LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network

Authors: Yin Zhang, Yongxin Huang, Dan-Lan Wang, Bing Yang, Haiyan Yan, Lehang Lin, Yun Li, Jie Chen, Li‐Min Xie, Yongsheng Huang, Jian‐You Liao, Kaishun Hu, Jiehua He, Phei Er Saw, Xiaoding Xu, Dong Yin - Theranostics 2020 cited by 202

Our study demonstrated that lncRNA DSCAM-AS1 was transcriptionally activated by super-enhancers driven by FOXA1 and exhibited lineage-specific expression pattern. DSCAM-AS1 can promote cancer progression by interacting with YBX1 and regulating expression of FOXA1 and ERα.