Nipah Virus V Protein Binding Alters MDA5 Helicase Folding Dynamics

Authors: Nicole D. Wagner, Hejun Liu, Henry W. Rohrs, Gaya K. Amarasinghe, Michael L. Gross, Daisy W. Leung - ACS Infectious Diseases 2021 cited by 15

binding, these β-sheet and adjacent residues show significant protection. Collectively, our findings suggest that NiV V binding disrupts the helicase fold and dynamics of MDA5 to antagonize host antiviral immunity.