Manganese(ii) complexes stimulate antitumor immunity via aggravating DNA damage and activating the cGAS-STING pathway

Authors: Linxiang Cai, Ying Wang, Yayu Chen, Hanhua Chen, Tao Yang, Shuren Zhang, Zijian Guo, Xiaoyong Wang - Chemical Science 2023 cited by 72

Mn complexes act as breakers of DNA to induce DSB, as inhibitors of HDAC and PARP to impede DNA repair, and as activators of the cGAS-STING pathway to trigger immune responses, thereby stimulating T cells to suppress tumor growth in a synergic mechanism.