Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity

Authors: Shin‐ichi Fukuda, Siddharth Narendran, Akhil Varshney, Yosuke Nagasaka, Shao-Bin Wang, Kameshwari Ambati, Ivana Apicella, Felipe Pereira, Benjamin J. Fowler, Tetsuhiro Yasuma, Shuichiro Hirahara, Reo Yasuma, Peirong Huang, Praveen Yerramothu, Ryan D. Makin, Mo Wang, Kirstie Baker, Kenneth M. Marion, Xiwen Huang, Elmira Baghdasaryan, Meenakshi Ambati, Vidya L. Ambati, Daipayan Banerjee, Vera L. Bonilha, Genrich V. Tolstonog, Ulrike Held, Yuichiro Ogura, Hiroko Terasaki, Tetsuro Oshika, Deepak Bhattarai, Kyung Bo Kim, Sanford H. Feldman, J. Ignacio Aguirre, David R. Hinton, Nagaraj Kerur, Srinivas R. Sadda, Gerald G. Schumann, Bradley D. Gelfand, Jayakrishna Ambati - Science Advances 2021 cited by 51

cDNA toxicity, identifying inflammasome activation as the terminal effector of RPE degeneration.