Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections

Authors: Franziska Schmidt, Andreas Thywißen, Marie Goldmann, Cristina Cunha, Zoltán Cseresnyés, Hella Schmidt, Muhammad Rafiq, Silvia Galiani, Markus H. Gräler, Georgios Chamilos, João F. Lacerda, António Campos, Christian Eggeling, Marc Thilo Figge, Thorsten Heinekamp, Scott G. Filler, Agostinho Carvalho, Axel A. Brakhage - Cell Reports 2020 cited by 66

-dependent calmodulin activity led to reduced lipid-raft formation. We identify a single-nucleotide polymorphism in the human FLOT1 gene resulting in heightened susceptibility for invasive aspergillosis in hematopoietic stem cell transplant recipients. Collectively, flotillin-dependent microdomains on the phagolysosomal membrane play an essential role in protective antifungal immunity.