Reversible binding of hemoglobin to band 3 constitutes the molecular switch that mediates O2 regulation of erythrocyte properties

Authors: Haiyan Chu, Mary M. McKenna, Nathan A. Krump, Suilan Zheng, Laurel Mendelsohn, Swee Lay Thein, Lisa Garrett, David M. Bodine, Philip S. Low - Blood 2016 cited by 85

-dependent association of hemoglobin with band 3: (1) assembly of a glycolytic enzyme complex on the erythrocyte membrane which is associated with a shift in glucose metabolism between the pentose phosphate pathway and glycolysis, (2) interaction of ankyrin with band 3 and the concomitant regulation of erythrocyte membrane stability, and (3) release of ATP from the red cell which has been linked to vasodilation.