Left Atrial Appendage Closure after Ablation for Atrial Fibrillation

Authors: Oussama Wazni, Walid I. Saliba, Devi G. Nair, Éloi Marijon, Boris Schmidt, Troy Hounshell, Henning Ebelt, Carsten Skurk, Saumil R. Oza, Chinmay Patel, Arvindh N. Kanagasundram, Ashish Sadhu, Sri Sundaram, José Osorio, George E. Mark, Madhukar Gupta, David B. DeLurgio, Jeffrey J. Olson, Jens Erik Nielsen‐Kudsk, Lucas V.A. Boersma, Jeff S. Healey, K. Phillips, Federico M. Asch, Katherine E. Wolski, Kristine Roy, Thomas Christen, Brad Sutton, Kenneth M. Steín, Vivek Y. Reddy - New England Journal of Medicine, NEJM 2024 cited by 167

BACKGROUND: Oral anticoagulation is recommended after ablation for atrial fibrillation among patients at high risk for stroke. Left atrial appendage closure is a mechanical alternative to anticoagulation, but data regarding its use after atrial fibrillation ablation are lacking. METHODS: -VASc scale (range, 0 to 9, with higher scores indicating a greater risk of stroke) and who underwent catheter ablation. Patients were randomly assigned in a 1:1 ratio to undergo left atrial appendage closure or receive oral anticoagulation. The primary safety end point, tested for superiority, was non-procedure-related major bleeding or clinically relevant nonmajor bleeding. The primary efficacy end point, tested for noninferiority, was a composite of death from any cause, stroke, or systemic embolism at 36 months. The secondary end point, tested for noninferiority, was major bleeding, including procedure-related bleeding, through 36 months. RESULTS: -VASc score was 3.5±1.3. At 36 months, a primary safety end-point event had occurred in 65 patients (8.5%) in the left atrial appendage closure group (device group) and in 137 patients (18.1%) in the anticoagulation group (P<0.001 for superiority); a primary efficacy end-point event had occurred in 41 patients (5.3%) and 44 patients (5.8%), respectively (P<0.001 for noninferiority); and a secondary end-point event had occurred in 3.9% and 5.0% (P<0.001 for noninferiority). Complications related to the appendage closure device or procedure occurred in 23 patients. CONCLUSIONS: Among patients who underwent catheter-based atrial fibrillation ablation, left atrial appendage closure was associated with a lower risk of non-procedure-related major or clinically relevant nonmajor bleeding than oral anticoagulation and was noninferior to oral anticoagulation with respect to a composite of death from any cause, stroke, or systemic embolism at 36 months. (Funded by Boston Scientific; OPTION ClinicalTrials.gov number, NCT03795298.).