 2017 cited by 156
- Time to HIV viral rebound and frequency of post-treatment control after analytical interruption of antiretroviral therapy: an individual data-based meta-analysis of 24 prospective studies
Authors: Jesper Damsgaard Gunst, Jesal Gohil, Jonathan Z. Li, Ronald J. Bosch, Caitlin White, Tae‐Wook Chun, Beatriz Mothe, Kathleen Gittens, Lauren Praiss, Marie‐Angélique De Scheerder, Linos Vandekerckhove, Kevin Escandón-Vargas, Ann Thorkelson, Timothy W. Schacker, Devi SenGupta, Christian Brander, Emmanouil Papasavvas, Luis J. Montaner, Javier Martínez‐Picado, Ruxandra Câlin, Antonella Castagna, Camilla Muccini, Wesley de Jong, Lorna Leal, Felipe García, Rob A. Gruters, Timothy Tipoe, John Frater, Ole S. Søgaard, Sarah Fidler - Nature Communications 2025 cited by 52
- Interferon-α Is the Primary Plasma Type-I IFN in HIV-1 Infection and Correlates with Immune Activation and Disease Markers
Authors: Gareth Hardy, Scott F. Sieg, Benigno Rodríguez, Donald D. Anthony, Robert Asaad, Wei Jiang, Joseph C. Mudd, Timothy W. Schacker, Nicholas Funderburg, Heather A. Pilch-Cooper, Robert Debernardo, Ronald L. Rabin, Michael M. Lederman, Clifford V. Harding - PLoS ONE 2013 cited by 167
- Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections
Authors: Ming Zeng, Anthony J. Smith, Stephen W. Wietgrefe, Peter J. Southern, Timothy W. Schacker, Cavan Reilly, Jacob D. Estes, Gregory F. Burton, Guido Silvestri, Jeffrey D. Lifson, John V. Carlis, Ashley T. Haase - Journal of Clinical Investigation 2011 cited by 304
- Lymphoid Tissue Damage in HIV-1 Infection Depletes Naïve T Cells and Limits T Cell Reconstitution after Antiretroviral Therapy
Authors: Ming Zeng, Peter J. Southern, Cavan Reilly, Gregory J. Beilman, Jeffrey G. Chipman, Timothy W. Schacker, Ashley T. Haase - PLoS Pathogens 2012 cited by 176
