Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial

Authors: Hiddo J.L. Heerspink, Jai Radhakrishnan, Charles E. Alpers, Jonathan Barratt, Stewart Bieler, Ulysses Diva, Jula K. Inrig, Radko Komers, Alex Mercer, Irene L. Noronha, Michelle N. Rheault, William E. Rote, Brad H. Rovin, Howard Trachtman, Hernán Trimarchi, Muh Geot Wong, Vlado Perkovic, Eric Alarmartine, Jonathan Barratt, Dong‐Wan Chae, Lucia Del Vecchio, Jürgen Floege, Shang‐Jyh Hwang, Bojan Jelaković, Bart Maes, Robert Małecki, Marius Miglinas, Fernando Nolasco, M Praga, Kannaiyan S Rabindranath, Mai Rosenberg, Brad H. Rovin, Sydney Tang, Vladmir Tesar, Muh Geot Wong, Bhadran Bose, Muralikrishna Gangadharan, Stephen P. McDonald, Chen Au Peh, Sadia Jahan, Chii Yeap, Philip A. Clayton, Georgina Irish, Nikhil Thyagarajan, Peter Hollett, Rathika Krishnasamy, Robert J. Carroll, Shilpanjali Jesudason, Susan Crail, Toby Coates, Jane Waugh, Euan Noble, Kumaradevan Mahadevan, Victoria Campbell, Tania Salehi, Wai H. Lim, Neil Boudville, Aron Chakera, Doris Chan, Anoushka Krishnan, Yusuf Eqbal, Alastair Gillies, Eswari Vilayur, Thida Maung Myint, Nicholas A. Gray, Jane Waugh, Euan Noble, Melissa S Cheetham, Yusuf Eqbal, Peter Hollett, Rathika Krishnasamy, Kumaradevan Mahadevan, Victoria Campbell, Carol A. Pollock, Bruce A. Cooper, Amanda Mather, Sarah Roxburgh, Yvonne Shen, Stefanie Stangenberg, Amanda Siriwardana, Emma O’Lone, Susan Wan, Brendon L. Neuen, Jeffrey T. Ha, Dana Kim, Lauren Heath, Arunima Jain, Elaine Phua, Li Yan, M. W. Gallagher, Meg Jardine, Angus Ritchie, Mona Razavian, Celine Foote, Roger Wyndham, Shaundeep Sen, Zoltán Endre, Jonathan Erlich, Mangalee Fernando, Kenneth Yong, Grant Luxton, Sradha Kotwal, Simon D. Roger, Vidu Wijeratne, David Packham, Ian Fraser, Bert Vandewiele, Margo Laute, Wim Lemahieu, Sofie Jamar, Sara Ombelet, Gert Meeus, Marc Decupere, Olivier P. Schockaert, Peter Doubel, Liesbeth Viaene, Luc Radermacher, Catherine Masset, Martial Moonen, Éric Firre, Martina Milicevic, Xavier Warling, An Vanacker, Thomas Malfait, Ivan Durlen, Ivica Horvatić, Ana Šavuk, Lana Gellineo, Sandra Karanović, Živka Dika, Djuro Plavljanic, Ivana Mikačić, Dubravka Trajbar Kentric, Dunja Barisic, Marija Stanković, Karolina Majstorović Barać, Ivan Kruljac, Draško Pavlović, Martin Drinković, Ingrid Prkačin, Jerko Barbić, Zvonimir Sitaš, Dunja Vujčić, Ivan Rychlík, Anna Benesova, Klara Drinovska, Karolína Krátká, Dita Maixnerová, Madis Ilmoja, Kristin Unt, Kadri Lilienthal, Asta Auerbach, Liisi Leis, Julia Piel, Annika Adoberg, Külli Kõlvald, Kristi Veermae, Kadri Telling, Elviira Seppet, Jana Uhlinova, Philippe Zaoui, Pierre‐Louis Carron, Ingrid Masson, M. Dinic, Damien Thibaudin, C Broyet, Nicolas Maillard, Hesham Mohey, Christophe Mariat, Guillaume Claisse, É. Alamartine, Bertrand Dussol, Stéphane Burtey, Noemie Chiche-Jourde, Jean‐Emmanuel Serre, Guillaume Jeantet, Leïla Chénine, Anne Blanchard, Stéphane Roueff, Éric Thervet, David Fouassier, Alexandre Buffet, Marine Livrozet, Roxane Gaïsset, Alexandre Karras, Anne-Elisabeth Heng, Cyril Garrouste, Carole Philipponnet, C. Nicolò, Alba Atenza, Camille Lanaret, Clarisse Grèze, Valentin Mayet, Clément Dumond, Yahsou Delmas, Christian Combe, Claire Rigothier, Laure Burguet, Aurore Labat, Simon Mucha, V. de Précigout, Thomas Weinreich, Helmut Reichel, Diliana Draganova, Lothar Wolf, Bernd Hohenstein, Sven Heinrichs, Simone Kulka, Sebahat Şat, Lea Weiland, Thilo Krueger, Günter Wolf, Christiane Kettner, Mandy Schlosser, Johann Konstantin Herfurth, Annegret Koch, Martin Busch, Stephan Christian Werth, Martin Nitschke, Figen Cakiroglu, Franziska Sarnow, Lisa Schulz, Stefan M. Weiner, Nikolaus Wirtz, Eric Koester, Marcus J. Moeller, Eleni Stamellou, Silja K. Sanden, Hans Schmidt-Guertler, Wanja Bernhardt, Margret Patecki, Georg Schlieper, Kevin Schulte, Annette Girardet, Ulrich Kunzendorf, Lorraine Pui Yuen Kwan, Maggie Ming Yee Mok, Gary C.W. Chan, Mingyao Ma, Davina Ngoi Wah Lie, Anthony Ting Pong Chan, Cheuk‐Chun Szeto, Jack Kit‐Chung Ng, Siu Fai Cheung, Tak Tai Andrew Yue, Samuel Fung, Hon Tang, Ka Fai Yim, Wai Ping Law, Yick Hei Wong, Chi Kwan Darwin Lam, Sze Ho Sunny Wong, Carmelita Marcantoni, Roberta Aliotta, Francesca Deodato, Gemma Patella, Nicolino Comi, Caterina Vita, Nazareno Carullo, Davide Bolignano, Michela Musolino, Matias Trillini, Norberto Perico, Giuseppe Remuzzi, Erica Daina, Luigi Biancone, Loredana Colla, Manuel Burdese, C Cogno, Elena Boaglio, Isabella Abbasciano, Carlotta Federica Zizzi, Paolo Randone, Pietro Napodano, Anna Ricchiuto, Matthias Cassia, Simone Accarino, Mario Cozzolino, Rocco Baccaro, Stefano Costanzi, Federica Di Maio, Maria Arena, Federica Urciuolo, Sara Viganò, Andrea Cavalli, Monica Limardo, M Bordoli, Serena Ponti, Selena Longhi, Andrea Solazzo, Francesco Giaroni, Gabriele Donati, Massimo Torreggiani, Davide Catucci, Marco Colucci, Vittoria Esposito, Ciro Esposito, Loreto Gesualdo, Flavia Capaccio, Emma Diletta Stea, Carmen Sivo, Francesca Annese, Federica Papadia, Piergiorgio Messa, Mirco Belingheri, Patrizia Passerini, Silvia Malvica, Alvita Vickienė, Urtė Žakauskienė, Eglė Ašakienė, Inga Arūnė Bumblytė, Asta Stankuvienė, Lina Santockiene, Ashik Hayat, Allister Williams, Peter Sizeland, Eddie Tan, Gerald P Waters, Lai Wan Chan, Andrew Henderson, Angus Turnbull, Andrew McNally, Annie Reynolds, Helen Pilmore, Ian Dittmer, Paul W. Manley, Elizabeth Stallworthy, Tze Liang Goh, David Semple, Michael Collins, Elizabeth Curry, Jafar Ahmed, Thu Nguyen, Agata Winiarska, Justyna Zbrzeźniak, Tomasz Stompór, Magdalena Krajewska, Hanna Augustyniak‐Bartosik, Dorota Zielińska, Anna Jander, Małgorzata Stańczyk, Marcin Tkaczyk, Przemysław Miarka, Dariusz Aksamit, Piotr Jaśkowskí, Władysław Sułowicz, Dominik Cieniawski, Julita Gontarek-Kacprzak, Elzbieta Felicjanczuk, Norbert Kwella, Bogna Kwella, Ewa Satora, João Carlos Fernandes, Ana Marta Gomes, Marina Reis, Daniela Lopes, Catarina Almeida, Helena Sá, Ana Figueiredo, Clara Pardinhas, Edgar Almeida, Mário Raimundo, Ana Cortesão Costa, Luis Pedro Falcao Goncalves, Sara Fernandes, Sónia Silva, Catarina Teixeira, Adriana Fernandes, Fernando Nolasco, Patrícia Marques‐Alves, Mário Góis, Nuno Moreira Fonseca, Ana Messias, Maria Do Mar Menezes, Filipa Cardoso, Helena Sousa, Joana Marques, Rui Barata, José António Lopes, Sofía Jorge, Joana Gameiro, José Nuno Fonseca, Sara Gonçalves, Ana Farinha, Patricia Valerio Santos, Ana Natário, José C. Barreto, Catarina Abrantes, Elsa Sofia Quadrado Soares, Joana Felgueiras, Liliana Cunha, Lúcia Parreira, Teresa Furtado, Álvaro Vaz, Kook‐Hwan Oh, Hajeong Lee, Se Joong Kim, Jong Cheol Jeong, Yeong Hoon Kim, Yunmi Kim, Hyeong Cheon Park, Hoon Young Choi, Hyung Wook Kim, Moon‐Hyoung Lee, Songuk Yoon, Kyu‐Beck Lee, YoungYoul Hyun, Tae‐Hyun Yoo, Seung Hyeok Han, Jung Tak Park, Sunggyun Kim, Young Song, Jwa-Kyung Kim, Hyungseok Lee, Narae Joo, Jung Eun Lee, Hye Ryoun Jang, Junseok Jeon, Wookyung Chung, Hyun‐Hee Lee, Jae Hyun Chang, Ka Yeong Chun, Ji Yong Jung, Han Ro, Aejin Kim, Sang‐Kyung Jo, Jihyun Yang, Myung-Gyu Kim, Se Won Oh, Caridad Martinez Villanueva, Ana Vilar Gimeno, Gustavo Andres Useche Bonilla, E. Alba Tamarit, Antonio Galán Serrano, Eduardo Verde Moreno, José Luño Fernández, María Ángeles Goicoechea Diezhandino, Úrsula Verdalles Guzmán, Ana Pérez de José, Alberto Ortiz Arduan, María Vanessa Pérez-Gómez, Catalina Martín Cleary, Raúl Fernández Prado, Elena Gomá-Garcés, José Ballarín, Montserrat M. Díaz Encarnación, Iara Da Silva Santos, Helena Marco Rusiñol, Mónica Furlano, Carlos Arias, Clara Barrios, Eva Rodriguez Garcia, Adriana Sierra Ochoa, Belén Vizcaíno Castillo, Jonay Pantoja Perez, Mercedes González Moya, Mari Sargsyan, Emma Calatayud Aristoy, Ana Ávila Bernabéu, Leticia Perez Lluna, Tamara Malek Marin, María Antonia Munar Vila, Ivon Maritza Bobadilla Rico, Natalia Allende Burgos, Eduardo Gutiérrez Martínez, Elena Gutiérrez Solís, Ángel Sevillano, Evangelina Merida Herrero, Josep Miquel Blasco Pelicano, Lida María Rodas Marín, Luís F. Quintana, Maria Antonieta Azancot Rivero, Natàlia Ramos, Clara García Carro, Irene Agraz Pamplona, Mercedes Salgueira Lazo, Francisco de la Prada Álvarez, Fabiola Alonso García, Wenceslao Adrian Aguilera Morales, Salia Virxinia Pol Heres, Ángel Blasco Forcén, Eduardo Parra Moncasi, Cristina Medrano Villarroya, Alejandro Soria Villen, Olga Gracia García, Mercedes Velo Plaza, María Dolores Sánchez de la Nieta, Marta Calvo Arevalo, Antolina Moreno, Secundino Cigarrán, Manuel Pereira de Vicente, María Antonia Munar Vila, Ivon Maritza Bobadilla Rico, Natalia Allende Burgos, Bang‐Gee Hsu, Chih‐Hsien Wang, Cheng‐Hsu Chen, Tung‐Min Yu, Ming‐Ju Wu, Shang‐Feng Tsai, Chia‐Tien Hsu, Hsien‐Fu Chiu, Kang‐Ju Chou, Hua‐Chang Fang, Po‐Tsang Lee, Hsin‐Yu Chen, Chien‐Liang Chen, Chien‐Wei Huang, Shih‐Hsiang Ou, Tzung‐Yo Ho, Chih‐Yang Hsu, Ming-Shan Chang, Yen‐Ling Chiu, Yu‐Sen Peng, Kai-Hsiang Shu, Szu‐Yu Pan, Shih‐Ping Hsu, Ju‐Yeh Yang, Mei‐Fen Pai, Po‐Yu Tseng, Hon‐Yen Wu, Wan‐Chuan Tsai, Kuei‐Ting Tung, Hung‐Yuan Chen, Hung‐Chun Chen, Mei‐Chuan Kuo, Daw‐Yang Hwang, Yi‐Wen Chiu, Chi‐Chih Hung, Hung‐Tien Kuo, Jer‐Chia Tsai, Kieran McCafferty, Suzanne Forbes, Indranil Dasgupta, Mark Thomas, Amar Mahdi, Bamidele Ajayi, Paramit Chowdhury, Theodoros Kasimatis, D.-A. Moutzouris, Caroline Dudreuilh, Rishi Pruthi, Nick Mansfield, Gabriel Doctor, Sapna Shah, Sui Phi Kon, Priscilla Smith, Patrick Hamilton, Durga Kanigicherla, Omar Ragy, Bassam Alchi, Oliver Floßmann, Farid Ghalli, Sarah Lawman, Smeeta Sinha, Constantina Chrysochou, Chukwuma Chukwu, Aine Maire De Bhailis, Saif Al‐Chalabi, Amy Hudson, Arun Gopu, Olivia Wickens, Joshua Storrar, Mona Wahba, Nathan Lorde, Mohammad Rabiul Islam Rony, Siân Griffin, Farah Latif, Mohammad Ali, Louise DaSilva, Jonathan Ayling-Smith, Eamon Mahdi, Lisa Willcocks, Rachel Jones, Chee Kay Cheung, Haresh Selvaskandan, Dan Pugh, Matthew Sayer, Neeraj Dhaun, Fiona A. Chapman, Patrick B. Mark, Colin Geddes, Emily P. McQuarrie, Rajan Patel, Laurence Solomon, Arvind Ponnusamy, Adam Morris, Pedro Okoh, Lauren Floyd, Ajay Dhaygude, Janson Leung, Christopher Goldsmith, Bhavna Pandya, Didem Tez, Ashraf Mikhail, Karen Brown, Thomas Bucknall, Mark Lambie, Roderick Comunale, Donald Brandon, Stacy Martinez, Amanda K. Hall, Amy Henderson, Aaron Fearday, Nicole Douthit, Brian Snow, Arnold Silva, Cathylee Sly, Christopher Keller, Robert M. Davidson, Jerry Meng, Robert Haws, Siddhartha Kattamanchi, Javad Najjar Mojarrab, Unnikrishnan Pillai, Richard Lafayette, Michelle M. O’Shaughnessy, Fahameedah Kamal, Kshama Mehta, Bruce Baker, Mario Ruiz, Praveena Jyothinagaram, Usha Peri, William G. Paxton, James Tumlin, Kerri McGreal, Ellen T. McCarthy, Cassandra Kimber, Archana Gautam, Kassem Khalil, Viet Nguyen, Viet Nguyen, Raffi Minasian, Dariush Arfaania, Sam Daneshvari, Michel Zakari, Artashes Patrikyan, Rouzbeh Afsari, Christine Ayvazyan, Faisal Fakih, Mark Lagatta, Faisal Fakih, Alfred Rodriguez, Jorge Enrique Monroy Avella, Ramachandra Patak, Jigar Kadakia, Jai Radhakrishnan, Gerald B. Appel, Wooin Ahn, Bradley Nelson, Allyson Medina, Syeda B. Ahmad, Yonatan Peleg, Nisha Clement, Ian Chiu, Elizabeth Hendren, Andrew S. Bomback, Pietro A. 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