Melatonin ameliorates necrotizing enterocolitis by preventing Th17/Treg imbalance through activation of the AMPK/SIRT1 pathway

Authors: Fei Ma, Hao Hu, Xiaoyan Gao, Yao Cai, Jialiang Zhou, Puping Liang, Junjian Lv, Qiuming He, Congcong Shi, Dandan Hu, Bowei Chen, Lixin Zhu, Xin Xiao, Sitao Li - Theranostics 2020 cited by 104

These results demonstrate that melatonin-induced activation of AMPK/SIRT1 signaling regulates the balance between Th17 and Treg cells and that therapeutic strategies targeting the Th17/Treg balance via the AMPK/SIRT1 pathway might be beneficial for the treatment of NEC.