Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence

Authors: Kevin Pérez, Serban Ciotlos, Julia McGirr, Chandani Limbad, Ryosuke Doi, Joshua P. Nederveen, Mats I. Nilsson, Daniel A. Winer, William J. Evans, Mark A. Tarnopolsky, Judith Campisi, Simon Melov - Aging 2022 cited by 101

-driven senescence in this subpopulation. Overall, our findings identify unique cellular subpopulations in aged and sarcopenic skeletal muscle, which will facilitate the development of new therapeutic strategies to combat age-related frailty.