Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders

Authors: Jian Yang, Peng Zheng, Yifan Li, Jing Wu, Xunmin Tan, Jingjing Zhou, Zuoli Sun, Xu Chen, Guofu Zhang, Hanping Zhang, Yu Huang, Tingjia Chai, Jiajia Duan, Weiwei Liang, Bangmin Yin, Jianbo Lai, Tingting Huang, Yanli Du, Peifen Zhang, Jiajun Jiang, Caixi Xi, Lingling Wu, Jing Lü, Tingting Mou, Yi Xu, Seth W. Perry, Ma‐Li Wong, Júlio Licinio, Shaohua Hu, Gang Wang, Peng Xie - Science Advances 2020 cited by 406

These multilevel omics alterations generated a characteristic MDD coexpression network. Disturbed microbial genes and fecal metabolites were consistently mapped to amino acid (γ-aminobutyrate, phenylalanine, and tryptophan) metabolism. Furthermore, we identified a combinatorial marker panel that robustly discriminated MDD from HC individuals in both the discovery and validation sets. Our findings provide a deep insight into understanding of the roles of disturbed gut ecosystem in MDD.