HMGB1 regulates erastin-induced ferroptosis via RAS-JNK/p38 signaling in HL-60/NRASQ61L cells.

Authors: Fanghua Ye, Wenwen Chai, Min Xie, Minghua Yang, Yu Yan, Lizhi Cao, Liangchun Yang - National Institutes of Health 2019 cited by 182

cells had lower PTGS2 and TfR1 expression than that in control mice. Taken together, these results suggest that HMGB1 is a novel regulator of ferroptosis via the RAS-JNK/p38 pathway and a potential drug target for therapeutic interventions in leukemia.