Alterations of human skin microbiome and expansion of antimicrobial resistance after systemic antibiotics

Authors: Jay‐Hyun Jo, Catriona P. Harkins, Nicole H. Schwardt, J. Portillo, NISC Comparative Sequencing Program, Matthew Zimmerman, Claire L. Carter, Md Amir Hossen, Cody J. Peer, Eric C. Polley, Véronique Dartois, William D. Figg, Niki M. Moutsopoulos, Julia A. Segre, Heidi H. Kong - Science Translational Medicine 2021 cited by 111

genes in all subjects who received doxycycline 100 mg or TMP/SMX, respectively. Last, analysis of metagenomic data revealed an increase of genes involved in gene mobilization, indicating stress responses of microbes to antibiotics. Collectively, these findings demonstrate direct, long-lasting effects of antibiotics on skin microbial communities, highlighting the skin microbiome as a site for the development and persistence of antibiotic resistance and the risks of overprescribing.