An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression

Asís Palazón; Petros A. Tyrakis; David Macías; Pedro Veliça; Helene Rundqvist; Susan F. Fitzpatrick; Nikola Vojnović; Anthony T. Phan; Niklas Loman; Ingrid Hedenfalk; Thomas Hatschek; John Lövrot; Theodoros Foukakis; Ananda W. Goldrath; Jonas Bergh; Randall S. Johnson

doi:10.1016/j.ccell.2017.10.003

An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression

Authors: Asís Palazón, Petros A. Tyrakis, David Macías, Pedro Veliça, Helene Rundqvist, Susan F. Fitzpatrick, Nikola Vojnović, Anthony T. Phan, Niklas Loman, Ingrid Hedenfalk, Thomas Hatschek, John Lövrot, Theodoros Foukakis, Ananda W. Goldrath, Jonas Bergh, Randall S. Johnson - Cancer Cell 2017 cited by 530

T cell infiltration, and a link between T cell infiltration and vascularization. These data demonstrate that the HIF-1α/VEGF-A axis is an essential aspect of tumor immunity.