Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes

Authors: Dries Feyen, Wesley L. McKeithan, Arne A.N. Bruyneel, Sean Spiering, Larissa Hörmann, Bärbel Ulmer, Hui Zhang, Francesca Briganti, Michaela Schweizer, Bence Hegyi, Zhandi Liao, Risto-Pekka Pölönen, Kenneth S. Ginsburg, Chi Keung Lam, Ricardo Serrano, Christine Wahlquist, Alexander Kreymerman, Michelle M. Vu, Prashila Amatya, Charlotta Sophie Behrens, Sara Ranjbarvaziri, Renée G. C. Maas, Matthew Greenhaw, Daniel Bernstein, Joseph C. Wu, Donald M. Bers, Thomas Eschenhagen, Christian M. Metallo, Mark Mercola - Cell Reports 2020 cited by 405

channel SCN5A and dilated cardiomyopathy due to a mutation in the RNA splicing factor RBM20. The maturation media should increase the fidelity of hiPSC-CMs as disease models.