Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant

selectively disrupts the induction of IFN-γ by IL-23 and is a common monogenic etiology of tuberculosis.

Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant | Litlas