Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice

Authors: Panpan Xian, Yue Hei, Rui Wang, Tian Wang, Junle Yang, Jianying Li, Zhengli Di, Zhiqin Liu, Andrius Baskys, Weiping Liu, Shengxi Wu, Qianfa Long - Theranostics 2019 cited by 393

: Our results show that MSC-Exo ameliorate inflammation-induced astrocyte alterations and that the Nrf2-NF-κB signaling pathway is involved in regulating astrocyte activation in mice. These data suggest the promising potential of MSC-Exo as a nanotherapeutic agent for the treatment of neurological diseases with hippocampal astrocyte alterations.