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Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits

Authors: Randall J. Platt, Yang Zhou, Ian M. Slaymaker, Ashwin S. Shetty, Niels R. Weisbach, Jin-Ah Kim, Jitendra Sharma, Mitul Desai, Sabina Sood, H. Kempton, Gerald R. Crabtree, Guoping Feng, Feng Zhang - Cell Reports 2017 cited by 246

animals, suggesting a role for CHD8 in adult striatal circuits. These results support a mechanism linking chromatin modification to striatal dysfunction and the molecular pathology of ASD.

Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits | Litlas