Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Authors: Elizabeth K. Speliotes, Cristen J. Willer, S. I. Berndt, Keri L. Monda, Guðmar Þorleifsson, Anne Jackson, Hana Lango Allen, Cecilia M. Lindgren, Jian Luan, Reedik Mägi, Joshua C. Randall, Sailaja Vedantam, Thomas W. Winkler, Lu Qi, Tsegaselassie Workalemahu, Iris M. Heid, Valgerður Steinthórsdóttir, Heather M. Stringham, Michael N. Weedon, Eleanor Wheeler, Abigail Wood, Teresa Ferreira, Robert J. Weyant, Ayellet V. Segrè, Karol Estrada, Liming Liang, James Nemesh, J. H. Park, Stefan Gustafsson, Tuomas O. Kilpeläinen, Jian Yang, Nabila Bouatia‐Naji, Tõnu Esko, M.F. Feitosa, Zoltán Kutalik, Massimo Mangino, Soumya Raychaudhuri, André Scherag, Albert V. Smith, Ryan Welch, Jing Hua Zhao, Katja K.H. Aben, Devin Absher, Najaf Amin, Anna Dixon, Eva Fisher, Nicole L. Glazer, Michael E. Goddard, Nancy L. Heard‐Costa, Volker Hoesel, Jouke‐Jan Hottenga, Åsa Johansson, Toby Johnson, Shamika Ketkar, Claudia Lamina, S. Li, Miriam F. Moffatt, Richard H. Myers, N Narisu, John R. B. Perry, Marjolein J. Peters, Michael Preuß, Samuli Ripatti, Fernando Rivadeneira, Camilla H. Sandholt, Laura J. Scott, Nicholas J. Timpson, J. P. Tyrer, S. van Wingerden, Richard M. Watanabe, Charles C. White, Fredrik Wiklund, Cristina Barlassina, Daniel I. Chasman, Matthew N. Cooper, Jan-Hakan Jansson, Robert Lawrence, Niina Pellikka, Inga Prokopenko, Jianxin Shi, Elisabeth Thiering, Helen Alavere, Maria Teresa Sciarrone Alibrandi, Peter Almgren, Alice M. Arnold, Thor Aspelund, Larry D. Atwood, Beverley Balkau, Anthony J. Balmforth, Amanda J. Bennett, Yoav Ben‐Shlomo, Richard N. Bergman, Sven Bergmann, Heike Biebermann, Alexandra I. F. Blakemore, Tanja Boes, Lori L. Bonnycastle, Stefan R. Bornstein, M. J. Brown, Thomas A. Buchanan, Fabio Busonero, Harry Campbell, Francesco P. Cappuccio, Christine Cavalcanti-Proença, Y. D. Chen, C. M. Chen, Peter S. Chines, Robert Clarke, Lachlan Coin, John Connell, Ian N.M. Day, Martin den Heijer, Jubao Duan, Shah Ebrahim, Paul Elliott, Roberto Elosúa, G. Eiríksdóttir, Michael R. Erdos, Johan G. Eriksson, Maurizio Facheris, Stephan B. Felix, Pamela Fischer‐Posovszky, Aaron R. Folsom, Nele Friedrich, Nelson B. Freimer, Minjie Fu, Stefan Gaget, PV Gejman, Eco J. C. de Geus, Christian Gieger, Anette P. Gjesing, Anuj Goel, Philippe Goyette, Harald Grallert, Juergen Graessler, Danielle M. Greenawalt, Christopher J. Groves, Vilmundur Guðnason, Candace Guiducci, Anna‐Liisa Hartikainen, Neelam Hassanali, Alistair S. Hall, Aki S. Havulinna, Caroline Hayward, Andrew C. Heath, Christian Hengstenberg, Andrew A. Hicks, Anke Hinney, Albert Hofman, Georg Homuth, Jennie Hui, Wilmar Igl, Carlos Iribarren, Bo Isomaa, Kevin B. Jacobs, Ivonne Jarick, Elizabeth S. Jewell, Ulrich John, Torben Jørgensen, Pekka Jousilahti, Antti Jula, Marika Kaakinen, Eero Kajantie, Lee M. Kaplan, Sekar Kathiresan, JA Kettunen, Leena Kinnunen, Joshua W. Knowles, Ivana Kolčić, Inke R. König, Seppo Koskinen, Péter Kovács, Johanna Kuusisto, Peter Kraft, Kirsti Kvaløy, Jaana Laitinen, Olivier Lantieri, Chiara Lanzani, Lenore J. Launer, Cécile Lecœur, Terho Lehtimäki, Guillaume Lettre, J. Liu, Marja‐Liisa Lokki, Mattias Lorentzon, Robert Luben, Barbara Ludwig, Paolo Manunta, Diana Marek, Michel Marre, Nicholas G. Martin, Wendy L. McArdle, Anne McCarthy, Barbara McKnight, Thomas Meitinger, Olle Melander, David Meyre, Kristian Midthjell, Grant W. Montgomery, Mario A. Morken, A. P. Morris, Rosanda Mulić, Julius S. Ngwa, Mari Nelis, Matt J. Neville, Dale R. Nyholt, Chris O’Donnell, Stephen O’Rahilly, KL Ong, B. A. Oostra, Guillaume Paré, Alex Parker, Markus Perola, Irene Pichler, Kirsi H. Pietiläinen, Carl G. P. Platou, Ozren Polašek, Anneli Pouta, Suzanne Rafelt, Olli Raitakari, Nigel W. Rayner, Martin Ridderstråle, Winfried Rief, Aimo Ruokonen, Neil R. Robertson, Peter Rzehak, Veikko Salomaa, Alan R. Sanders, Manjinder S. Sandhu, Serena Sanna, J. Saramies, Markku J. Savolainen, Susann Scherag, Sabine Schipf, Stefan Schreiber, Heribert Schunkert, Kaisa Silander, Juha Sinisalo, David S. Siscovick, Jan Smit, Nicole Soranzo, Ulla Sovio, Jonathan Stephens, Ida Surakka, Amy J. Swift, M. L. Tammesoo, Jean‐Claude Tardif, Maris Teder‐Laving, Tanya M. Teslovich, John R. Thompson, Brian Thomson, Anke Toenjes, Jaakko Tuomilehto, Joyce B. J. van Meurs, G J van Ommen, Vincent Vatin, Jorma Viikari, Sophie Visvikis‐Siest, Véronique Vitart, Carla Ivane Ganz Vogel, Benjamin F. Voight, Lindsay L. Waite, Henri Wallaschofski, G. Bragi Walters, Elisabeth Widén, Susanna Wiegand, SH Wild, Gonneke Willemsen, Daniel R. Witte, Jacqueline C.M. Witteman, Jianfeng Xu, Qunyuan Zhang, Lina Zgaga, Andreas Ziegler, Paavo Zitting, John Beilby, I. Sadaf Farooqi, Johannes Hebebrand, Heikki Huikuri, Anthony James, Mika Kähönen, D. F. Levinson, Fabìo Macciardi, Markku S. Nieminen, Claes Ohlsson, Lyle J. Palmer, Paul M. Ridker, Michael Stümvoll, J. Beckmann, Heiner Boeing, Eric Boerwinkle, Dorret I. Boomsma, Mark J. Caulfield, Stephen J. Chanock, Francis S. Collins, L. Adrienne Cupples, George Davey Smith, Jeanette Erdmann, Philippe Froguel, Henrik Grönberg, Ulf Gyllensten, Per Hall, Torben Hansen, Tamara B. Harris, Andrew T. Hattersley, Richard B. Hayes, Joachim Heinrich, Frank B. Hu, Kristian Hveem, Thomas Illig, Marjo‐Riitta Järvelin, Jaakko Kaprio, Fredrik Karpe, Kay‐Tee Khaw, L. A. Kiemeney, Heiko Krude, Markku Laakso, Debbie A. Lawlor, Andres Metspalu, Patricia B. Munroe, Willem H. Ouwehand, Oluf Pedersen, Brenda W.J.H. Penninx, Annette Peters, Peter P. Pramstaller, Thomas Quertermous, Thomas Reinehr, Aila Rissanen, Igor Rudan, N. J. Samani, Peter Schwarz, Alan R. Shuldiner, T. D. Spector, J. Tuomilehto, Manuela Uda, André G. Uitterlinden, T. T. Valle, Martin Wabitsch, Gérard Waeber, Nicholas J. Wareham, Hugh Watkins, J. Frank Wilson, Alan F. Wright, M. Carola Zillikens, N. Chatterjee, Steven A. McCarroll, Shaun Purcell, E. E. Schadt, Peter M. Visscher, Themistocles L. Assimes, Ingrid B. Borecki, Panos Deloukas, Caroline S. Fox, Leif Groop, Talin Haritunians, David J. Hunter, R.C. Kaplan, Karen L. Mohlke, Jeffrey R. O’Connell, Laura‐Maria Peltonen, David Schlessinger, D. P. Strachan, Cornelia M. van Duijn, H-Erich Wichmann, Timothy M. Frayling, U. Thorsteinsdottir, Gonçalo R. Abecasis, Inês Barroso, Michael Boehnke, Kāri Stefánsson, K. E. North, Mark I. McCarthy, J. N. Hirschhorn, Erik Ingelsson, Ruth J. F. Loos - University of North Carolina at Chapel Hill 2010 cited by 767

Obesity is globaLy prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined aSociations betwEn body maS index and ĝ̂1/42.8 miLion SNPs in up to 123,865 individuals with targeted foLow up of 42 SNPs in up to 125,931 aDitional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci aSociated with body maS index (P < 5-10 -8 ), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly aSociated loci may provide new insights into human body weight regulation. © 2010 Nature America, Inc. All rights reserved.