Novel Plasmid-Mediated tet (X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate

Authors: Liyuan Wang, Dejun Liu, Yuan Lv, Lanqing Cui, Yun Li, Tianmeng Li, Huangwei Song, Yuxin Hao, Jianzhong Shen, Yang Wang, Timothy R. Walsh - Antimicrobial Agents and Chemotherapy 2019 cited by 172

A novel, plasmid-mediated, high-level tigecycline resistance tet (X) gene variant, tet (X5), was detected in a clinical Acinetobacter baumannii isolate from China in 2017. Tet(X5) shows 84.5% and 90.5% amino acid identity to Tet(X3) and Tet(X4), respectively, with similar binding sites and a comparable affinity for tetracyclines. The tet (X5)-containing plasmid could only be transferred to A. baumannii via electrotransformation.