Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion

Authors: Elizabeth Murray, Shinelle Menezes, Jack C. Henry, J.L.D. Williams, Lorena Alba‐Castellón, Priththivika Baskaran, Ivan Quétier, Ami V. Desai, J. Marshall, Ian Rosewell, Marianthi Tatari, Vinothini Rajeeve, Faraz Khan, Jun Wang, Panoraia Kotantaki, Eleanor J. Tyler, Namrata Singh, Claire S. Reader, Edward Carter, Kairbaan Hodivala‐Dilke, Richard Grose, Hemant M. Kocher, Núria Gavara, Oliver M.T. Pearce, Pedro R. Cutillas, John F. Marshall, Angus J.M. Cameron - Cell Reports 2022 cited by 86

matrisome signature predicts poor outcome in pancreatic and other solid human cancers. Our data indicate that suppressing PSC myofibroblast function can limit important stromal tumor-suppressive mechanisms, while promoting a switch to a cancer-supporting CAF phenotype.