Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities

Authors: Min Seo Kim, Injeong Shim, Akl C. Fahed, Ron Do, Woong-Yang Park, Pradeep Natarajan, Amit V. Khera, Hong‐Hee Won - Cell Metabolism 2024 cited by 105

< 0.001). Absolute differences in obesity risk between those who adhere to healthy lifestyles and those who do not had gradually expanded with an increase in polygenic score. Despite a high genetic risk for obesity, individuals can prevent obesity-related morbidities by adhering to a healthy lifestyle and maintaining a normal body weight. Healthy lifestyles should be promoted irrespective of genetic background.