Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset

Authors: Ina A. Stelzer, Mohammad Sajjad Ghaemi, Xiaoyuan Han, Kazuo Ando, Julien Hédou, Dorien Feyaerts, Laura S. Peterson, Kristen K. Rumer, Eileen S. Tsai, Edward A. Ganio, Dyani Gaudillière, Amy S. Tsai, Benjamin Choisy, L. Gaigne, Franck Verdonk, Danielle R. Jacobsen, Sonia Gavasso, Gavin M. Traber, Mathew Ellenberger, Natalie Stanley, Martin Becker, Anthony Culos, Ramin Fallahzadeh, Ronald J. Wong, Gary L. Darmstadt, Maurice L. Druzin, Virginia D. Winn, Ronald S. Gibbs, Xuefeng B. Ling, Karl G. Sylvester, Brendan Carvalho, M Snyder, Gary M. Shaw, David K. Stevenson, Kévin Contrepois, Martin S. Angst, Nima Aghaeepour, Brice Gaudillière - Science Translational Medicine 2021 cited by 143

= 10, independent test set]. Coordinated alterations in maternal metabolome, proteome, and immunome marked a molecular shift from pregnancy maintenance to prelabor biology 2 to 4 weeks before delivery. A surge in steroid hormone metabolites and interleukin-1 receptor type 4 that preceded labor coincided with a switch from immune activation to regulation of inflammatory responses. Our study lays the groundwork for developing blood-based methods for predicting the day of labor, anchored in mechanisms shared in preterm and term pregnancies.