Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage

Authors: Michael H. Askenase, Brittany A. Goods, Hannah E. Beatty, Arthur F. Steinschneider, Sofia Velazquez, Artem Osherov, Margaret Landreneau, Shaina L. Carroll, Tho B. Tran, Victor Avram, Riley S. Drake, G. James Gatter, Jordan Massey, Saravanan S. Karuppagounder, Rajiv R. Ratan, Charles Matouk, Kevin N. Sheth, Wendy Ziai, Adrian Parry‐Jones, Issam A. Awad, Mario Zuccarello, Richard E. Thompson, Jesse Dawson, Daniel F. Hanley, J. Christopher Love, Alex K. Shalek, Lauren Sansing, ICHseq investigators, ICHseq Investigators, Steven J. Barrer, Larami MacKenzie, Karin Jonczak, Patricia Bussinger, Peter Nakaji, Shawn E. Wright, Norissa Honea, Ali Zomorodi, Michael L. James, Erlinda Yeh, Walter Galicich, Thomas Bergman, Kathryn A. France, James Leiphart, Swathi Ramesh, Tricia Brennan, Judy Huang, Wendy Ziai, Mirinda Anderson White, Paul J. Camarata, Michael Abraham, Jason Gorup, Ronald Reimer, William D. Freeman, Cristin Williams, Emily Edwards, Ania Pollack, John Terry, Angela Shoen, Babak S. Jahromi, Matthew B. Maas, Byron Yip, Christina Amidei, Lorenzo Muñoz, George Α. Lopez, Rebecca Holtz, Gaurav Gupta, Igor Rybinnik, Michelle Moccio, Darren Lovick, B Brion, Kelsey Titus, Jack Jallo, Fred Rincón, Kara Pigott, Laura Boyden, Jaime Dougherty, Mark R. Harrigan, David Miller, Lisa Nelson, Gregory Thompson, Ventatakrishna Rajajee, Aditya Pandey, Ron O. Ball, Andrew P. Carlson, Huy Tran, Amal Alchbli, Robert F. James, Ann Jerde, Philipp Taussky, Safdar Ansari, Crystal Neate, Julie Kay Martinez, Joshua Letsinger, Lilly Fagatele, Carol Eaquinto, Charles Matouk, Kevin N. Sheth, Lauren Sansing, Linda Ryall, Kimberly Kunze, David Mampre, Sara Jasak, MISTIE III Investigators, Azmil H. Abdul‐Rahim, Amal Abou‐Hamden, Michael Abraham, Azam Ahmed, Carlos Alarcon Alba, E. François Aldrich, Hasan Ali, David Altschul, Sepideh Amin‐Hanjani, Craig S. Anderson, Doug Anderson, Safdar Ansari, David Antezana, Agnieszka Ardelt, Fuat Arikán, Radhika Awad, M. Báguena, Alexandra Baker, Steven J. Barrer, Pál Barzó, Kyra J. Becker, Thomas Bergman, Joshua Betz, Amanda J. Bistran-Hall, Azize Boström, Jamie Braun, Peter G. Brindley, William C. Broaddus, R. Dale Brown, András Büki, Diederik Bulters, Paul J. Camarata, Bing Cao, Ying Cao, J. Ricardo Carhuapoma, Andrew P. Carlson, Jean-Louis Caron, Julián Carrión‐Penagos, Julio A. Chalela, Tiffany Chang, Michael R. Chicoine, Indalecio Moran Chorro, Shakeel Chowdhry, Cully A. Cobb, Luisa Corral, László Csiba, Jason M. Davies, Jesse Dawson, Alberto Torres Díaz, Colin P. Derdeyn, Michael N. Diringer, Rachel Dlugash, Robert Dodd, Robert D. Ecker, Tracey Economas, Pedro Enríquez, Erzsébet Ezer, Yuhua Fan, Hua Feng, Douglas Franz, William D. Freeman, Matthew R. Fusco, Walter Galicich, Dheeraj Gandhi, Mary Leigh Gelea, Joshua N. Goldstein, Alejandro Carrasco Gonzalez, Christina Grabarits, Steven M. Greenberg, Barbara Gregson, Daryl R. Gress, Eugene Gu, Gaurav Gupta, Christiana E. Hall, Daniel F. Hanley, Yi Hao, Sagi Harnof, Mark R. Harrigan, F. Muñoz, Robert Hoesch, Brian L. Hoh, Jennifer Houser, Rong Hu, Judy Huang, Yi Huang, Mohammed Akbar Hussain, Salvatore Insinga, Ashutosh P. Jadhav, Jennifer Jaffe, Babak S. Jahromi, Jack Jallo, Michael L. James, Robert F. James, Scott Janis, Brian T. Jankowitz, Esther Jeon, Draga Jichici, Karin Jonczak, Ben Jonker, Nicki Karlen, Carlos S. Kase, Naureen Keric, Thomas Kerz, Ryan S. Kitagawa, Jared Knopman, Carolyn Koenig, Satish Krishnamurthy, Avinash B. Kumar, Inam Kureshi, John D. Laidlaw, Arun Lakhanpal, Karen Lane, Julius Gene Latorre, David LeDoux, Kennedy R. Lees, Dana Leifer, James Leiphart, Sarah Lenington, Yunke Li, George Α. Lopez, Darren Lovick, C. B. Lumenta, Jinbiao Luo, Matthew B. Maas, Joel MacDonald, Larami MacKenzie, Vikram Madan, Ryan Majkowski, Ottó Major, Rishi Malhorta, Marc Malkoff, Halinder S. Mangat, Ahmed Maswadeh, Charles Matouk, Steven Mayo, Kate McArthur, Nichol McBee, Scott McCaul, Joshua E. Medow, A. D. Mendelow, G Mezey, Janet Mighty, David Miller, Patrick Mitchell, Krishna Mohan, Patricia Lynn Money, W. Andrew Mould, Keith W. Muir, Lorenzo Muñoz, Peter Nakaji, Alex Nee, Saman Nekoovaght-Tak, Paul Nyquist, Roddy O’Kane, Mohamed Okasha, Cian O′Kelly, Noeleen Ostapkovich, Aditya Pandey, Adrian Parry‐Jones, Hiren C. Patel, Krissia M. Rivera Perla, Ania Pollack, Sean P. Polster, Nader Pouratian, Terry Quinn, Ventatakrishna Rajajee, Kesava Reddy, Mohammed Rehman, Ronald Reimer, Fred Rincón, Michael Rosenblum, Igor Rybinnik, B. Sánchez, Lauren Sansing, Rosario Sarabia, Michael Schneck, Ludwig Schuerer, David B. Schul, Jeffrey S. Schweitzer, David B. Seder, Donald Seyfried, Kevin N. Sheth, Alejandro M Spiotta, Agnieszka Stadnik, Michael T. Stechison, Elizabeth A. Sugar, Katalin Szabó, Gonzalo Tamayo, Krisztián Tánczos, Philipp Taussky, Jeanne Teitelbaum, John Terry, Fernando D. Testai, Kathrine Thomas, Carol B. Thompson, Gregory Thompson, Richard E. Thompson, James C. Torner, Huy Tran, Kristi Tucker, Natalie Ullman, Lior Ungar, Andreas Unterberg, Panos Varelas, Nataly Montano Vargas, Hartmut Vatter, Chitra Venkatasubramanian, Krista Vermillion, Paul Vespa, Dennis G. Vollmer, Weimin Wang, Yan Wang, Ying Wang, Jiajun Wen, Louis Tony Whitworth, Byron Willis, Alastair Wilson, Stacey Q Wolfe, Myriha Wrencher, Shawn E. Wright, Yong-ge Xu, Lisa R Yanase, Gayane Yenokyan, Xuxia Yi, Zhiyuan Yu, Wendy Ziai, Ali Zomorodi, Mario Zuccarello - Science Immunology 2021 cited by 77

, which, in turn, augmented VEGF production. Our findings define the time course of myeloid activation in the human brain after ICH, revealing a conserved progression of immune responses from proinflammatory to proresolution states in humans after brain injury and identifying transcriptional programs associated with neurological recovery.