Impacts of gold nanoparticle charge and ligand type on surface binding and toxicity to Gram-negative and Gram-positive bacteria

Authors: Z. Vivian Feng, Ian L. Gunsolus, Tian Qiu, Katie R. Hurley, Lyle H. Nyberg, Hilena Frew, Kyle Johnson, Ariane Vartanian, Lisa Jacob, Samuel E. Lohse, Marco D. Torelli, Robert J. Hamers, Catherine J. Murphy, Christy L. Haynes - Chemical Science 2015 cited by 253

using flow cytometry. The NP concentration-dependent binding profiles were drastically different for the two bacteria strains, suggesting the critical role of bacterial cell surface chemistry in determining nanoparticle association, and thereby, biological impact.