Hematopoietic origin of Langerhans cell histiocytosis and Erdheim-Chester disease in adults

Authors: Paul Milne, Venetia Bigley, Chris M. Bacon, A. Néel, Naomi McGovern, Simon Bomken, Muzlifah Haniffa, Eli L. Diamond, Benjamin H. Durham, Johannes Visser, David Hunt, Harsha Gunawardena, Mac Macheta, Kenneth L. McClain, Carl E. Allen, Omar Abdel‐Wahab, Matthew Collin - Blood 2017 cited by 191

DCs, made foamy macrophages easily in vitro with macrophage colony-stimulating factor and human serum. These studies are consistent with a hematopoietic origin and >1 immediate cellular precursor in both LCH and ECD.