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CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development

Authors: Etienne Melese, Elizabeth Franks, Rachel A. Cederberg, Bryant Harbourne, Rocky Shi, Brennan J. Wadsworth, Jenna L. Collier, Elizabeth C. Halvorsen, Fraser Johnson, Jennifer Luu, Min Hee Oh, Vivian Lam, Gerald Krystal, Shelley Hoover, Mark Raffeld, Richard J. Simpson, Arun M. Unni, Wan L. Lam, Stephen Lam, N. B. Abraham, Kevin L. Bennewith, William W. Lockwood - OncoImmunology 2021 cited by 65

expression correlates with poor prognosis, immunosuppressive regulatory T cells, and alteration to CD8 effector function in lung adenocarcinoma patients. Our data support targeting CCL5 or CCL5 receptors on immune suppressive cells to prevent formation of an immune suppressive tumor microenvironment that promotes lung cancer progression and immunotherapy insensitivity.

CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development | Litlas