Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K/Akt-p27 Kip1 signaling axis

Authors: Sungmin Nam, Vivek Kumar Gupta, Hong-Pyo Lee, Joanna Y. Lee, Katrina M. Wisdom, Sushama Varma, Eliott Flaum, Ciara Davis, Robert B. West, Ovijit Chaudhuri - Science Advances 2019 cited by 201

signaling axis, but growth is inhibited in the confining slow-relaxing hydrogels. Thus, in confining microenvironments, cells sense when growth is sufficient for division to proceed through a growth-responsive signaling axis mediated by SACs.