Infliximab for Paradoxical Reactions in Pediatric Central Nervous System Tuberculosis

Authors: Yara‐Natalie Abo, Nigel Curtis, Joshua Osowicki, Gabrielle M. Haeusler, Rachael Purcell, Seilesh Kadambari, Matthias De Wachter, Koen Vanden Driessche, Sven Dekeyzer, Lee Coleman, Nigel W. Crawford, Steve Graham, Ben J. Marais, Amanda Gwee - Journal of the Pediatric Infectious Diseases Society 2021 cited by 18

Paradoxical reactions in central nervous system tuberculosis (CNS-TB) are associated with significant morbidity and mortality. We describe 4 HIV-uninfected children treated for CNS-TB with severe paradoxical reactions unresponsive to corticosteroids. All made recovery after treatment with infliximab, highlighting the safety and effectiveness of infliximab for this complication, and need for prospective trials.