Single-cell transcriptome profiling and chromatin accessibility reveal an exhausted regulatory CD4+ T cell subset in systemic lupus erythematosus

Authors: Chuang Guo, Qian Liu, Dandan Zong, Wen Zhang, Zu-Qi Zuo, Qiaoni Yu, Qing Sha, Lin Zhu, Xuyuan Gao, Jingwen Fang, Jin‐Hui Tao, Quan Wu, Xiaomei Li, Kun Qu - Cell Reports 2022 cited by 68

Treg subgroup features type I interferon-induced functional exhaustion in SLE patients. These transcriptome-level findings for SLE Tregs are mirrored in trends from the ATAC-seq data. Our study establishes a rich empirical foundation for understanding SLE and uncovers previously unknown contributions of Treg with exhaustion-like properties to SLE pathogenesis.